Petra Korpisalo

Uncovering ischemic microvascular pathology

[Petra Korpisalo @KorpisaloLab]

Excited to be able to start sharing results from our @SuomenAkatemia funded #IschemiaKinetics and #AngioParadox projects that aim to clarify the pathomechanistic role of the microvasculature in Critical Limb Threatening Ischemia. Follow to learn more!

[University of Eastern Finland @UniEastFinland]

Persistent over-dilation of muscle microvasculature may be one reason causing chronic limb-threatening ischemia, recent research from @KorpisaloLab shows. In the future, this surprising finding may offer new avenues for screening and treatment. https://t.co/kD0CptXVBv

[University of Eastern Finland @UniEastFinland]

Alaraajan hapenpuute voi johtua myös hiussuonten liiallisesta laajenemisesta, osoittavat viimeaikaiset tutkimustulokset KYSistä ja Itä-Suomen yliopistosta. Yllättävät tulokset voivat edistää potilaiden seulontaa ja hoitoa. @KorpisaloLab @Pshyvinvointi https://t.co/eta17ba74i

[Petra Korpisalo @KorpisaloLab]

@VaahtomeriLab What a perfect day of science, sun and discussions! Thank you Taija, Kari, Riikka, Pipsa, Sinem, Kati and everybody else at the Wihuri Research Institute for putting it all together!

[Petra Korpisalo @KorpisaloLab]

In just a week MSc Galina Wirth will defend her PhD thesis on microvascular dynamics of post-ischemic muscle regeneration. Highly skilled experimentation and careful analysis of data revealing novel physiological understanding of microvascular function. Amazing work 👏

[Petra Korpisalo @KorpisaloLab]

@ehj_ed @escardio @ESC_Journals More information about the role of the microvasculature in regulating post-ischemic muscle recovery and formation of chronic damage already available from my lab: https://t.co/1PvtCPQXmZ

Take a look for a better understanding of how the microvasculature affects muscle function.

[EHJ Editor-in-Chief @ehj_ed]

The role of anatomical and functional microvascular abnormalities in the ischaemic muscle of patients with chronic limb-threatening ischaemia!

#ischaemia #muscle #microvascular #cardiotwitter #EHJ @ESC_journals @escardio

https://t.co/ORBgJN9LSp

[Petra Korpisalo @KorpisaloLab]

@ehj_ed @ESC_Journals @escardio More information about the role of the microvasculature in regulating post-ischemic muscle recovery and formation of chronic damage already available also from https://t.co/1PvtCPQXmZ

[Petra Korpisalo @KorpisaloLab]

@ehj_ed @ESC_Journals @escardio Thank you Prof. Brian Annex and team from @UVABME for an editorial on our #EHJ paper https://t.co/9GbJ4SKCNN

We know the story is a bit complicated to grasp at once but we try to elaborate shortly!

[Petra Korpisalo @KorpisaloLab]

And, big thanks also to Prof. Brian Annex and his team from @UVABME for an editorial on our #EHJ paper

https://t.co/52vSEOlRtN

We know this is a bit complicated to grasp at once but we try to elaborate shortly 😊

#ischemia #ischaemia #clti #medical #microvasculature #escardio

[Petra Korpisalo @KorpisaloLab]

Also… Thank you so much @ehj_ed for acknowledging our work❤️

https://t.co/h24yABSskg

[Petra Korpisalo @KorpisaloLab]

Our data on microvascular pathology of ischemic human skeletal muscle out now in print. Take a look at the ❤️issue of the European Heart Journal dedicated to vascular biology and medicine -my favourites!

https://t.co/9GbJ4SKCNN

[EHJ Editor-in-Chief @ehj_ed]

EHJ issue 45 - 04 is out now:

Explore novel therapeutic targets for atherosclerosis, aortic dissection, peripheral artery disease, much more in this issue on vascular biology and medicine!

https://t.co/xiU6ZlrFO3

@escardio @ESC_Journals #EHJ #cardiotwitter

[Petra Korpisalo @KorpisaloLab]

@HaoYin20 @Cells_MDPI Thx for sharing 🙏

[Petra Korpisalo @KorpisaloLab]

@SsJankauskas @HaoYin20 Disease pathomechanisms are always complex. The poor prognosis of CLTI patients should tell us that we do not yet know enough and our findings open a whole new avenue to look at the disease and try to understand more.

[Petra Korpisalo @KorpisaloLab]

@HaoYin20 @SsJankauskas Interesting times ahead for CLTI/PAD 😉

[Petra Korpisalo @KorpisaloLab]

@HaoYin20 @SsJankauskas And the point is: resolving the arterial blockages may not revert the capillary phenotype back to normal if the arterialization has gone too far! This we suspect based on previous gene therapy studies.

[Petra Korpisalo @KorpisaloLab]

@HaoYin20 @CircRes @jmarpino @ajpheartcirc @iScience_CP Don’t know 🤷‍♀️ Maybe this closing of the arterialized vessels that you show in your image is the next step of the arterialization process we described?!?!?

[Petra Korpisalo @KorpisaloLab]

#MinäTutkin @SuomenAkatemia @Pshyvinvointi mikroverisuonten roolia kudoksen hapenpuutteen aiheuttajana valtimotukoksen jälkeen. Valtimotaudissa myös kudoksen mikroverisuonitus on vaurioitunut ja saattaa olla kykenemätön johtamaan happea kudoksiin vaikka verenkierto palautuisi.

[Petra Korpisalo @KorpisaloLab]

Looking for posters at #ESC23? Find a narrated tour through our findings at the #ESCCongress online resources https://t.co/jGvIrbABqi via @escardio and #ESC365.
@Pshyvinvointi @UniEastFinland @SuomenAkatemia @ESC_Journals @EVB_Org

[Petra Korpisalo @KorpisaloLab]

”Ischemia” is just one possible reason causing ”tissue hypoxia” after an arterial occlusion! Take a look at our latest publication in the #EHJ👇 to understand why it might be good to encourge the concept of ”acute and chronic hypoxia” in clinical medicine. @escardio #esc23

[EHJ Editor-in-Chief @ehj_ed]

Critical limb-threatening ischemia and microvascular transformation: clinical implications. Read more in #EHJ:
https://t.co/Vmhc1H0dtH

#CLTI #microcirculation #ESC2023 #cardiotwitter @escardio @ESC_Journals