Krezel Lab

In the Department of Chemical Biology (University of Wrocław) we study metal-dependent proteins and develop new fluorescent chemical tools.

[Krezel Lab @KrezelLab]

New Article in Communications Chemistry (Nature).
https://t.co/ljJpbu4Dns

[Krezel Lab @KrezelLab]

Over the next 4 years, thanks to @NCN_PL funding, we will explore "Principles of hidden zinc bioinorganic chemistry: Tuning sequence-structure-stability relationships for improved zinc protein functionality".  The PI of the project is @artur_krezel. #Opus #zinc

[Narodowe Centrum Nauki @NCN_PL]

❗️719 badaczek i badaczy otrzymało granty w konkursach #OPUS 27 i #PRELUDIUM 23, o łącznej wartości niemal 665 mln zł. W #OPUS padł rekord – przyznaliśmy finansowanie w wysokości 600 mln zł. To najwyższy budżet w historii tego konkursu. https://t.co/cVuw8WrPdp

[Krezel Lab @KrezelLab]

Biarsenical-based fluorescent labeling of metallothioneins as a method for ultrasensitive quantification of poly-Cys targets
https://t.co/AMwN0tW5Kz

[Krezel Lab @KrezelLab]

An efficient and easily obtainable butelase variant for chemoenzymatic ligation and modification of peptides and proteins
https://t.co/hi4x5xFGiN

[Krezel Lab @KrezelLab]

Site-Specific and Fluorescently Enhanced Installation of Post-Translational Protein Modifications via Bifunctional Biarsenical Linker | ACS Omega https://t.co/nHX3uAdqqx

[Krezel Lab @KrezelLab]

Antioxidant-related enzymes and peptides as biomarkers of metallic nan... https://t.co/aHCPtyCwYj

[Krezel Lab @KrezelLab]

Combining Native Mass Spectrometry and Proteomics to Differentiate and Map the Metalloform Landscape in Metallothioneins | Journal of Proteome Research https://t.co/hwtW6ydiKH

[Krezel Lab @KrezelLab]

Phytochelatins Bind Zn(II) with Micro- to Picomolar Affinities without the Formation of Binuclear Complexes, Exhibiting Zinc Buffering and Muffling Rather than Storing Functions | Inorganic Chemistry https://t.co/VwbsYDuFAt

[Krezel Lab @KrezelLab]

Calcium-assisted sortase A cleavage of SUMOylated metallothionein constructs leads to high-yield production of human MT3
https://t.co/NkUatbl1vg

[Krezel Lab @KrezelLab]

Structural Characterization of Cu(I)/Zn(II)-metallothionein-3 by Ion Mobility Mass Spectrometry and Top-Down Mass Spectrometry | Analytical Chemistry https://t.co/28mHJeON6E

[Krezel Lab @KrezelLab]

Differentiated Zn(II) binding affinities in animal, plant, and bacterial metallothioneins define their zinc buffering capacity at physiological pZn https://t.co/YOBlzS613V

[Krezel Lab @KrezelLab]

A combined biochemical and cellular approach reveals Zn2+-dependent hetero- and homodimeric CD4 and Lck assemblies in T cells: Structure https://t.co/sLiWQVvpz3

[Krezel Lab @KrezelLab]

A new article on mammalian zinc metallothioneins in Metallomics has just been published.
"The connection of α- and β-domains in mammalian metallothionein-2 differentiates Zn(II) binding affinities, affects folding, and determines zinc buffering properties"https://t.co/k9TfUdQwlz

[Krezel Lab @KrezelLab]

From methodological limitations to the function of metallothioneins – A guide to approaches for determining weak, moderate, and tight affinity zinc sites https://t.co/y4XbVqlUi3

[Krezel Lab @KrezelLab]

Ion mobility mass spectrometry and molecular dynamics simulations unravel the conformational stability of zinc metallothionein-2 species - now published in Chemical Communications https://t.co/SXBqyuVHQK

[Krezel Lab @KrezelLab]

OaAEP1 Ligase-Assisted Chemoenzymatic Synthesis of Full Cysteine-Rich Metal-Binding Cyanobacterial Metallothionein SmtA https://t.co/F8tpZqXPSK

[Krezel Lab @KrezelLab]

Our newest work on Zn(II)-dependent CD4 and Lck assemblies in T cells:
A combined biochemical and cellular approach reveals Zn2+-dependent hetero- and homodimeric CD4 and Lck assemblies in T cells https://t.co/w1taMB08ij

[Krezel Lab @KrezelLab]

We are happy to share our new study about synthesis of homogeneous site-specific Ub-peptide conjugates by a sortase mediated chemoenzymatic strategy, presented in @ACS_Omega by Singh et al. @Avi598 @artur_krezel
https://t.co/9eeQQ8vN1M