Over the next 4 years, thanks to @NCN_PL funding, we will explore "Principles of hidden zinc bioinorganic chemistry: Tuning sequence-structure-stability relationships for improved zinc protein functionality". The PI of the project is @artur_krezel. #Opus#zinc
❗️719 badaczek i badaczy otrzymało granty w konkursach #OPUS 27 i #PRELUDIUM 23, o łącznej wartości niemal 665 mln zł. W #OPUS padł rekord – przyznaliśmy finansowanie w wysokości 600 mln zł. To najwyższy budżet w historii tego konkursu. https://t.co/cVuw8WrPdp
Site-Specific and Fluorescently Enhanced Installation of Post-Translational Protein Modifications via Bifunctional Biarsenical Linker | ACS Omega https://t.co/nHX3uAdqqx
Combining Native Mass Spectrometry and Proteomics to Differentiate and Map the Metalloform Landscape in Metallothioneins | Journal of Proteome Research https://t.co/hwtW6ydiKH
Phytochelatins Bind Zn(II) with Micro- to Picomolar Affinities without the Formation of Binuclear Complexes, Exhibiting Zinc Buffering and Muffling Rather than Storing Functions | Inorganic Chemistry https://t.co/VwbsYDuFAt
Structural Characterization of Cu(I)/Zn(II)-metallothionein-3 by Ion Mobility Mass Spectrometry and Top-Down Mass Spectrometry | Analytical Chemistry https://t.co/28mHJeON6E
Differentiated Zn(II) binding affinities in animal, plant, and bacterial metallothioneins define their zinc buffering capacity at physiological pZn https://t.co/YOBlzS613V
A combined biochemical and cellular approach reveals Zn2+-dependent hetero- and homodimeric CD4 and Lck assemblies in T cells: Structure https://t.co/sLiWQVvpz3
A new article on mammalian zinc metallothioneins in Metallomics has just been published.
"The connection of α- and β-domains in mammalian metallothionein-2 differentiates Zn(II) binding affinities, affects folding, and determines zinc buffering properties"https://t.co/k9TfUdQwlz
From methodological limitations to the function of metallothioneins – A guide to approaches for determining weak, moderate, and tight affinity zinc sites https://t.co/y4XbVqlUi3
Ion mobility mass spectrometry and molecular dynamics simulations unravel the conformational stability of zinc metallothionein-2 species - now published in Chemical Communications https://t.co/SXBqyuVHQK
Our newest work on Zn(II)-dependent CD4 and Lck assemblies in T cells:
A combined biochemical and cellular approach reveals Zn2+-dependent hetero- and homodimeric CD4 and Lck assemblies in T cells https://t.co/w1taMB08ij
We are happy to share our new study about synthesis of homogeneous site-specific Ub-peptide conjugates by a sortase mediated chemoenzymatic strategy, presented in @ACS_Omega by Singh et al. @Avi598@artur_krezel
https://t.co/9eeQQ8vN1M