Krishnaswamy Lab

We develop data deep learning methods containing geometric, topological, dynamic systems-based constructs for discovery from scientific and biomedical data.

[Krishnaswamy Lab @KrishnaswamyLab]

Today, I’m proud to share our latest work published in @NatureBiotech describing MELD, a #MachineLearning algorithm for #SingleCell perturbation analysis.

Read this #tweetorial to learn about the work led by @dbburkhardt and Jay Stanley 🥳🎉🧪

https://t.co/yquu66G8No
(1/16)

[Krishnaswamy Lab @KrishnaswamyLab]

@dbhaskar92 @PKetonis @Pseudomanifold @mrguywolf @elizabethmunch @DrChrisPitt (14/n) I also want to share a link to the code on github. https://t.co/DSIhkEv5mG

[Krishnaswamy Lab @KrishnaswamyLab]

(1/15) Today, I'm proud to share Neurospectrum, a #DeepLearning framework for neural dynamics, out in Neurocomputing! Neurospectrum is a graph-based network that represents brain activity as graph wavelets and then uses an autoencoder to dimensionality-reduce this representation while preserving geometry and trajectories. The trajectories are then characterized by a series of geometric and topological descriptors for regression and classification tasks, including classification of OCD.

https://t.co/zrX5jPQa26

[Krishnaswamy Lab @KrishnaswamyLab]

(13/n) After the task, trajectories showed more frequent, localized sharp turns. This curvature increase was significantly greater in OCD than HC across both sexes, especially in males. Learned attention highlighted the Postcentral Gyrus and Putamen in females and the Superior Frontal Sulcus in males, consistent with regions previously implicated in OCD.

[Krishnaswamy Lab @KrishnaswamyLab]

Happy Halloween!!

[Steven Kleinstein 🖥 @skleinstein]

Interested to learn about Yale’s #PhD program in Computational Biology and Biomedical Informatics (CBB)? Join our virtual information session for interested applicants on Tuesday, November 10, 2026, 8–9PM ET.

👉Register at: https://t.co/h0jZii6Tj6

@YaleCBB
@YALEBBS

[Krishnaswamy Lab @KrishnaswamyLab]

@Pseudomanifold I met him once at Grizzly peak in Ann Arbor in 2007. He also conducted the band earlier that day at the football game!

[Krishnaswamy Lab @KrishnaswamyLab]

If you are headed to @NeurIPSConf then please consider submitting and abstract and attending co-located DREAM symposium featuring myself, @AlexanderTong7 @mariabrbic @mrguywolf @c_chaffer @locusJ @drAOPisco and others discussing AI in disease biology! Also get connected to the fantastic medical research in going on Sydney at @GarvanInstitute and the @AllClear_collab !