Kyle Walker

Dad | Husband | Rheumatologist | Internist |Trinity College Dublin School of Medicine Alumni | Opinions are my own and not medical advice.

[Janet Pope @Janetbirdope]

How to treat #RA-#ILD

Similar to #IPF
Occurs older men esp
Smoking risk
Vaccines
Etc

Philippe Dieude
#HOT #EULAR2026 @RheumNow

[CTV Ottawa @ctvottawa]

Carleton Place, Ont. restaurant named one of Canada’s top 100 dining spots in 2025 https://t.co/sboS5vmg52

[RMD Open @bmj_rmdopen]

🚨 New meta-analysis in RMD Open:
In pregnant women with antiphospholipid syndrome (APS), adding hydroxychloroquine (HCQ) to standard therapy was linked to:
✅ Higher live birth rates (OR 2.66)
✅ Lower obstetric complications (OR 0.19)
🍼 Well tolerated during pregnancy

🔗 https://t.co/8tT7qnrC98

#Rheumatology #APS #PregnancyJourney

[Paul Wischmeyer MD @Paul_Wischmeyer]

PPIs are one of most commonly (and often inappropriately) prescribed drug classes out there. This is a “Must Read” state-of-the-art review paper on PPIs, covering indications, harms & a guide for deprescribing 🆕 💊⚠️

🔗 https://t.co/lYyY8ymkcr
H/T @drkeithsiau

[Milena Bond @milena_bond]

As the #GCA landscape evolves, consistent terminology is essential for trials.
We developed a glossary of key signs/symptoms — a collaborative effort by an international task force.
📌 Part of the ACR/EULAR-supported #ResponseCriteria project.

🔗 https://t.co/otY2gcWEBH

[Dr. John Cush @RheumNow]

Secukinumab fails in GCA phase 3 RCT. Novartis announced top-line results from the GCAptAIN study evaluating secukinumab in adults with newly diagnosed or relapsing GCA. In a steroid taper RCT, the endpoint was sustained remission at Wk 52 compared to placebo https://t.co/OElPntjNNu

[Kyle Walker @KyleWalkerM]

@Janetbirdope @RheumNow Early “PMR” or early “ seroneg EORA” with prominent prox involvement… 🤔

[Alberto Giraldo @alb_giraldo]

#Autoimmune inner #ear disease (AIED) is a rare clinical entity (~ 1% of all cases of #hearing loss) characterized by a progressive fluctuating bilateral asymmetric sensorineural hearing loss that develops over several weeks to months. #Vestibular symptoms, #tinnitus and aural fullness are present in up to 50% of patients. AIED is defined as primary when the pathology is restricted to the ear. In up to a third of cases, AIED occurs in the context of a systemic autoimmune disease and is defined as secondary.

Due to the lack of specific diagnostic tests, both clinical suspicion and responsiveness to corticosteroids are the pillars for the diagnosis of autoimmune AIED. The evaluation of patients in whom this condition is suspected should include a detailed history and physical examination, an audiogram, an MRI and a limited laboratory workup to exclude secondary causes of hearing loss.

*From: Mijovic T, Zeitouni A, Colmegna I. Autoimmune sensorineural hearing loss: the otology-rheumatology interface. Rheumatology (Oxford). 2013;52(5):780-789.
🔗https://t.co/L2WlCUGgS7

#WorldHearingDay #WorldHearingDay2025

[ILLIASUL IBAD @IlliasulK]

Tweet 1:

🚀 The JAK-STAT Pathway – A Key Player in Cytokine Signaling!

Did you know that >40 receptors use this pathway? It’s critical for immune function, hematopoiesis, and inflammation!

Let’s break down JAKs, STATs, inhibitors & their clinical impact in a simple & engaging way! 🧵👇

#JAKSTAT #Immunology #Rheumatology #Sullysrounds #Trump #MedX #MedTwitter

[Janet Pope @Janetbirdope]

#Ultrasound for #GCA

Sensitivity 86%
Specificity 100%

Gold standard - expert #dx

if uncertain
👇
Protocol to send for #temporal #artery #biopsy

@CRASCRRheum #ASM25 poster tour

[Nouf Al hemmadi @NoufAhmedAlham2]

This is really interesting, every one mg increase in prednisone is associated with 3% increase risk of damage.

@RheumNow
#RNL2025

[Md Yuzaiful Md Yusof @Yuz6Yusof]

🚨Landmark trial: First anti-CD20ab, Obinutuzumab with +ve Phase 3 trial in #lupus nephritis is out 👏🙌🏻. OBI + MMF + GC was superior than Placebo + MMF + GC at WK76; complete renal response (uPCR<0.5, eGFR =>85% of baseline, no rescue); 46.4% vs 33.1%.

https://t.co/sflPccqQCs

[Rohit Aggarwal @docrota]

Pain is often ignored in myositis - comes from active disease, muscle damage & pain syndromes. Pain is common in myositis and associated with disease activity, so treating disease activity is imp. https://t.co/PexznSvy1E

[Dr. AK 🇮🇳 @docakx]

I can't share this enough.

[RMD Open @bmj_rmdopen]

🩺 Vascular inflammation persists in GCA patients despite prolonged treatment with GCs and TCZ

🔬 38.5% of patients still showed inflammation in repeated temporal artery biopsies after TCZ

🖼️ PET/CT and ultrasound also revealed ongoing activity

🔑 https://t.co/T9H2DyCVSH

[Healio Rheumatology @HealioRheum]

🤰 “Fertility in women with RA is nearly equal to the general population when treated according to a treat-to-target approach aimed at remission of disease"

More from Dr. Radboud Dolhain @ErasmusMC at #ACR24 ⬇️

https://t.co/t6x9grjo0M

[Janet Pope @Janetbirdope]

ACR take home

#PMR
Don’t 🛑 #TCZ at 6/12 or flare
#Sarilumab >#MTX
MTX loser in PMR #RCT
#Bari 👍in RCT

#GCA
#TCZ+MTX >TCZ in #aortitis
Rare for 1st Rx failure TCZ

WHO TO Rx w what?

ACR24 ACRBest @RheumNow @ACRheum
1698
1700
1697
0858
1696
0764

[Mrinalini Dey @DrMiniDey]

How long before starting MTX should pts receive PCV13 vaccine?
➡️In RA, PCV13 vaccine given 1 month before starting MTX led to significantly higher immunological response at 1 month compared to pts vaccinated on MTX
⏩Vaccinate pts before starting MTX

Ab2676 #ACR24 @RheumNow

[Mike Putman @EBRheum]

PHOENYCS GO, RCT of dapirplizumab, novel CD40Li in SLE

Met primary endpoint (NNT~6 for BICLA) & numerical improvements in many other endpts

1 MI & 1 death from infection over 213 pts

Encouraging for sure! Second phase 3 being launched

#ACR24 @RheumNow Abstr#L16 #ACRbest