LEVIRA'AH @LEVIYRE - Twitter Profile

LEVIYRE retweeted

@Rainmaker1973

5 days ago

A drug designed to help humans regrow teeth is advancing through development. The treatment focuses on a protein known as USAG-1 which functions as a natural brake on tooth formation. By inhibiting this protein researchers aim to activate the body's latent capacity to produce an extra set of teeth. Animal experiments have already demonstrated success with the method enabling mice to grow new teeth. The research has now progressed to human trials. A Phase I clinical study of the drug TRG035 was completed in Japan. It evaluated safety in 30 healthy adult male volunteers each missing at least one molar. It is essential to note that this initial trial has not yet confirmed the drug's ability to regenerate teeth in humans. It serves only as an early assessment of safety. The first intended recipients are not adults who have lost teeth due to decay gum disease injury or age. Instead researchers plan to begin with patients who have congenital tooth agenesis a condition in which individuals are born without several permanent teeth. Scientists propose that humans may possess a dormant third dentition or potential for a third generation of teeth beyond the primary and permanent sets. If this potential can be safely triggered tooth regrowth might eventually offer a viable alternative to dentures and implants. The developing company anticipates that clinical application could become feasible around 2030. This schedule however hinges on subsequent trials successfully demonstrating the growth of well positioned and fully functional teeth in human patients. At present the treatment is not a guaranteed solution. It nevertheless represents one of the most promising advances in the pursuit of genuine tooth regeneration. ["Stem Cell-based Therapeutic and Endogenous Regeneration Approaches for Congenital Tooth Agenesis." Stem Cell Reviews and Reports]

Rainmaker1973's tweet photo. A drug designed to help humans regrow teeth is advancing through development.

The treatment focuses on a protein known as USAG-1 which functions as a natural brake on tooth formation. By inhibiting this protein researchers aim to activate the body's latent capacity to produce an extra set of teeth.

Animal experiments have already demonstrated success with the method enabling mice to grow new teeth. The research has now progressed to human trials. A Phase I clinical study of the drug TRG035 was completed in Japan. It evaluated safety in 30 healthy adult male volunteers each missing at least one molar.

It is essential to note that this initial trial has not yet confirmed the drug's ability to regenerate teeth in humans. It serves only as an early assessment of safety.

The first intended recipients are not adults who have lost teeth due to decay gum disease injury or age. Instead researchers plan to begin with patients who have congenital tooth agenesis a condition in which individuals are born without several permanent teeth.

Scientists propose that humans may possess a dormant third dentition or potential for a third generation of teeth beyond the primary and permanent sets. If this potential can be safely triggered tooth regrowth might eventually offer a viable alternative to dentures and implants.

The developing company anticipates that clinical application could become feasible around 2030. This schedule however hinges on subsequent trials successfully demonstrating the growth of well positioned and fully functional teeth in human patients.

At present the treatment is not a guaranteed solution. It nevertheless represents one of the most promising advances in the pursuit of genuine tooth regeneration.

["Stem Cell-based Therapeutic and Endogenous Regeneration Approaches for Congenital Tooth Agenesis." Stem Cell Reviews and Reports]

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LEVIYRE retweeted

Anonymous

@YourAnonOne

6 days ago

For the first time, scientists have built a living cell from scratch, using only non-living chemicals. It feeds, grows, copies its own DNA, and splits into two, just like a real cell does. They named it SpudCell. It is fragile and simple, but it shows that the basic steps of life can be assembled by hand.

YourAnonOne's tweet photo. For the first time, scientists have built a living cell from scratch, using only non-living chemicals. It feeds, grows, copies its own DNA, and splits into two, just like a real cell does.

They named it SpudCell. It is fragile and simple, but it shows that the basic steps of life can be assembled by hand.

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LEVIYRE retweeted

Massimo

@Rainmaker1973

7 days ago

CERN has officially powered down the worlds largest particle collider. The Large Hadron Collider known as the LHC is a 17 mile or 27 kilometer underground ring near Geneva Switzerland. It accelerates particles to nearly the speed of light and collides them. In 2012 this facility enabled scientists to discover the Higgs boson. This particle relates to the field responsible for giving mass to other particles. The machine has now entered what CERN calls Long Shutdown 3. It is scheduled to resume operations around 2030 as the High Luminosity Large Hadron Collider. The primary aim of this upgrade is not to enlarge the collider significantly. Instead it focuses on improving the machines ability to generate high quality data. In particle physics luminosity measures the rate of particle collisions over time. Higher luminosity increases opportunities to detect rare phenomena that may point to new physics beyond current understanding. Currently the LHC detectors record about 60 proton proton collisions per bunch crossing. Following the upgrade this figure is expected to increase to between 140 and 200. Throughout its operational life the upgraded collider could generate approximately 380 million Higgs bosons. This represents a substantial rise from the roughly 55 million produced since the LHC began operations. A key objective involves detecting rare events where two Higgs bosons are created simultaneously. Such observations could provide deeper insights into the behavior of the Higgs field and offer information about conditions in the early universe following the Big Bang. The project includes replacing major detector components installing advanced timing systems and upgrading roughly 0.75 miles or 1.2 kilometers of magnets and other infrastructure within the LHC. CERN has confirmed that this work poses no risk of destroying the universe. Natural cosmic rays produce far more energetic collisions than those at the LHC. These rays have bombarded Earth and objects in space for billions of years without incident.

Rainmaker1973's tweet photo. CERN has officially powered down the worlds largest particle collider.

The Large Hadron Collider known as the LHC is a 17 mile or 27 kilometer underground ring near Geneva Switzerland. It accelerates particles to nearly the speed of light and collides them. In 2012 this facility enabled scientists to discover the Higgs boson. This particle relates to the field responsible for giving mass to other particles.

The machine has now entered what CERN calls Long Shutdown 3. It is scheduled to resume operations around 2030 as the High Luminosity Large Hadron Collider.

The primary aim of this upgrade is not to enlarge the collider significantly. Instead it focuses on improving the machines ability to generate high quality data.

In particle physics luminosity measures the rate of particle collisions over time. Higher luminosity increases opportunities to detect rare phenomena that may point to new physics beyond current understanding.

Currently the LHC detectors record about 60 proton proton collisions per bunch crossing. Following the upgrade this figure is expected to increase to between 140 and 200.

Throughout its operational life the upgraded collider could generate approximately 380 million Higgs bosons. This represents a substantial rise from the roughly 55 million produced since the LHC began operations.

A key objective involves detecting rare events where two Higgs bosons are created simultaneously. Such observations could provide deeper insights into the behavior of the Higgs field and offer information about conditions in the early universe following the Big Bang.

The project includes replacing major detector components installing advanced timing systems and upgrading roughly 0.75 miles or 1.2 kilometers of magnets and other infrastructure within the LHC.

CERN has confirmed that this work poses no risk of destroying the universe. Natural cosmic rays produce far more energetic collisions than those at the LHC. These rays have bombarded Earth and objects in space for billions of years without incident.

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LEVIYRE retweeted

Massimo

@Rainmaker1973

11 days ago

A small Canadian town has officially granted trees the status of living beings with legal rights. Terrasse-Vaudreuil, located roughly 40 miles (64 km) west of Montreal, unanimously passed a resolution on June 9 declaring that trees possess “the right to life, natural growth, integrity, and regeneration.” The town is among the first in Canada to endorse the Universal Declaration of the Rights of the Tree. Mayor Michel Bourdeau credited the initiative in part to filmmaker André Desrocher, whose work helped shift local perspectives on trees from mere scenery to vital living entities. “A tree is like a human being,” Bourdeau told CBC. “It breathes, it lives, it takes in water. It protects us from all sorts of things.” Facing repeated flooding in recent years, the municipality views trees as critical infrastructure. They cool urban areas, sequester carbon, purify air, support biodiversity, mitigate heat islands, and assist with stormwater management. The resolution calls for a review of local bylaws to strengthen tree protection and ensure proper replacement when removals occur. This step reflects the expanding global “rights of nature” movement, which seeks legal personhood for ecosystems, much like corporations already enjoy. A notable precedent in Quebec is the 2021 granting of legal personhood to the Magpie River by a regional government and the Innu Council of Ekuanitshit. Advocates believe such recognition could reshape development decisions, enhance climate resilience, and transform urban planning. In Terrasse-Vaudreuil, the message is clear: trees are not simply property, they are living systems essential to human communities.

Rainmaker1973's tweet photo. A small Canadian town has officially granted trees the status of living beings with legal rights.

Terrasse-Vaudreuil, located roughly 40 miles (64 km) west of Montreal, unanimously passed a resolution on June 9 declaring that trees possess “the right to life, natural growth, integrity, and regeneration.” The town is among the first in Canada to endorse the Universal Declaration of the Rights of the Tree.

Mayor Michel Bourdeau credited the initiative in part to filmmaker André Desrocher, whose work helped shift local perspectives on trees from mere scenery to vital living entities. “A tree is like a human being,” Bourdeau told CBC. “It breathes, it lives, it takes in water. It protects us from all sorts of things.”

Facing repeated flooding in recent years, the municipality views trees as critical infrastructure. They cool urban areas, sequester carbon, purify air, support biodiversity, mitigate heat islands, and assist with stormwater management.

The resolution calls for a review of local bylaws to strengthen tree protection and ensure proper replacement when removals occur.

This step reflects the expanding global “rights of nature” movement, which seeks legal personhood for ecosystems, much like corporations already enjoy. A notable precedent in Quebec is the 2021 granting of legal personhood to the Magpie River by a regional government and the Innu Council of Ekuanitshit.

Advocates believe such recognition could reshape development decisions, enhance climate resilience, and transform urban planning. In Terrasse-Vaudreuil, the message is clear: trees are not simply property, they are living systems essential to human communities.

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