Laboratory Investigation

THE SCIENCE THAT ADVANCES #PATHOLOGY. Official Journal of @TheUSCAP. Editor-In-Chief: Dr. David M. Berman, M.D., Ph.D. (@virchow)

[Laboratory Investigation @LIjournal]

From the LI Archives 🔬 | Revisiting the October 2026 cover of Laboratory Investigation, featuring digital pathology–based classification of tumor-associated stroma by EDB+FN IHC. #FromTheLIArchives #CoverSpotlight

🔗 Lewandowski et al. Read the article: https://t.co/YmrpISKCnG

[Laboratory Investigation @LIjournal]

New from Laboratory Investigation 🔬 | The MONKEY Challenge benchmarks deep learning for inflammatory cell detection in kidney transplant biopsies, supporting quantitative, AI-assisted Banff lesion assessment.

🔗 van Midden et al. Read the article: https://t.co/HhStqZHwi0

[Laboratory Investigation @LIjournal]

Popular from Laboratory Investigation 🔬 | Standardizing pathology-based assessment of mature tertiary lymphoid structures as a potential biomarker for immunotherapy response.

🔗 Vanhersecke et al. Read the article: https://t.co/kyfNsWEDXT

[Laboratory Investigation @LIjournal]

From the LI Archives 🔬 | Revisiting the September 2026 cover of Laboratory Investigation: tertiary lymphoid structure in thoracic NUT carcinoma highlighted by multiplex immunofluorescence. #LIArchives #CoverSpotlight

🔗 Wang et al. Read the article: https://t.co/5HOpYo9TyP

[Laboratory Investigation @LIjournal]

New from Laboratory Investigation 🔬 | Mutant p53 aggregation alters sialylated and sulfated glycan profiles and enhances Siglec-9 ligand availability in high-grade serous ovarian cancer.

🔗 Ikezaki et al. Read the article: https://t.co/5NSWk7soer

[Laboratory Investigation @LIjournal]

New from Laboratory Investigation 🔬 | Gastric cancers with a neuroendocrine carcinoma component show aggressive behavior, with ASCL1 and STAT3 linked to neuroendocrine differentiation and immune suppression.

🔗 Zhang et al. Read the article: https://t.co/2TQV5kreZC

[Laboratory Investigation @LIjournal]

New from Laboratory Investigation 🔬 | MAOA expression marks aged progenitor-like thymic epithelial cells and may help distinguish thymomas from thymic carcinomas.

🔗 Matsumoto et al. Read the article: https://t.co/mjmjYnenGe

[Laboratory Investigation @LIjournal]

New from Laboratory Investigation 🔬 | Stromal B7-H3 expression marks an immune-hot microenvironment and is associated with response to PD-1 blockade in gastric cancer.

🔗 Wang et al. Read the article: https://t.co/QH4l828tSG

[Laboratory Investigation @LIjournal]

New from Laboratory Investigation 🔬 | Sequential heat-induced epitope retrieval enhances antibody compatibility and signal detection for multiplex tissue imaging.

🔗 Delarue et al. Read the article: https://t.co/drNI0T2Rfe

[Laboratory Investigation @LIjournal]

Popular from Laboratory Investigation 🔬 | Exploring how digital pathology and AI are transforming diagnosis, biomarker assessment, and precision medicine.

🔗 Zhang et al. Read the article: https://t.co/PRySMmFLSr

[Laboratory Investigation @LIjournal]

Popular from Laboratory Investigation 🔬 | Digital pathology and AI are moving into routine pathology practice—from whole slide imaging and remote sign-out to AI-assisted diagnosis, prognosis, and treatment prediction.

🔗 Zhang et al. Read the article: https://t.co/eLkTfLTjco

[Laboratory Investigation @LIjournal]

Correspondence Spotlight 💬 | Exploring the added value of combining immunohistochemistry and dual-probe chromogen in situ hybridization for improved HER2 status evaluation.

🔗 Angerilli et al. Read the article: https://t.co/leVZSNlyhh

[Laboratory Investigation @LIjournal]

New from Laboratory Investigation 🔬 | Knowledge-guided multimodal AI integrates pathology and clinical data to predict treatment response and survival in breast cancer.

🔗 Zhang et al. Read the article: https://t.co/woyuxNT0zu

[Laboratory Investigation @LIjournal]

New from Laboratory Investigation 🔬 | A needle-based sampling strategy enables spatially traceable fresh-frozen tissue collection from radical prostatectomy specimens while preserving routine pathologic assessment.

🔗 Ishibashi et al. Read the article: https://t.co/XG5BBy79OZ

[Laboratory Investigation @LIjournal]

Research Article Spotlight 🔬 | Advancing tumor microenvironment analysis with automated, whole-slide 14-color multiplex immunofluorescence staining in paraffin-embedded tissue.

🔗 Lai et al. Read the article: https://t.co/9W41xkOdwz

[Laboratory Investigation @LIjournal]

Research Article Spotlight 🔬 | Investigating KLK10 upregulation and its association with aggressiveness, radioresistance, and prognosis in rectal cancer.

🔗 Chou et al. Read the article: https://t.co/iYmhHUpg4n

[Laboratory Investigation @LIjournal]

Research Article Spotlight 🔬 | Exploring the diagnostic utility of POU2F3 in neuroendocrine-low/negative small cell lung cancer and its distinction from other thoracic malignancies.

🔗 Chen et al. Read the article: https://t.co/F6kl5ki4AB

[Laboratory Investigation @LIjournal]

Research Article Spotlight 🔬 | Examining progressive YAP1 activation across HPV-associated squamous intraepithelial lesions and squamous cell carcinoma.

🔗 Zhang & Yang. Read the article: https://t.co/qZvg8O04gq

[Laboratory Investigation @LIjournal]

Research Article Spotlight 🔬 | Evaluating artificial intelligence as a stand-alone tool for cervical cancer screening using a 50% negative cutoff.

🔗 Dong et al. Read the article: https://t.co/mrQ1Nu4PU2

[Laboratory Investigation @LIjournal]

Research Article Spotlight 🔬 | Investigating how ARHGEF26 maintains SOX2 stability to promote glioblastoma stemness.

🔗 Chen et al. Read the article: https://t.co/2CdtCcD87q