Grosshans Lab

Studying mechanisms of developmental clocks and timers

[Grosshans Lab @LabGrosshans]

Out now – our paper using temporally highly-resolved expression profiling and mathematical modeling to detect dynamic #miRNA expression in #C. elegans larvae and determine the mechanisms: https://t.co/aUO9MoBibw @FMIScience 1/8

[Grosshans Lab @LabGrosshans]

Time to X-it. Find us now on Bluesky: https://t.co/OiYTW76KJM

[Grosshans Lab @LabGrosshans]

Born out of a project on RNA silencing and thus funded, in part, by the @NCCR_RNADisease - thank you 🙏!

[Grosshans Lab @LabGrosshans]

Now out in @MolSystBiol 👇 - predicting protease activity quantitatively from a one-shot experiment as a way to engineer substrate half-lives and characterize proteases. Tweetorial (from the preprint) here: https://t.co/OqSPKk9tw8

[Mol Syst Biol @MolSystBiol]

@LabGrosshans develop a quantitative model for protease cleavage specificity and cooperativity of protease sites ➡️ https://t.co/QeT8SEzkCy

[Grosshans Lab @LabGrosshans]

Join us in our Proteomics Platform. And if you'd like a peek at some of the fun stuff we are doing, take a look at our latest paper, combining proteomics and modelling to assess and predict quantitatively protease substrate specificity https://t.co/u1XgTu7KMV (more details later)

[FMI science @FMIscience]

The Proteomics Platform at the FMI is seeking a skilled Proteomics Specialist who is passionate about cutting-edge technologies in multi-disciplinary projects.
Apply by November 30, 2024 at https://t.co/OvBnCN4V31

[Grosshans Lab @LabGrosshans]

Very cool 👇

[Tsiairis Lab @TsiairisLab]

🔬✨ New insights into tissue regeneration! Our study uncovers a novel mechanochemical mechanism in Hydra, revealing how mechanical forces and Wnt signaling work together to create intricate tissue patterns. #Cnidarians #Hydra #Biology #Regeneration https://t.co/3Dk6IFFGsj

[Margarete Diaz Cuadros @MDiazCuadros]

We are recruiting a postdoctoral fellow @DiazCuadrosLab! Please spread the word! Check out our lab website for more information: https://t.co/ZtGvGsJquM

[Luisa Cochella @LCochella]

Deadlines are approaching for @KeystoneSymp #NonCodingRNA Biology: New Roles and Diversity, this January in Keystone! See scholarship, abstract and discount reg dates: https://t.co/nSQjFRWXkv #KSncRNA25

[Alper Akay @alperakay_]

We have a 4-year PhD position in our lab to study RNA splicing regulation in collaboration with @YiliangDing @biouea @alperakaylab @NorwichRNAClub #RNA #Celegans #PhDposition https://t.co/sioYGEoKWR

[Grosshans Lab @LabGrosshans]

Always a pleasure when alumni visit the lab, bringing back lots of fond memories. Thanks also for sharing the latest insights into miRNA decay, @mdlmata !

[NCCR RNA & Disease @NCCR_RNADisease]

Register now & submit abstracts (deadline Dec 8) for the #Swiss #RNA Workshop on January 24, 2025, starting at 09:15 @unibern.
Short talks selected from abstracts. Registration free of charge. See the next tweet for sponsors. https://t.co/066l8WgQMr
Please help spread the word!

[Harvard Medical School @harvardmed]

Nobel Laureate and HMS Professor Gary Ruvkun shared lighthearted tales about his start, a science revolution, and the power of worms.

[Grosshans Lab @LabGrosshans]

Super exciting opportunity in the lab of our new colleague Anupama - do apply 👇

[Anupama Hemalatha @AnuHemalatha]

Looking forward to hiring my first PhD student this cycle🤩. If you are interested in using live imaging to understand how metabolic states are integrated with cell behaviors and fates, please apply! DM me for more info.

[NCCR RNA & Disease @NCCR_RNADisease]

News Report of Swiss National Radio (@srfnews) on the #miRNA #NobelPrize featuring NCCR PIs Helge Grosshans (@LabGrosshans, @FMIscience) and Markus Stoffel (@ETH_DBIOL, @ETH_en):
https://t.co/7l1M5pRoPY

[Grosshans Lab @LabGrosshans]

Could not agree more - without "bluesky" fundamental research, no translational research, no clinical/medical application.

[Guillaume Diss @Guillaume_Diss]

We’re looking for a postdoc with a strong background in AI, biophysics, modeling or related.

Please forward to potential candidates and RT 🙏

More details below 👇

[Grosshans Lab @LabGrosshans]

@irmdirector Seems the pressure is on you then to make it three 😂 - congratulations on your share in co-discovering the let-7 miRNA and establishing its function!

[Grosshans Lab @LabGrosshans]

@Abhi_Biotech And the neighborhood got even better now that we are in our new home on the beautiful Novartis campus 😃 - and just a short bike ride from the Biozentrum.

[Grosshans Lab @LabGrosshans]

Because developmental processes are no longer properly timed across tissues, the vulva is no longer properly attached in the mutant worms - with dramatic consequences.

[Grosshans Lab @LabGrosshans]

We will be hiring 👇 - apply if you are interested in understanding mechanisms of developmental timing using genomics, genetics, molecular biology, quantitative time lapse imaging, modelling, ...

[FMI science @FMIscience]

Still a few week left to apply to our PhD and MD-PhD programs! Join us if you want to do cutting-edge research in the life sciences while enjoying a vibrant, international and supportive environment 👇🏽

[Grosshans Lab @LabGrosshans]

How timely - https://t.co/bZ6JE5FrXU: Ambros and Ruvkun discovered miRNAs by studying the developmental timing pathway on which this PhD project focuses - the video 👇shows the consequences of mutating the let-7 miRNA, https://t.co/Sg2nRoBTE3

[Chiara Azzi @azziChiA]

It couldn’t be a better day to apply for a PhD in the @LabGrosshans! Amazing environment and great mentor!