Sakai Disc Lab

Dai Sakai's research team specialized in #regenmed therapies for IVD repair and deformity corrections. Maintained by @iDeJordy

[Sakai Disc Lab @LabSakai]

It was time for a #groupphoto update. So #inspired and #motivated by all these fantastic and hardworking researchers.

Also great to see @LabSakai is becoming more and more international. Expect more great things to come your way very soon. 😉

[Sakai Disc Lab @LabSakai]

It is truly inspiring to witness the collaborative efforts between our societies and the incredible reach we achieve as scientists through these partnerships.

[ISSLS @ISSLS_Society]

Calling all @OrsSpineSection Members! 

🤝 To our friends @OrsSpineSection:
We’d love to see you at #ISSLS2025 in Atlanta!
🔹 Collaborate with the global spine community
🔹 Present your groundbreaking work
🔹 Propose exciting joint symposia

Let’s strengthen our partnership!

[ISSLS @ISSLS_Society]

Calling all @OrsSpineSection Members! 

🤝 To our friends @OrsSpineSection:
We’d love to see you at #ISSLS2025 in Atlanta!
🔹 Collaborate with the global spine community
🔹 Present your groundbreaking work
🔹 Propose exciting joint symposia

Let’s strengthen our partnership!

[Sakai Disc Lab @LabSakai]

New study in @JORSpine exploring #HybridSurgery combining cervical disc #arthroplasty and ACDF offered biomechanical benefits in revision surgery, especially with D-C-D models. Great insights for hybrid surgical strategies! @OrsSpineSection

Read it here: https://t.co/PDzECTQAgh

[Sakai Disc Lab @LabSakai]

New @JORSpine work on "Spine Tester TO GO"!
This innovative tool enables both biomechanical & biological tests on the same specimen, reducing the need for animals & supporting the 3R principle. 🐭🐷🐶

Find work here: 🔗https://t.co/WrTrpI1bib

@OrsSpineSection @ORSPCMSection

[ORS Spine Section @OrsSpineSection]

Looking forward to seeing everyone this Wednesday at our annual social hour! Registration link below!

[Sakai Disc Lab @LabSakai]

New @JorSpine study identifies IVDD #biomarkers. 🔬 Using advanced #bioinformatics, researchers found 10 hub genes, with #JUNB, #SOCS3, and #CEBPB emerging as top candidates. New diagnosis and therapeutic targets? 🧠💡

🔗 Read more: https://t.co/Dzo9Lh7HLD

@OrsSpineSection

[ISSLS @ISSLS_Society]

A reminder that registration and abstract submission are now open for #ISSLS2025

Categories include:
👉 Non-Surgery
👉 Surgery
👉 Biomechanics, muscle, and motor control
👉 Basic Science
👉 Imaging
👉 Epidemiology

🔗 https://t.co/zkM3RiJhzz

#SpineResearch #LumbarSpine

[Arnold Wong @arnoldwongPT]

Honored to be involved in this NIH-funded study uncovering a link between gut microbiome dysbiosis and lumbar degenerative spondylolisthesis (LDS). Higher pro-inflammatory bacteria in LDS patients may drive spine degeneration. Exciting new insights! 🧠🔬 @ISSLS_Society @NASSspine

[Sakai Disc Lab @LabSakai]

New @JORSpine study suggests a link between gut microbiome dysbiosis & lumbar degenerative spondylolisthesis! Patients with LDS showed distinct gut bacterial patterns, including more pro-inflammatory taxa. Could gut health be key to spine care? 🤔

🔗https://t.co/0xLV5U0LEQ

[Sakai Disc Lab @LabSakai]

📝 New study in @JorSpine underlines link IDD and Tnf-α/Tnfr signaling pathway.

Tnfr1/2 #knockout mice showed #TNFR deficiency alleviates age-related and spine instability-induced IDD by enhancing ECM metabolism.

See: https://t.co/QhIqqcrRt2

@OrsSpineSection @ORSPCMSection

[ISSLS @ISSLS_Society]

🚨 Exciting News! 🚨

The #ISSLS2025 registration & abstract submission is now open!

This year’s meeting will be held in Atlanta, GA, from May 12-16, 2025 at the Westin Buckhead hotel. 🏙️

[Sakai Disc Lab @LabSakai]

New in @JORSpine: A dual-model #AI system for #LDH patients automates muscle segmentation and fatty infiltration (FI) annotation on #MRI, showing shows high accuracy in paraspinal muscle and FI assessment compared to traditional methods!

🔗https://t.co/5GITEsjBwz

[Sakai Disc Lab @LabSakai]

🔧 New study @JORSpine: A #DeepLearning model accurately identifies pedicle screw brands from spine radiographs, aiding preoperative planning in revision #spinesurgery. The AP+Lateral ensemble model achieved 94% accuracy, matching experienced surgeons!
🔗https://t.co/jzguaoOQcb

[Sakai Disc Lab @LabSakai]

New @JORSpine:
A new U-Net model automates 3D disc segmentation from spine MRIs, matching manual accuracy and streamlining analysis across diverse ages and degeneration levels.
#AI #MRI #MedicalImaging @OrsSpineSection
https://t.co/P2xFYm73G7

[Sakai Disc Lab @LabSakai]

New @JORSpine review on #Curcumin's potential to mitigate spinal cord injury complications by modulating key inflammatory pathways like #Nrf2, #NFkB, and #TGFβ. 🌿 Could curcumin be the future of SCI treatment?

Find out more: https://t.co/TEk0aFEAnq

[Sakai Disc Lab @LabSakai]

New @JORSpine review examines discogenic #backpain and explores how biomolecular therapies could target pain pathways beyond IVD degeneration showing the need for therapies addressing chronic LBP. Learn more: https://t.co/9OXCKz02N6

@OrsSpineSection
#SpineHealth #BioMolecular

[ISSLS @ISSLS_Society]

Applications are open to join @ISSLS_Society! Be part of a global network of spine research leaders advancing #LumbarSpine care. 🌍

Deadline: September 1st❗️

Learn more about all the benefits and how to apply:
🔗https://t.co/WXFNJl7GxQ

#SpineResearch #JoinISSLS #RetweetMe

[Sakai Disc Lab @LabSakai]

Study in @JORSpine reveals how ligamentum flavum degeneration contributes to spinal stenosis; key changes in tissue structure, composition, and biomechanics. 🧬
Learn more: https://t.co/J3BF4031wV #SpineHealth #Orthopedics

[Sakai Disc Lab @LabSakai]

📄 Read the paper: https://t.co/TEsVroAiVP #RegenerativeMedicine #SpineResearch #CellTherapy #RegenMed #BackPain
@OrsSpineSection @ISSLS_Society

[Sakai Disc Lab @LabSakai]

New @LabSakai study alert! 🚨

Our latest research in @IJMS_MDPI reveals key insights into the regenerative potential of Tie2+ NP progenitor cells (NPPCs) from young vs. older donors.

[Sakai Disc Lab @LabSakai]

Despite similar #Tie2 positivity rates, older NPPCs showed significant differences in #GD2 positivity and proliferation. Highlighting the need to consider age in cell-based therapies. Dive into the full study for more on optimizing methods and implications for IVD #regeneration!