Schellenberg Lab

DNA repair lab at the Mayo Clinic

[PhRMA Foundation @PhRMAfoundation]

#PhF25 predoc awardee Anh Cong @MayoGradSchool is researching how to protect the heart during #chemotherapy. She's studying the proteins targeted by anthracyclines, which are effective against #cancer but can cause heart issues.

Watch the full interview: https://t.co/DOAfxB5m7o

[Schellenberg Lab @LabSchellenberg]

This was an awesome collaborative team effort by scientists from @MayoClinic @mayoclinicbmb @MayoGradSchool @MayoCancerCare @newcastleuni and the faculties of Pharmacy and Medicine at Charles University.

[Schellenberg Lab @LabSchellenberg]

Topobexin is an inhibitor that targets Topoisomerase IIβ's ATPase domain—protecting the heart from anthracycline chemo damage without reducing anticancer power. Read our article about this potentially game-changer in cardio-oncology @natcomms.nature.com https://t.co/Iy9LYen8pB.

[Matthew Goetz @mpgoetz]

Endoxifen is known to be a more potent inhibitor of ER alpha compared to tamoxifen.  Based on an unbiased proteomic screen, we identify protein kinase beta as a new endoxifen drug target, resulting in suppression of AKT signaling and apoptosis

https://t.co/AUP5TWQnat

[Dr. Amanda Riccio @AmandaRiccioPhD]

We are so excited to present “Structural insight and characterization of human Twinkle helicase in mitochondrial disease” in @PNASNews https://t.co/NONARu3nHT

[Dr. Amanda Riccio @AmandaRiccioPhD]

Alpha fold definitely has its uses, it’s great starting model, but then there’s oligomerization, conformational change, protein-to-protein interactions. We aren’t out of a job! #structuralbiology

[Schellenberg Lab @LabSchellenberg]

@science_SRH https://t.co/4GzvgLvzz0

[Schellenberg Lab @LabSchellenberg]

@science_SRH Yfp-tag and TEV

[Schellenberg Lab @LabSchellenberg]

@science_SRH Papers with methods:

https://t.co/WSD5LKOebp

[Schellenberg Lab @LabSchellenberg]

Today is my first in-person conference talk as a PI! It’s been a great PS36 meeting in San Francisco

[Schellenberg Lab @LabSchellenberg]

@vballjulia @MayoClinic Welcome to Rochester!

[GERG @GregDodge9]

One of my fav lab hacks: store your E coli pellets in freezer bags. They freeze in 5 mins, resuspend in under 3 mins (in the bag!), take up less freezer space, and don't waste conical tubes!

[Schellenberg Lab @LabSchellenberg]

@mjborgnia @CryoJB Wow, that looks awesome!! Great work.

[Schellenberg Lab @LabSchellenberg]

Congratulations to our Mayo graduate student Sowmiya Palani and her poster prize at the in-person @Fusion_Conf #DRRSC22

[Schellenberg Lab @LabSchellenberg]

@ck_vilas @genentech Congratulations! That’s awesome!

[Schellenberg Lab @LabSchellenberg]

@HoorayForZinder It’s the best! It’s amazing how satisfying it is to be able to actually see the protein we work with.

[Lucrezia Catapano @lulu_catapano]

Old coot vs new coot! 😃

[Schellenberg Lab @LabSchellenberg]

@jdoles99 Wow! Well done. That should go on their CV

[Schellenberg Lab @LabSchellenberg]

@MachidaLab @MayoClinic @NCIResearchCtr @theNCI You will indeed be missed!

[Schellenberg Lab @LabSchellenberg]

@TRyanGregory So much to unpack in here.