Tinnefeld Lab

Our NanoBioSciences lab @LMU_Muenchen brings together a unique combination of #molecularbiology, #physicalchemistry, #biophysics and #nanophotonics.

[Tinnefeld Lab @LabTinnefeld]

5/5 Congratulations to the authors🥳 @MartinaPfeiff , Fiona Cole, Dongfang Wang, @YonggangKe and @PhilipTinnefeld

[Tinnefeld Lab @LabTinnefeld]

1/5🚀🔬 New paper alert!
We built a spring-loaded DNA origami nanorobot that can sense, compute, and act — basically, a molecular PC made of DNA 🧬💻
#DNAorigami #nanotech #robotics #moleculardesign #SciRobotics
https://t.co/Ie8VQpcxam

[Tinnefeld Lab @LabTinnefeld]

4/5 How? SEPP is a spring-loaded network of DNA “antijunctions” that flip between states, like tiny molecular switches. We can program them with DNA strands to make logic gates, timed actions, and even cargo release. Basically, tiny robots doing science at 1 billionth the size🤏

[Tinnefeld Lab @LabTinnefeld]

4/4 Huge shout-out to the amazing team🥳:  @TSchroder_ , Julian Bauer, @pa_schueler , @J_Zaehringer , Fiona Cole, @GioFerrari__, Laura Barnard, Karen Gronbach, @GBruggenthies , @PhilipTinnefeld

[Tinnefeld Lab @LabTinnefeld]

1/4 📢🥳now online: BROWNIAN DNA COMPUTING - Unlike fuel-driven molecular computing with high-energy barriers, it exploits thermal fluctuations.
Inputs rectify state access, enabling fast, low-energy computation. 📜More in our preprint: https://t.co/pMUaorDbdn

[Tinnefeld Lab @LabTinnefeld]

3/4 MPUs are fully modular🖥️. We built:
 ✔ All basic Boolean logic gates
 ✔ Multi-input compact gates
 ✔ A half adder
✔ Even non-Boolean logic

[Tinnefeld Lab @LabTinnefeld]

3/3 Congratulations to all the authors for the team work🥳: @renukka_y, @k_trofymchuk, @MihirDass , Benedkit Hauer, Vivien Behrendt, Jan Schütz, Cindy Close, Michael Scheckenbach, @GioFerrari__, Leoni Mäurer, Sophia Sebina, @glembockyte, Tim Liedl and @PhilipTinnefeld

[Tinnefeld Lab @LabTinnefeld]

1/3 🚨🥳New paper out in Advanced Materials!
We bring attomolar, amplification-free DNA detection to the point-of-care using DNA origami nanoantennas.🧬Check it out here: https://t.co/owGOLsKHB3

[Tinnefeld Lab @LabTinnefeld]

2/3 We made a short video📽️that provides a quick summary of the topic.

[Universität München @LMU_Muenchen]

🎉 Großer Erfolg in der Exzellenzstrategie für die #LMU: Alle sieben beantragten Exzellenzcluster haben sich im Begutachtungsverfahren durchgesetzt und werden ab 2026 für sieben Jahre gefördert! Ein herausragendes Ergebnis! 🎉https://t.co/06mVsPbWtl

[Nature Methods @naturemethods]

And read the News & Views from @PallavKosuri on this work, here:

https://t.co/FixrBsQuai

[Tinnefeld Lab @LabTinnefeld]

Awardees of Römer Prize 2024 presenting their theses: Jakob (Master), Martina (PhD) and @lgrabenhorst_ (PhD). Congrats to all of you!🥳👏 https://t.co/gi522eJN4J

[Viktorija Glembockyte @glembockyte]

Excited to share it now in its final form in @NatureNano: our approach to decouple sensing from signal output to build modular and tunable DNA origami sensors with high FRET contrast: https://t.co/ycqfsfpSiN 💡🧬🔬

[Tinnefeld Lab @LabTinnefeld]

4/5 Huge congrats to the whole team! Big thanks to @SzalaiAlan, @GioFerrari__, @LarsRichterr for leading this work, and to everyone involved: @AndrsMVera1, @IzabelaKamm, @aksimentievLab , @KushCoshic, Ingrid Tessmer, @PhilipTinnefeld . Exciting GETvNA applications on the way!

[Tinnefeld Lab @LabTinnefeld]

1/5 DNA and DNA/protein conformations at Ångström/millisecond resolution—right in a fluorescence microscope! Check out our new GETvNA paper in @naturemethods :
https://t.co/vBCMkZNcJb
Want to learn about the science behind GETvNA?

[Tinnefeld Lab @LabTinnefeld]

4/5 We also applied GETvNA to track the diffusion of AGT along DNA, being able to detect distinctive diffusional modes and preferential binding to A-tracts, while reaching single-base pair resolution.