Tiwari Lab

Deciphering epigenetic mechanisms and transcription factors that wire gene expression programs

[Tiwari Lab @LabTiwari]

Junior #CancerSymposium 2025
Hosted by the Translational Cancer Hub at #SDU University
We were thrilled to welcome bright young minds to the Junior Cancer Symposium — a day filled with inspiring talks, innovative research...

Read more: https://t.co/vNpWBN8aZS
#TiwariLab

[Tiwari Lab @LabTiwari]

Brain metastases (BrMs) present a major challenge in cancer treatment, with limited molecular profiling to date. This study applies integrative single-cell RNA sequencing to 108 BrMs and 111 primary tumors across...
Read more: https://t.co/UlSI37BGGO
#TiwariLab #JournalClub

[Tiwari Lab @LabTiwari]

This study presents a groundbreaking exploration into the complexities of gene regulation. Utilizing the innovative CAP-SELEX technique, researchers mapped over 58,000 transcription factor (TF) pairs, uncovering...

Read more: https://t.co/oKjYkO45CV

#TiwariLab #JournalClub

[Tiwari Lab @LabTiwari]

In this study, the authors introduced a novel method—multi-omics single-cell optimal transport (Moscot). Compared to traditional optimal transport (OT) approaches, moscot offers three key technical advancements: multi...

Read more: https://t.co/XtCw8wnM9k
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[Tiwari Lab @LabTiwari]

The immune checkpoint blockade (ICB) therapies have shifted the treatment paradigm for non-small-cell lung cancer (NSCLC), many patients remain resistant.
In this study, the authors integrate scRNA-seq (>200K cells)...

Read more: https://t.co/CqzxJoTQfP
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[Tiwari Lab @LabTiwari]

This paper introduces DEPLOY, a deep learning model designed to enhance the diagnosis of central nervous system (CNS) tumors. Accurate diagnosis of CNS tumors is critical for effective treatment...

Read more: https://t.co/gM6qMUREzQ
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[Tiwari Lab @LabTiwari]

In this study, the authors found that Rela/NF-κB activation reprogrammed microglia into a pro-inflammatory phenotype, which enhanced antitumor immunity and reduced MBM burden.

Read more: https://t.co/I7zVPUEAOa
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[Tiwari Lab @LabTiwari]

This interesting article presents a novel approach by using CRISPR-Cas9 to knock out over 20,000 genes across human cell lines, creating a genome-wide map of how gene perturbations influence cell morphology.

Read More: https://t.co/5nOZWg3E2Y
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[Tiwari Lab @LabTiwari]

#SDU and #OUH Celebrate the Launch of the Center for Integrated Multi-Omics in Precision Medicine (#CIMP).

Read more:
https://t.co/vIdxTNa7Ud
#TiwariLab

[Tiwari Lab @LabTiwari]

This study functionally validated cross-disorder GWAS loci, identifying regulatory variants (emVars) and their target genes using eQTLs and chromatin architecture.

Read more: https://t.co/gdHCPKoszS
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[JCI insight @JCI_insight]

ICYMI: By using SEEG electrodes from epilepsy patients to gather RNA, DNA & protein data, @LabTiwari @SyddanskUni reveals unique molecular profiles tied to brain activity--potentially improving epilepsy diagnosis and treatment... https://t.co/BC6Wx4N1ZD

[Tiwari Lab @LabTiwari]

This study provides a comprehensive multi-omic atlas of the developing human neocortex, spanning five developmental stages from the first trimester to adolescence.
Read more: https://t.co/6aaddwhtkp
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[Tiwari Lab @LabTiwari]

Souren works on uncovering the molecular mechanisms of a gene marker that seems to be associated with Autism Spectrum Disorder.

Youtube link: https://t.co/2Hqec0Hdcg

Read more: https://t.co/nd8ah0Xo97
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[Tiwari Lab @LabTiwari]

An interesting study that introduces the General Expression Transformer (GET), an advanced foundation model designed to unravel transcriptional regulation mechanisms across diverse human cell types.

Read more: https://t.co/KV8t001PA8
#TiwariLab #JournalClub

[JCI insight @JCI_insight]

By using SEEG electrodes from epilepsy patients to gather RNA, DNA & protein data, @LabTiwari @SyddanskUni reveals unique molecular profiles tied to brain activity--potentially improving epilepsy diagnosis and treatment... https://t.co/BC6Wx4NzPb

[Tiwari Lab @LabTiwari]

This study introduces a comprehensive human neural organoid cell atlas created from 1.7 million cells across 36 single-cell transcriptomic datasets and 26 protocols.

Read more: https://t.co/xFz4VNFcsA

#TiwariLab #JournalClub

[Tiwari Lab @LabTiwari]

A groundbreaking study from our lab "Pan-cancer drivers of metastasis", led by our PhD student Ryan Lusby, reveals critical insights into the mechanisms driving cancer metastasis-the leading cause of cancer-related deaths.

Read more: https://t.co/QAgrPGofxQ
#TiwariLab

[Tiwari Lab @LabTiwari]

In this study, researchers employed spatial transcriptomics to investigate the tumor architecture and microenvironment of triple-negative breast cancer (TNBC) in 92 patients.
Read more: https://t.co/i5hdaxStf6
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[Tiwari Lab @LabTiwari]

Morteza aims to predict the single-cell transcriptome from H&E staining only. He develops an AI method to gain insights into the putative molecular pathways active in the cancer of interest...

Read More: https://t.co/Mtiyrhvs2H

@SyddanskUni
#SDU #TiwariLab

[Tiwari Lab @LabTiwari]

Excited to share our latest publication on advancing epilepsy research with multimodal profiling of living brain tissue! Check it out here: https://t.co/4tZ6kZgRsv #EpilepsyResearch #Neuroscience #TiwariLab @80Anuj @SyddanskUni