Lander Lab

[Lander Lab @LanderLab]

Last chance to apply to the Cold Spring Harbor #cryoem course this March (application deadline is Jan 15th)! Learn all about sample prep, microscope operation, and image processing at this fun 2-week course @kollmanlab @Jen_Cash_11 @cshlcourses https://t.co/iZ2eOD2vVs

[Lander Lab @LanderLab]

Congrats to our grad students who pitched therapeutic targets at this year's @ScrippsGradPrgm Drug Discovery Shark Tank - particularly Shelby @ShelbyFerrier and Morgan @m_m_gee on their winning proposal to target Cholera toxin subunit B, which raised $4 million!

[Hurley Lab @TheHurleyLab]

Proud of new work https://t.co/VVD4eyFOlc from the lab by Zhicheng (Chen) Cui @Chen3dem using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/ @G__Napolitano, A. Esposito, and A. Ballabio.

[Lander Lab @LanderLab]

You can now follow us at https://t.co/Ie09FzqH71

[Lander Lab @LanderLab]

The human mitochondrial ClpXP is uniquely assembled and regulated compared to its bacterial counterparts. Congrats to Kelly Chen on her years of hard work on this challenging complex! https://t.co/77epZBAIpV

[Lander Lab @LanderLab]

@AlanRoseman3 @jhschaef Mystery solved. And fascinating! Thanks Alan

[Lander Lab @LanderLab]

Let us know if you recognize this complex

[Lander Lab @LanderLab]

@mimi1inh @scrippsresearch My bench skills are long gone…

[Lander Lab @LanderLab]

Proof our lab skills are cutting-edge—both at the microscope and the (pumpkin carving) bench! 🎃🔬 #CryoEM #PumpkinScience @scrippsresearch

[Alessandra Magistrato @Magistrato_Lab]

Ready for the final day of the BPS meeting on 'Emerging Theoretical Approaches to Complement Single-Particle Cryo-EM' in Trieste! 🔬 We had outstanding speakers, great science, and friendly atmosphere. Thanks to @BiophysicalSoc @cecamEvents, @palermo_lab @RommieAmaro @LanderLab!

[Doug Kojetin @DougKojetin]

Apply now and come work at @VanderbiltU with me and my outstanding colleagues in the Center for Structural Biology! Would be thrilled to recruit more #NMR friendly colleagues! 😉🙌 @VanderbiltCSB @VandyBiochem @VUBasicSciences

[ludo @ludovic_autin]

Mesoscale Explorer https://t.co/mCQg0vEaqN Paper out !! Excellent work with @asrmoin @dsgoodsell  and @sehnaldavid

https://t.co/15r1hCfzkm

[Lander Lab @LanderLab]

Some thoughts on the current state of single particle cryo-EM map/model validation. (TLDR: preferred orientation remains a big problem, ❤️ Q-scores. There's been progress, but there's still more to do. ) https://t.co/E3jcBOyeKA

[Alessandra Magistrato @Magistrato_Lab]

The registration deadline of the meeting "Emerging theoretical approaches to complement single-particle cryo-electron microscopy" is today!
Join us in Trieste, Italy, with an outstanding list of speakers. https://t.co/Z52t2rT8oF
Pls RT & Apply !

[Lander Lab @LanderLab]

@RubinsteinJohn @GonenShane @jzhaosbp Grid factory set up in La Jolla thanks to @RubinsteinJohn & @jzhaosbp! Efforts spearheaded by @lalexandrescu1, carbon or gold with a bunch of different hole sizes and spacing. Come by any time @GonenShane !

[Lander Lab @LanderLab]

We always thought nucleotide state strictly defined AAA+ conformation, but Jeff Mindrebo's work on mito LONP1 suggests more is at play - substrate interactions also drive protein translocation! Revisiting & rethinking the hand-over-hand mechanism: https://t.co/sUtO4VVbI1

[Lander Lab @LanderLab]

@CrollTristan Finally getting around to using this, very pleased with the implementation. Thanks Tristan! Is it possible to color the residues according to Q-score like in the OG Chimera plugin?

[Jennifer Cash @Jen_Cash_11]

Hey all new(ish) structural biology PIs out there - I started a slack workspace geared toward us! If you’d like to join, DM me your email and method(s) of choice, and I’ll add you to the group.