Larkspur Biosciences

Destroying tumors by targeting cancer cell fitness.

[Larkspur Biosciences @LarkspurBio]

Announcing the first participant has been dosed in the Ph1 study for LRK-4189, a 1st-in-class targeted protein degrader of the lipid kinase PIP4K2C for the treatment of microsatellite stable (MSS) colorectal cancer (CRC). Learn more https://t.co/VkL1HNXG2l

[Larkspur Biosciences @LarkspurBio]

We’re proud to present new data at #SITC2025. We will share preclinical research on our lead candidate, LRK-4189, which we anticipate advancing into a first-in-human clinical study soon.

Abstract: https://t.co/3eDGOEBQxC #ColorectalCancer @sitcancer

[Larkspur Biosciences @LarkspurBio]

Don't miss @drughunter_com 's case study of our lead candidate, LRK-4189. ➡️ https://t.co/gtDlmT2pYO

#biotech #cancerresearch #colorectalcancer

[drug hunter @drughunter_com]

LRK-4189: A Potential First-in-Class PIP4K2C Degrader Heads to the Clinic | https://t.co/0TG8TLqzom

PIP4K2C has minimal catalytic activity, but reported scaffolding roles make it well-suited for targeted degradation.

Building on insights from tool inhibitors and an academic degrader, Larkspur optimized a CRBN-recruiting molecule, LRK-4189, now planned for first-in-human study in MSS colorectal cancer.

Ex vivo CRC spheroid responses, supportive once-daily PK/PD, and xenograft proof-of-concept underpin the program.

Read it on Drug Hunter: https://t.co/0TG8TLqzom

[Larkspur Biosciences @LarkspurBio]

While at the #NYSE for a Biotech CEO Sisterhood event, CEO Catherine Sabatos-Peyton discussed our cancer cell fitness approach with @BiotechTV’s @bradloncar.

➡️ Watch the full video at: https://t.co/MQZrpUQxoM
#Cancer #Biotech #CancerResearch

[BiotechTV @BiotechTV]

𝐁𝐢𝐨𝐭𝐞𝐜𝐡 𝐂𝐄𝐎 𝐒𝐢𝐬𝐭𝐞𝐫𝐡𝐨𝐨𝐝 𝐚𝐭 𝐍𝐘𝐒𝐄: Catherine Sabatos-Peyton is leading @LarkspurBio, a company targeting cancer cell fitness.

Full video: https://t.co/L1NsVihL7b

[Larkspur Biosciences @LarkspurBio]

Thanks to @MaverickNY of Biotech Strategy Blog for her insightful take on why PIP4K2C stands out as a cancer fitness target and how LRK-4189, our 1st-in-class degrader of this lipid kinase, has the potential to treat MSS CRC. #Biotech #Cancer

[Sally Church @MaverickNY]

Time to talk turkey on how protein degradation may be a useful strategy for tackling a dark lipid kinase & overcome acquired resistance in CRC. Nice story from @LarkspurBio
https://t.co/H6N3SRXZta

[Larkspur Biosciences @LarkspurBio]

Announcing the discovery of LRK-4189, a 1st-in-class degrader of the lipid kinase PIP4K2C for the treatment colorectal cancer (CRC).

We presented at the MEDI First Time Disclosures: Breakthroughs on New Medicines session at #ACSFALL2025. https://t.co/oGb3fS3eDZ #Cancer

[Larkspur Biosciences @LarkspurBio]

#ACSFall2025 news: we’re presenting on the discovery of LRK-4189, a 1st-in-class degrader of the lipid kinase PIP4K2C for the treatment of microsatellite stable (MSS) colorectal cancer (CRC). @AmerChemSociety Fall Meeting: https://t.co/d37NRoWD3v #CancerResearch

[Larkspur Biosciences @LarkspurBio]

This #NationalCancerResearchMonth, we’re planning for the first clinical trial evaluating our lead candidate & feeling invigorated after sharing data at #AACR. We're proud to be a part of the cancer research community, turning scientific advancements into breakthrough treatments.

[Larkspur Biosciences @LarkspurBio]

Not to be missed from #AACR25: Larkspur presented new preclinical data on two novel programs that disrupt cancer cell fitness. Check out our findings:
✓ Pin 1 degradation https://t.co/SGIVbKzlpX
✓ PIP4K2C degradation in #ColorectalCancer https://t.co/47spUdLzlc
#CancerResearch

[Larkspur Biosciences @LarkspurBio]

We’re at #AACR25! Don’t miss the newest data on our cancer fitness targeting programs designed to alter the state of cancer cells and ultimately destroy tumors.

Abstracts here:
https://t.co/aIZKe9DCkz
https://t.co/bBdwDbvwvg
#CancerResearch #Cancer

[Larkspur Biosciences @LarkspurBio]

Next month at the @AACR Annual Meeting, we will present new research on our drug candidates targeting key cancer cell fitness genes. Abstracts here: https://t.co/aIZKe9DCkz
https://t.co/bBdwDbvwvg
#AACR25 #CancerResearch

[Larkspur Biosciences @LarkspurBio]

Our CEO, @SabatosPeyton, will join a panel of experts discussing “Accessing Technology to Advance the Pipeline” at the @LongwoodLeaders San Francisco CEO forum on Sunday, Jan. 12. More here: https://t.co/7WrEJl7kUm

[Larkspur Biosciences @LarkspurBio]

At Larkspur Bio, we believe in the power of community. We’re grateful to stand with @ls_cares and help make a meaningful impact this holiday season.

Many thanks to our team, which collected contributions for the gift card drive for nonprofit partners. Happy holidays to all!

[Larkspur Biosciences @LarkspurBio]

Earlier this fall, our team volunteered to pack curriculum supplies for the Science Club for Girls. We’re grateful for opportunities like this to help more girls and gender-expansive youth discover the wonders of #STEM. #culture #biotech

[Larkspur Biosciences @LarkspurBio]

Larkspur CEO, @SabatosPeyton, will share her perspective on the impact of the #InflationReductionAct on innovation in drug development at a @Lumanity webinar tomorrow. Register at https://t.co/qAr6hSsEsY #biotech #drugdiscovery

[Lumanity @lumanity]

There's still time to register for next week's #InflationReductionAct webinar bringing together perspectives from #patientadvocacy groups and #biotech professionals to discuss the emerging concerns and explore actionable strategies https://t.co/slJ0VGedfy #IRA #DrugDevelopment

[Larkspur Biosciences @LarkspurBio]

Don’t miss our @sitccancer presentations on key tumor fitness targets:
* new data on our 1st-in-class PIP4K2C protein degrader
* Pin1 degradation as a promising treatment
* how our ML-enabled immune evasion signature models can predict responses to cancer therapy
#SITC2024

[Larkspur Biosciences @LarkspurBio]

Our Pin1 findings and first-in-class degrader program advance understanding of Pin1’s role in fibroblasts AND cancer cells within #cancer.

We will also present how our ML-enabled immune evasion signature models can predict responses to cancer therapies. #cancerresearch #SITC24

[Larkspur Biosciences @LarkspurBio]

#SITC2024: We’re thrilled to share new data on the therapeutic potential of tumor fitness targets PIP4K2C & Pin1.

Our PIP4K2C preclinical study shows that our 1st-in-class protein degrader can specifically target PIP4K2C & reduce tumor growth in CRC patient samples. @sitcancer

[Larkspur Biosciences @LarkspurBio]

We’re excited to share that the @ACSorganic has awarded Larkspur scientist Morgan O’Shea a 2024 Technical Achievement in Organic Chemistry (TAOC) Award. Congrats, Morgan! #MedChem #biotech #ACSFall2024

[Larkspur Biosciences @LarkspurBio]

With today being National Intern Day, we’re pleased to introduce you to our 2024 summer co-ops.

Meet Vishu Agarwal, a sophomore at @cornelluniversity, and Matthew Palmer, a junior at @northeastern. #intern #drugdiscovery #biotech