Laurel Kinman

protein enthusiast | incoming Sandler Fellow UCSF | alum @jhdavislab MIT Biology | she/her 🏳️‍🌈

[Laurel Kinman @LaurelKinman]

@UCSFChimeraX @MariaVCarreira @EMDB_EMPIAR Grateful to my coauthors @MariaVCarreira @barrettmpowell @jhdavislab for all their hard work, and if you want to try out these tools yourself, you can access them at https://t.co/d1NBMskijG and https://t.co/O42HtqBJoq Happy processing, all! (n/n)

[Laurel Kinman @LaurelKinman]

I’m excited to share our latest preprint, where we showcase the development of two computational tools to facilitate the analysis of highly heterogeneous cryo-EM datasets. (1/7) https://t.co/Jx8TnnxWTT

[Laurel Kinman @LaurelKinman]

@UCSFChimeraX @MariaVCarreira @EMDB_EMPIAR We anticipate this tool will have broad utility – there is a need for a more unbiased and higher-throughput approach to determining contour levels. To make this tool accessible, Maria also created a script that lets you predict thresholds directly within @UCSFChimeraX! (9/n)

[Alireza Ghanbarpour @AGhanbarpour]

Thrilled to share our preprint on the structure of a nautilus-like assembly of membrane proteins, HflK/C, that regulate the FtsH AAA protease activity, a key component of bacterial inner membrane protein degradation machinery. (1/n)
https://t.co/5WxG8LqcYH

[Joey Davis @jhdavislab]

So excited to share that an expanded version of @barrettmpowell's #tomoDRGN manuscript is now live at @naturemethods - huge congrats to Barrett on getting this out!! Read more here: https://t.co/nHE0s0JG3a.

[Joey Davis @jhdavislab]

New preprint is live! See how @barrettmpowell conjured #tomoDRGN. Barrett’s heroic effort now gives us one of the key tools needed to visualize structural heterogeneity in cells. Excited for folks to give it a whirl and let us know how it goes. 1/n

[Joey Davis @jhdavislab]

Our detailed cryoDRGN tutorial is now live at Nature Protocols - enjoy!
https://t.co/uopvKVxT8a

[Alireza Ghanbarpour @AGhanbarpour]

I am excited to share my first cryo-EM BioRxiv preprint!

We showed how a closed axial channel in the AAA+ ClpXP protease can regulate enzyme specificity.

https://t.co/IkO6xP48An

[Joey Davis @jhdavislab]

Excited to post a new #cryoEM preprint led by the inimitable (but #twitterless) Alireza Ghanbarpour. Lovely story about how the AAA+ protease ClpXP achieves substrate specificity. TLDR – it “closes the axial translocation channel when not in use” https://t.co/aP4zLvs5mH 1/n

[Laurel Kinman @LaurelKinman]

Very excited to share this, and hoping it will prove a helpful resource!

[Joey Davis @jhdavislab]

Want to try #cryoDRGN, but unsure how to get started? @LaurelKinman, @barrettmpowell, @ZhongingAlong, and @lab_berger provide step-by-step guidance (and new features) in a new protocol pre-print https://t.co/TZkIqPumzv

[Joey Davis @jhdavislab]

Want to try #cryoDRGN, but unsure how to get started? @LaurelKinman, @barrettmpowell, @ZhongingAlong, and @lab_berger provide step-by-step guidance (and new features) in a new protocol pre-print https://t.co/TZkIqPumzv

[Laurel Kinman @LaurelKinman]

Very excited to share what's been occupying my brain for many months -- the data @Jingyu collected is a great case study of how much we can get out of cryo-EM datasets using new heterogeneity analysis tools, and how we can leverage these tools to learn about biological function!

[Joey Davis @jhdavislab]

New #ribosome and #cryoDRGN preprint (https://t.co/UvyjrK0JCS) with our incredible collaborators @Jingyu, @LaurelKinman, @DushyantNJ, and @j_ortega_McGill ❄️🐉. How cells “proofread” assembling ribosomes -- a tweetorial!1/n.