Leendert van Dalsen

PhD student in @groupprocter, University of Manchester.

[Procter Group @GroupProcter]

Check out our latest publication in @ACSCatalysis: Flavin-photocatalysis 💡and a general platform for the C-H functionalization of sulfides. Cyanation, alkenylation and alkynylation - including reaction of biorelevant sulfides and peptides. Well done Alex and Ollie! 🔗⬇️

[Greaney Group @greaneygroup]

Fresh out in @angew_chem, we use arynes to accomplish a C-N arylation of electron-poor anilines, unlocking the aniline C-N bond as a functional handle for arylation. We're really happy to see this out!

https://t.co/IGY1pCyDDl

[⌬ Dylan ⌬ @DyylaanL]

🔥 NEW PAPER 🔥
Lynch and Nolan et al. (2023), “Traceless Thioacid-Mediated Radical Cyclization of 1,6-Dienes”

So glad this is finally online in @JOC_OL - huge thanks to all my co-authors and especially @markpnolan !

https://t.co/Evf35mrG5v

#Chemistry #Radicals

[Procter Group @GroupProcter]

Searching 🔍 for a versatile strategy to access a diverse range of radicals? Look no further 🙅🏽‍♂️; Sulfonium salt acceptors in EDA complexes allow for facile access. Read 📖 more about your new favourite charge transfer ⚡ complexes in our @angew_chem mini-review. 🔗👇

[Procter Group @GroupProcter]

What an amazing day of science yesterday at the #BSM2023! Thank you @AggarwalLab for organising such a great meeting! 🧪🔬

[Leendert van Dalsen @LeendertvanD]

@Vy_Dong_Group Thanks! As with a many photochemical reactions scale up proved difficult - can potentially address by utilising flow photochemistry. Additionally, sulfenylation occurs selectively at the most electron rich arene C-H, so reaction at other positions on the ring is not possible.

[Leendert van Dalsen @LeendertvanD]

A general arene C–H functionalization strategy by electron donor-acceptor complex photoactivation.

#RSCPoster #RSCCat #RSCOrg

[Leendert van Dalsen @LeendertvanD]

@PolyssenaRenzi The UV-Vis spectroscopy was performed at 0.04 M in CH₂Cl₂

[Leendert van Dalsen @LeendertvanD]

@Sushant20211807 Although analogous alkyl sulfonium salts could be synthesised and might even form similar EDA complexes, existing strategies, such as using alkyl pyridinium salts, already take advantage of similar 'redox tag' approaches.

[Leendert van Dalsen @LeendertvanD]

@Sushant20211807 Thanks! Great question, unfortunately, it's not something we've tried. Our goal was to utilise regioselective aryl sulfenylation chemistry to produce EDA complex acceptors that could furnish aryl radicals irrespective of the parent arene's electronics.

[Leendert van Dalsen @LeendertvanD]

https://t.co/20yJKqX5De

[Procter Group @GroupProcter]

Want to perform metal-free arene C-H functionalisation? A sulfoxide, an amine donor and🔵LEDs is all you need! In @NatureChemistry we report triaryl sulfonium salts as acceptors in💡activated EDA complexes as a general approach to the generation and trapping of aryl radicals🔗👇

[Leendert van Dalsen @LeendertvanD]

Massive thanks and congratulations to co-authors @AbhishekDewanji @GEMCrisenza @egassonchem @JRossiAshton!

[Leendert van Dalsen @LeendertvanD]

Delighted to finally have this published! Check out the first paper from my PhD in @GroupProcter in which we describe a general platform to access aryl radicals via EDA complexes.
Out now in @NatureChemistry. https://t.co/J697e8gFL2

[Procter Group @GroupProcter]

Out in @angew_chem, an🧪+💻study with our @UoMMIB collaborators Hay and Leys groups has identified a new disconnection to methionine analogues: vitamin B2-💡catalysis drives the addition of α-sulfur radicals - from simple sulfides - to dehydroAAs. Great work Ollie and Linus!🔗👇

[alex anderton @alxandrtn]

join us!! we're very fun people!! 🧪🥼

[Leendert van Dalsen @LeendertvanD]

@ovopasta

[Leendert van Dalsen @LeendertvanD]

@ovopasta 😈😈

[Procter Group @GroupProcter]

🚨📣Fixed Term (3Y) Lectureship in the group now open! With Giacomo taking up an independent Lectureship at UoM there is a team vacancy: A great opportunity for outstanding🧑‍🔬s, passionate about teaching🧑‍🏫, who aim to pursue an academic career in the future https://t.co/fSpGzitwuV

[Valentina @valentuash]

Out and about with @Schoenebeck_Lab and @AlisonNarayanUM and the rest of the gang from @GroupProcter @mcglackengroup @LcsoLab @CarreiraGroup @morandilab after a wonderful Thursday full of excellent talks at #TETSymp. What a blast! 💥