Here's a first... benzodiazepine prescriptions declined in the past decade.
Lower rates among all clinicians except one group - that I suspect is due to workforce shifts:
https://t.co/FpXiBuzy0h
Transcranial magnetic stimulation (TMS) is one of the few therapies that works in vascular depression.
In a new RCT, it improved cognition after a stroke, using 2 sessions of iTBS per day over 4 weeks:
https://t.co/iagJKCoYUQ
Evidence grade: Moderate (8/10)
Pramipexole lifted treatment resistant #depression with large effect size (0.87) in 48-wk, placebo-controlled augmentation trial of 150:
https://t.co/vByqQgzgUG
Used 2.5mg as higher dose works better in TRD (vs 1.5mg) (but more side effects).
How to use:
https://t.co/UlhF7Gqob9
BrainsWay Reports Positive Results from Multicenter Randomized Study of Accelerated Deep TMS for Major Depressive Disorder (MDD) https://t.co/Oy5utpdcrI
Cobenfy is a cholinergic for schizophrenia, but what about other cholinergics (anti-dementia: donepezil, galantamine; anti-nicotine: varenicline)?
They didn't help psychosis in new analysis, but one in the pipeline has antipsychotic potential: Emraclidine
https://t.co/gt0aZZ3kwv
GLP1 receptor agonists eg Ozempic are now being evaluated for the treatment of major depressive and bipolar disorder, substance use, and schizophrenia…. Part of a pivot in treatment development in psychiatry focusing on targeting metabolic therapies
https://t.co/sHp00JLCXI
@carlos_arnaud@nuevoleon Así es. Existe una tendencia global de utilizar cada vez más protocolos acelerados. Será Lo interesante conocer, conforme se acumule más evidencia, datos de efectividad de las variantes del protocolo SAINT o espectro “SAINT-like”
Transcranial Magnetic Stim (TMS) works in treatment resistant #depression, and a faster version was also effective in this well-designed trial (3 sessions of iTBS per day over 15 days):
https://t.co/wefQhklAeA
How effective? Effect size 0.65, same degree as a benzo in anxiety.
Brain super-foods like blueberries, tomatoes, tea are rich in flavonoids.
Flavonoid-enriched orange juice improved depression more than OJ without flavonoids in this small trial:
https://t.co/HxEXVeYt9p
More on antidepressant foods:
https://t.co/EmNngBB9IX
What works better after 2 failed #antidepressants?
1. Switch to a tricyclic
2. Change to rTMS
Answer: #2 was 6-times more likely to bring #depression to remission in this new RCT of n=89:
https://t.co/HCoYqSRGpF
More updates in Carlat #Psychiatry News:
https://t.co/MmjJe46Z0r
Magnetic Seizure Therapy (MST) equaled #ECT for #depression in new RCT of 73 patients, with fewer cognitive side effects:
https://t.co/JL4AnUyDtZ
MST is not TMS (transcranial magnetic stimulation). Both use magnets, but MST (like ECT) works by inducing seizures with the magnet.
Another study finds esketamine prevents postpartum #depression when used as Cesarian anesthesia, this time in women with no mental disorders (rates of PPD lowered: 18.5% vs 5.2%)
https://t.co/SpGNVjoqRe
One hypothesis: esketamine lowers pain levels after delivery.
Les comparto con mucho gusto que a partir del bienio 2024-2025 iniciaré funciones como #presidenteelecto para la APM. Esto me llena de orgullo y satisfacción. Bienvenidas las ideas que tengan para nuestra Asociación.