Lincoln Shade

MD/PhD | radiology | dementia | genomics

[Lincoln Shade @LincolnShade]

@CrispyWicks I disagree in principle but that’s basically what we plan to do anyway so…

[Lincoln Shade @LincolnShade]

This sport is like a particle collider for dementia research

[Happy Punch @HappyPunch]

New combat sport league where heavyweights just sprint full speed into each other

[Lincoln Shade @LincolnShade]

@francisdeng @curtlanglotz Author should re-frame from fewer number of hours worked to increased time efficiency, given that their conclusion is radiologists won't end up working fewer hours due to increasing imaging study volumes

[Lincoln Shade @LincolnShade]

One exception to this Makary doesn't mention in the above clip is oral antibiotics, which I do think should still require a prescription due to stewardship concerns

[Lincoln Shade @LincolnShade]

https://t.co/tUh3Qf6v9Y

Making more drugs available over-the-counter would be an easy win in healthcare policy. Gives patients more control and reorients physicians as advisors rather than gatekeepers.

[Lincoln Shade @LincolnShade]

@Goldfiinger @grok @intuitivealy @PalmerLuckey @elonmusk MRIs without contrast are routinely done. But many diseases require contrast to be reliably diagnosed. It’s common for patients to get images without and with contrast, images at different time points after contrast is administered, etc., all in a single study

[Lincoln Shade @LincolnShade]

@rankintweets Perfect size for reading all those papers I’m going to get around to soon

[Lincoln Shade @LincolnShade]

@RuxandraTeslo I think it’s appropriate for both PhDs and MDs to use the title doctor within the setting for which their degree and experience applies, and best if neither flaunt the title when engaging in punditry outside their area of expertise.

[Lincoln Shade @LincolnShade]

@RuxandraTeslo I think it’s appropriate for both PhDs and MDs to use the title doctor within the setting for which their degree and experience applies, and best if neither flaunt the title when engaging in punditry outside their area of expertise.

[Lincoln Shade @LincolnShade]

Good thread that on a paper that discusses the complexities of calculating heritability from genome-wide studies of dementia and the problem of phenotypic heterogeneity. This reasoning formed part of the basis of my dissertation

[Dr. Dominic Ng @DrDominicNg]

Thinking Like a Scientist: Definitions

There's something weird going on in Alzheimer's genetics...
In 2010: Studied 1,594 patients → found genetics explains 42% of disease
In 2021: Studied 1,126,563 patients → genetics explains 3%

What's changed?🧵

[Lincoln Shade @LincolnShade]

@DrDominicNg Paper link: https://t.co/Ho2FnMFkEy

[Lincoln Shade @LincolnShade]

@DrDominicNg This reasoning was the basis for my PhD work. We found pretty much what you’d expect — TMEM106B and GRN aren’t significantly associated with Alzheimer’s specific pathology. However, we believe their main associations with dementia are due to LATE rather than FTLD.

[MacKenzie Wyatt, MD @mackwyatt_med]

Our paper is now out in the world!!!!! Useful information for any states looking to switch to genome sequencing for aCF newborn screening to think about how it will impact CRMS/CFSPID diagnoses @DrMeghanMcGarry @LincolnShade

[Lincoln Shade @LincolnShade]

@FeralPHunter Looking thick. Solid. Tate.

[Lincoln Shade @LincolnShade]

@hyperdiscogirl I don't feel this way about "baby" but the ubiquity of "kiddo" in peds irks me

[Lincoln Shade @LincolnShade]

@amcdonk Was once accused of being a liar because I said Huntington was in southern WV rather than central WV

[Lincoln Shade @LincolnShade]

@dschorno I liked that you led with writing graphic memoirs when introducing yourself to me

[Lincoln Shade @LincolnShade]

@telmudic They work from home and live with their parents so this is really them asking mom to have a girl/guy over

[Lincoln Shade @LincolnShade]

@telmudic "I wouldn't let you touch anything in my OR if you had" lol

[Lincoln Shade @LincolnShade]

@telmudic I discovered WWJ when working with one of his brothers, a surgeon.

Bro: "Do you know who WWJ is?"

Me: "no"

Bro: "my opinion of you has risen"