Lindley Darden

[Lindley Darden @LindleyDarden]

#apoe23
John Moult (of CASP fame) and I have a poster with 28 possible mechanisms for APOE4 at #apoe23 conference and a Discord server to critically assess relation to Alzheimer’s Disease. Join us.

[Lindley Darden @LindleyDarden]

#APOE23
My collaborator John Moult is on his way to St.Louis for APOE conference with our poster: Critical Assessment of Disease Mechanisms. I’ll follow virtually.

[Lindley Darden @LindleyDarden]

@zimmerneurolab @AMPADPortal Is there a similar poll to assess support for different APOE4 hypotheses for Alzheimer's Disease?

[Lindley Darden @LindleyDarden]

Informative interview with John Moult about AlphaFold & our MecCog framework for genetic disease mechanisms: “A Deep Dive Into Modeling and Mechanisms”:
https://t.co/uyCxGAgkwV

[Lindley Darden @LindleyDarden]

Our latest paper has just been published:
MecCog: A knowledge representation framework for genetic disease mechanism
Kunal Kundu, Lindley Darden, John Moult
Bioinformatics, btab432, https://t.co/hPq9m3G2sj
Published: 12 June 2021

[Lindley Darden @LindleyDarden]

Glad to see all the work in mechanistic models by philosophers is science #PSAPosters

[Lindley Darden @LindleyDarden]

My MecCog collaborator John Moult is interviewed in this video: Deep Mind's success on protein folding.
https://t.co/v7n6fa5vcs
Next step: discover the mechanisms in which the proteins act.

[Lindley Darden @LindleyDarden]

Why don’t philosophers use slides???
#PSAonCOVID

[Lindley Darden @LindleyDarden]

Our latest paper is now available as a preprint:

[bioRxiv @biorxivpreprint]

MecCog: A knowledge representation framework for genetic disease mechanism https://t.co/5QWB1nVWC8 #bioRxiv

[Lindley Darden @LindleyDarden]

Attending the Advances in Cognitive Systems 2020 virtually this year

[Lindley Darden @LindleyDarden]

Congrats to my grad advisee who just published this paper:
Kalewold, K.H. (2002), “Race and Medicine in Light of the New Mechanistic Philosophy of Science,” Biology & Philosophy 35: 41. Published on line 9 July 2020: https://t.co/L6NQhPYwLo

[Lindley Darden @LindleyDarden]

@StathisPsillos @PhilSciAssoc @PhilSciJournal Yes PSA 1996 was the first conference whose Proceedings were published in the journal Philisophy of Science.

[Lindley Darden @LindleyDarden]

I’m attending the SURe (Scientific Understanding & Representation) Workshop by ZOOM. Working pretty well. I’m pushing: diagrammatic representation of disease mechanisms provides understanding.

[Lindley Darden @LindleyDarden]

Our PLoS paper is now available:
Darden L, Kundu K, Pal LR, Moult J (2018) Harnessing formal concepts of biological mechanism to analyze human disease. PLoS Comput Biol 14(12): e1006540. https://t.co/tJVBZap7WV
Pub: December 26, 2018; Check out https://t.co/9ehe22oqJN

[Lindley Darden @LindleyDarden]

@BertaVerd @philinbiomed @yoginho @EMBOevents @FEBSnews I’ll be interested to know what analysis of mechanism is being used here and see some examples.

[Lindley Darden @LindleyDarden]

#PSA2018 Eric Saidel on chimps & seeing

[Lindley Darden @LindleyDarden]

#PSA2018 Lindley Darden poster 47 on disease mechanisms

[Lindley Darden @LindleyDarden]

#ismb18 #MecCog poster for disease mechanism schemas

[Lindley Darden @LindleyDarden]

See recent preprint under review on disease mechanisms:
Preprint server for biology: bioRxiv

https://t.co/fAXJzsISMz

Harnessing formal concepts of biological mechanism to analyze human disease
Lindley Darden, Kunal Kundu, Lipika Ray Pal, John Moult
doi: https://t.co/fAXJzsISMz

[Lindley Darden @LindleyDarden]

Bill Wimsatt@fPET:”all interesting mechanisms are made of differentiated parts.”