Link Lab

We study and engineer microbial metabolism! Located at the University of Tübingen @uni_tue *The account is run by lab members

[Link Lab @LinkLabs]

🧬 PhD position open! We're looking for someone to engineer E. coli for bioplastic (cyanophycin) production using thermo-switches, CRISPR and metabolomics. If you're into synthetic biology and sustainable bioprocesses — get in touch! #PhDposition #SynBio https://t.co/AjqVFnTUmx

[Link Lab @LinkLabs]

We are hiring! Our lab at the University of Tübingen is looking for a PhD student to work on host-pathogen interactions in ESKAPE bacteria. More info: https://t.co/AjqVFnTUmx

[Link Lab @LinkLabs]

@ACSPublications Thanks @ACSPublications for selecting our article as Editors Choice.

[Link Lab @LinkLabs]

Technically this required metabolomics on ~3,000 samples from an arrayed CRISPRi library.
The bottleneck wasn’t MS or sampling.
It was sequencing the strains after arraying.
Paper: https://t.co/ympOhFCYXq

[Link Lab @LinkLabs]

What happens if you knock down every metabolic gene in E. coli?

We measured the metabolome of 1515 CRISPRi strains.

Result: metabolism behaves like traffic.
Block an enzyme and metabolites pile up upstream. 🚗🚗🚗
New paper 🧵

[Link Lab @LinkLabs]

Example:
Knockdown of ispB increases farnesyl-PP.
Add a carotenoid pathway and get more product. 🟠
Metabolite accumulation can reveal engineering targets.

[Link Lab @LinkLabs]

New paper from our group: Metabolism Influences Fosfomycin Efficacy https://t.co/xkFFJAIxUF

[Link Lab @LinkLabs]

PhD and Postdoc positions opening in synthetic biology, CRISPR genome engineering of bacteria, and metabolomics.
Details and contact here: https://t.co/AjqVFnUsc5

[Link Lab @LinkLabs]

Preprint from our lab: In synthetic nasal communities a single Corynebacterium propinquum strain can exclude Staphylococcus aureus through nutrient competition. https://t.co/s4rfU4kKo9

[Link Lab @LinkLabs]

We are searching PhD students in synthetic biology and metabolic engineering https://t.co/p7xeyPl000

[Link Lab @LinkLabs]

Great collaboration with the @sourjik lab. Check out how isoprenoid biosynthesis, high oxygen and a membrane complex influence E. coli fitness 👇

[SourjikLab @sourjik]

Our paper describing importance of a highly evolutionary conserved membrane-organising protein complex in bacterial respiration is now published in PLoS Biology in its final version https://t.co/vhr7PDGPH1
Congratulations @MariaIsa_perezl !

[Link Lab @LinkLabs]

Our CRISPR screen in E. coli shows that metabolic mutations influence antibiotic action. Pathway-specific bottlenecks cause resistance. Slow growth leads to tolerance. Read more 👉 https://t.co/SR1hxD1to5

[Link Lab @LinkLabs]

New paper from our group: we developed intact protein barcoding, which uses small proteins as a barcode to identify CRISPRi strains with mass spectrometry. https://t.co/02cnUJO8ON

[Link Lab @LinkLabs]

Congratulations Dr. Lubrano 🥳

[Link Lab @LinkLabs]

Our group was featured in the key to my research podcast. There is a short version and a deep dive about our research and episodes with other great scientists from @uni_tue, @Gh_Tabatabai, @EKemen. Check it out: https://t.co/IprmumOijd

[GASB SynBio @gasb_synbio]

Don't miss the #GCSB Conference⏰!  With less than a month to go, it's time to secure your spot and explore the latest advancements in synthetic biology📅.
Check out the now published poster program and get your tickets right here👇
https://t.co/UtIdzjaANM

[Link Lab @LinkLabs]

Two-stage bioprocesses could overcome many limitations in bioengineering. Check out our review about this exciting topic👇 Led by @paulsimv. Thanks for the nice collaboration. https://t.co/yNc9NNbYYM

[Link Lab @LinkLabs]

@JorgStulke @WarnekeRobert @ThorbenSchramm @JBacteriology @uniGoettingen @uni_tue @SPP1879 Great work and thank you for the collaboration