Lizzie

She/Her ✨

[Lizzie @LizzieGoodison]

i feel like finding new dentists, doctors and hairdressers that your mum doesn’t go to is actually the true meaning of adult life

[𐌁𐌉Ᏽ 𐌕𐌉𐌌𐌉 @OrevaZSN]

We're in a weird era where a guy gets publicly shamed for running his sprinklers on a Tuesday, while a data center the size of a Costco quietly drains a reservoir so AI can generate a picture of your cat as a medieval knight. And the data center gets a tax incentive for it.

[Stephanie Ⓥ @SVcrazycatlady]

You have to choose.

You can have ChatGPT, or you can have water.

You can have Claude, or you can have clean soil.

You can have Grok, or you can have a survivable future.

You cannot have both.

[meredith @noyeahobviously]

“Testing positive for pregnancy” is an in interesting way to say “being raped and impregnated by ICE agents”

[Lizzie @LizzieGoodison]

Why is SJM the most relatable person I’ve ever heard speak, I’m on the edge on tears throughout this podcast and I’m laughing along when she laughs, I LOVE her

[Lizzie @LizzieGoodison]

Sione winding England up and especially Henry Pollock at every opportunity is SENDING ME

[Lizzie @LizzieGoodison]

Odds on Scotland fully collapsing at the 60th minute? I’m too burnt from previous tests 🥺😭

[miss andrist ༻𓆪 ⎠꧂• @mkwest1005]

could just be me, but i think we have a few bigger fish to fry? like perhaps the raging and growing fascism but idk

[Andrew McNair @AndrewMcNair85]

Townsend has taken us from 5th to 9th in world rankings. Never finished better than 3 in six nations and gone out at group stage of two word cups. Why is he still there? #Scotland

[Lizzie @LizzieGoodison]

Once again I would like to remind SRU that Franco Smith exists and Gregor clearly is more bothered about bloody Newcastle than Scotland

[Lizzie @LizzieGoodison]

GEORGE FUCKING HORNE I LOVE YOU

[Lizzie @LizzieGoodison]

Finn has lost his fucking mind, ur LINEOUT IS CRAP

[Old Downbadians RFC @OldDownbadians]

Wee Darcy Graham is at serious risk of drowning in a puddle

[Aakash Gupta @aakashgupta]

This isn’t a random scientist who got lucky.

Mariano Barbacid discovered the first human oncogene in 1982. He isolated H-RAS from bladder cancer cells and proved a single point mutation could trigger cancer. That finding launched the entire field of molecular oncology.

KRAS mutations cause 90% of pancreatic cancers. For 43 years, oncologists called KRAS “undruggable” because the protein had no obvious binding pocket. Barbacid spent the last decade using genetically engineered mice to systematically test every node in the KRAS signaling pathway, looking for combinations that would work without killing the patient.

The triple therapy blocks KRAS three ways at once: the main growth signal, the escape routes through EGFR and HER2, and the stress-response backup through STAT3. Cut the engine, seal the exits, disable the emergency system. Tumors vanished in mice and didn’t return for 200+ days after treatment stopped.

Pancreatic cancer has a 13% five-year survival rate. 8% for the ductal adenocarcinoma type this therapy targets. Most patients live one year after diagnosis.

The catch: this is preclinical. Human trials are 3+ years away. One of the drugs, RMC-6236, might get approved this year, but the full triple combination has regulatory hurdles.

Still. The man who discovered human oncogenes in 1982 may have just figured out how to eliminate the cancer those genes cause. That’s a 43-year arc from first principles to potential cure. Science rarely works this clean.

[Lizzie @LizzieGoodison]

Idgaf get Franco the Scotland job now

[Lizzie @LizzieGoodison]

FUCK YES GLASGOW

[Lizzie @LizzieGoodison]

TMO is having a stellar 5 minutes

[Cllr. Chloe H 💚🇵🇸 @chlveh]

i will never forgive society for acting like asylum seekers, refugees, and homeless people as criminals as if the only thing that separates us and them is luck

[Lizzie @LizzieGoodison]

Being a massive Scotland fan, and recently returned from living in New Zealand for two years is REALLY gonna test my loyalties next week

[Lizzie @LizzieGoodison]

If Portia Woodman-Wickliffe doesn’t score on what’s likely her last match in a black ferns jersey I’ll be so sad for her 🥹

[Lizzie @LizzieGoodison]

Obsessed with these ABs and now very scared for November when they come to Murrayfield 🥺