Gabriel Loeb

Seeking molecular mediators of kidney disease through human genetics, genomics, and novel experimental models. @UCSF, @UCSFNephrology

[Gabriel Loeb @LoebLab]

Polycystic kidney disease is the most common monogenic cause of kidney failure and affects over 10 million individuals. We've known most PKD is caused by mutations in PKD1 for over 30 years. But how PKD1 prevents disease has remained mysterious, limiting effective therapy.

[Gabriel Loeb @LoebLab]

@kidney_boy We should limit extrapolating these data to patients undergoing nephrectomy for tumors. Kidney donors are selected for absence of kidney disease and kidney disease risk factors (description of the donors below). Patients undergoing partial nephrectomy don't look like this.

[Gabriel Loeb @LoebLab]

Thank you to @kidneyomicsamps and @MagdalenaRiedlK for the thoughtful editorial on our paper functionalizing 𝘗𝘒𝘋1 variants and implications for polycystic kidney disease (ADPKD) genetic testing and treatment. DOI: 10.1681/ASN.0000001174 https://t.co/ll6w6ZHVvX

[Gabriel Loeb @LoebLab]

We are constantly thinking about how to integrate human genetics and better experimental models to identify the mechanisms of human disease @UCSFNephrology, @IHG_at_UCSF, @UCSFDOM . Funding for the next generation of medicine from @NIH.
Critiques and feedback welcome!

[Gabriel Loeb @LoebLab]

Polycystic kidney disease is the most common monogenic cause of kidney failure and affects over 10 million individuals. We've known most PKD is caused by mutations in PKD1 for over 30 years. But how PKD1 prevents disease has remained mysterious, limiting effective therapy.

[Gabriel Loeb @LoebLab]

@BrandesNadav, Fnu Ritu, @yimmieg @ReiterLab @willowcoyote.

https://t.co/kfm083BV4x

[Matt Lanktree | #NephroGenetics @MattLanktree]

What an awesome session on common variant CKD genetics @ASNKidney #KidneyWk @kidneyomicsamps @LoebLab @LimdiNita

[Sol Carriazo, Neph. @Nefrontera]

Nice talk by @LoebLab at #KidneyWk!

-Approved targeted therapies for monogenic kidney disease
-Next generation therapies for genetic disease

[Anuja Java, MD (she/her) @anuja_java]

Incredible session on Genetics in Kidney Disease #KidneyWeek @ASNKidney

Outstanding organization & insightful talks by @Vishal_D_Patel #DanielGale #AliGharavi #GabrielLoeb

Grateful for the opportunity to present on Genetics of TMA🙏

Thx #ArleneChapman & #EmilieCornecLeGall

[Gabriel Loeb @LoebLab]

Thank you @ASNKidney! Our lab is very grateful to receive the 2025 Carl W. Gottschalk Research Scholar Grant. Read more about the work here: https://t.co/GwrWZYe7Hf.

[Gabriel Loeb @LoebLab]

@KSusztak @UCSFNephrology Grateful for the chance to learn from @ksusztak, @parkercwilson, and others @Penn and @PennKidney. So much science to be excited about.

[Katalin Susztak @KSusztak]

#Whyscience Day51🧠✨A strong finish to our Renal Grand rounds series by a rising star physician scientists ⁦@LoebLab⁩ ⁦@UCSFNephrology⁩ Pushing the frontiers of kidney genomics and single cell omics. The future of nephrology is bright🔆

[Gabriel Loeb @LoebLab]

Are you content with your current chance of developing Alzheimer’s disease?

[Gabriel Loeb @LoebLab]

Steven Pinker:
And if you’re still skeptical that universities are worth supporting, consider these questions: Do you think that the number of children who die every year from cancer is just about right?