Longevity Decoded

🧬 Longevity Decoded | Cambridge, UK
Turning complex aging research into protocols you can actually use
📈 Evidence-based biohacking | No BS, just biomarkers

[Longevity Decoded @Longevity0S]

🧵 THREAD: The 5 biomarkers that predict your lifespan better than your doctor

Most people track weight and blood pressure while ignoring the metrics that actually matter for longevity.

Here's what to test (and optimize) instead ⬇️

[Longevity Decoded @Longevity0S]

The uncomfortable reframe: aging science spent decades confirming a narrative it had already assumed.

Decline is real. It's also not inevitable for everyone, and the gap between who declines and who doesn't is increasingly explainable.

That's worth building around. #Longevity

[Longevity Decoded @Longevity0S]

🧵 Longevity science has a study design problem. For decades, researchers measured aging by tracking decline. So naturally – they found decline. A new Yale study asks a different question and gets a very different answer.

[Longevity Decoded @Longevity0S]

Layer in the BJSM data from this month: 147,000 people, 30 years, and 90 minutes of resistance training per week cuts all-cause mortality by 13% – with no extra benefit beyond 2 hours.

The inputs required to be in the "improving" group are not extreme. They're just consistent.

[Longevity Decoded @Longevity0S]

Millions of older adults take glucosamine for joint pain. It was considered harmless.

A new Nature Metabolism study (12 years of EHR data, AI-analysed) found a 25% higher likelihood of progressing from mild cognitive impairment to Alzheimer's.

Harmless isn't the same as neutral.
#Longevity

[Longevity Decoded @Longevity0S]

The longevity space has spent years either demonising TRT or evangelising it. The evidence sits somewhere more interesting – and more useful – than either camp.

Going to cover this territory properly going forward. The decisions men are making here deserve better than the noise.

#Longevity

[Longevity Decoded @Longevity0S]

🧵 For years, the standard advice to men considering TRT was: "be careful – possible heart risk."

In February 2025, the FDA quietly removed that black box warning. Most men over 50 making decisions about their testosterone haven't heard this.

Here's what changed – and what didn't.

#Longevity

[Longevity Decoded @Longevity0S]

The honest picture for a man over 50 with confirmed low testosterone: MACE risk is not the argument against TRT anymore.

The arguments that remain are erythrocytosis, arrhythmia monitoring, and whether your levels actually warrant it – or whether you're treating a number, not a symptom.

[Longevity Decoded @Longevity0S]

GLP-1 users had less than half the mortality rate of non-users in a UC San Diego colon cancer study. Half.

The mechanism isn't confirmed – anti-inflammatory effects, insulin signalling, metabolic changes are all candidate explanations.

Real-world signal. Still needs a clinical trial before anyone calls this proven.

#Longevity

[Longevity Decoded @Longevity0S]

The honest position: senolytics may prove to be genuinely transformative. The biology is serious. But right now, the human evidence is a collection of small, mostly uncontrolled pilots.

Anyone already cycling D+Q is making a bet on mouse data and mechanism. That is worth knowing clearly.

[Longevity Decoded @Longevity0S]

The science behind senolytics is some of the most compelling in longevity biology. Zombie cells accumulate with age, drive inflammation, and wreck tissue function.

Drugs that clear them extend lifespan in mice – repeatedly, independently, across labs.

So why is the human evidence so thin? 🧵
#Longevity

[Longevity Decoded @Longevity0S]

There is also no financial incentive for any organisation to run the definitive trial. Dasatinib is off-patent. Quercetin is a widely available supplement.

The clinical trials that exist are driven by research institutions scraping together philanthropic funding.

That is a structural problem, not a scientific one.