Lucie C

Medicine student, dancer

[Lucie C @Lucie_Cer]

@Brandon_Beaber Looks like it's the best one so far in terms of activity

[Lucie C @Lucie_Cer]

All-New EarFun Air Pro 4 | Early Bird Special https://t.co/6OiMqlIcPr

[Lucie C @Lucie_Cer]

@santiagotizio @Brandon_Beaber If u look at the data published 600mg IV and 920mg SC both have very similar AUC/max concentrations so bioavailability is lower apparently

[Dr. Brandon Beaber @Brandon_Beaber]

This interesting pilot trial in multiple sclerosis found that Ocrevus did not reduce Leptomeningeal and paravascular and dural enhancement (inflammation over the surface of the brain and around blood vessels). Does this explain drug failure in some? https://t.co/1Kg2gp6AYC

[Multiple Sclerosis News Today @MSNewsToday]

Columnist Ed Tobias comments on the week's MS news, including a Phase 3 clinical trial of Ocrevus delivered by subcutaneous injection. https://t.co/3nAMV0kzrJ

#multiplesclerosis #msnews #msawareness #thisisms #mslife #mscommunity #mssupport

[Lucie C @Lucie_Cer]

@VictoriaSykes1 If Ocrevus didn't work for u and Tysabri did chances are your MS is rather T cell mediated. In that case Lamtrada could be best option as it depletes T cells quite well, and it's not long term immunosupression like Ocrevus/anti-CD 20s in general.

[Lucie C @Lucie_Cer]

@Dr_Overas @Brandon_Beaber True...forgot it wasn't randomised trial. Wonder if there will be any difference except probably higher ADAs with rituximab.

[Lucie C @Lucie_Cer]

@Brandon_Beaber Interesting...there have been several studies lately supporting this hypothesis. Can't remember if any of them looked at it's impact on progression (which I believe is the main reason for doing double/triple dose trials).

[Lucie C @Lucie_Cer]

@antikeynes @Brandon_Beaber I guess nobody's really interested in doing (sponsoring) a study that most likely won't show huge difference between lower/higher efficacy drug.

[Multiple Sclerosis News Today @MSNewsToday]

One-year data from EMBOLD, a Phase 1/2 study of Atara’s ATA188 for nonactive progressive forms of MS, are now expected in early November. https://t.co/a3XURBsf5X #news

[Lucie C @Lucie_Cer]

@addzr74 Sunrise

[Lucie C @Lucie_Cer]

@weesr10 @slipperywords @RachelHorne19 Basically...think it will depend on place you get it at as well. In my hospital you come and they have to prepare it in the pharmacy 1st (same w IV but there u have to wait bc prior IV steroids anyways). Once it's prepared it takes 10 mins and u go home.

[Lucie C @Lucie_Cer]

@RachelHorne19 @slipperywords Which one do I prefer - not sure. I don't mind spending few hours in hospital twice a year. With injection, I had sore injection site (stomach) for about a week bc it's huge bulk of liquid. But not huge difference for me given the infrequent dosing.

[Lucie C @Lucie_Cer]

@RachelHorne19 @slipperywords At hospital. I don't think I'll be allowed to do it at home (even later outside trial) on regular basis, considering SC natalizumab isn't either. And you still have to take premeds like with IV, although orally.

[Lucie C @Lucie_Cer]

@slipperywords @RachelHorne19 They have a machine that slowly pushes the liquid under your skin.Application may be faster but the actual time when the drug reaches its max concentration in blood is slower with SC administration (within days), which makes immediate side effects rather milder IMO (I had none).

[Lucie C @Lucie_Cer]

@themsguide @lauradonut Yes, I'm in this study. I guess they made SC version bc patnet/lowering hospital costs. But I hope SC might have the edge on IV bc gets better in lymph nodes. Good they made it higher dose (920mg), unlike SC Tysabri.

[Lucie C @Lucie_Cer]

@mscntybrownie @themsguide No reaction whatsoever besides sore injection site for couple days(it's huge bulk of liquid unlike typical injection that has to be absorbed).Guess some people might have reactions similar to IV Ocrevus(which I didn't get either)that's why you get premeds (steroids/antihistamine)