LukeGilbert

Core Investigator at Arc Institute and Associate Professor at UCSF

[LukeGilbert @LukeGilbertSF]

Cells mitigate damage to DNA in surprising ways. Using a series of CRISPRi chemogenomics screens, we identified a PRDX1-dependent iron–damage axis in the DNA damage response.
Congratulations to Tom, Abe, Shaheen, Josep and all co-authors!

https://t.co/TrtzP2T9Bw

[LukeGilbert @LukeGilbertSF]

Interested in predictive modeling for biology? Check out Arc's 2026 Virtual Cell Challenge!

[Arc Institute @arcinstitute]

The 2026 Virtual Cell Challenge has begun! Submissions and the leaderboard are now open.

This year's task: multi-context generalization and zero-shot prediction. Models will need to predict perturbation responses in cellular contexts with no Challenge-specific training data.

https://t.co/JESPsrjWNr

[LukeGilbert @LukeGilbertSF]

@_AndrewLeduc @arcinstitute I am super excited to work together!

[Patrick Hsu @pdhsu]

it is hard to get @SKonermann to do media - she is a true lab rat - so I am excited for more of the world to hear from her directly!

[LukeGilbert @LukeGilbertSF]

I never thought we would be working on Vitamin E but unbiased CRISPR screens take you into unexpected biology. I am delighted to present our work on how mTORC1 activity suppresses ferroptosis through a SCARB1-dependent HDL-Vitamin E uptake pathway. Congratulations to Tom and all co-authors!
Paper:
https://t.co/FHwFSJlj87

[LukeGilbert @LukeGilbertSF]

@bloodgenes @lrbzldz @hhmi_science @DanaFarberNews @BostonChildrens @broadinstitute @GRO_Broad @JswLab @theclotthickens very cool! hope this leads to new therapeutic opportunities. congratulations to all the authors!

[Vijay Sankaran @bloodgenes]

❓A one-time, durable, and even reversible way to prevent thrombosis? In this preprint, led by @lrbzldz, we show that epigenome editing of 🩸 #StemCells can durably reprogram platelet function: https://t.co/bioSZhRFuG

[LukeGilbert @LukeGilbertSF]

We mapped gene interactions across different environmental conditions (GxGxE) at scale for the first time in human cells. These maps lead to the realization that many genes function in a context dependent manner which provides insight into how humans have relatively few genes but many cell types. Congratulations Ben!
Paper:
https://t.co/w5bYZUUK4n

[LukeGilbert @LukeGilbertSF]

I am so excited to see epigenetic editing (CRISPRoff) move forward as a new approach in medicine through this clinical trial. We hope to make a difference for folks with HBV. Congratulations on a big step forward to all who made this possible!
https://t.co/3Lkc7m3XL5

[LukeGilbert @LukeGilbertSF]

Invested in high content CRISPR screening and predictive models? Come to Perturb2026 (March 18/19 2026 in Vienna)! I am co-organizing this conference and am greatly looking forward to what promises to be a fantastic meeting.
https://t.co/FhAY7y1YuR

[LukeGilbert @LukeGilbertSF]

Too many men die of prostate cancer. We miss you John. We discovered a new way of attacking androgen receptor driven prostate cancers that will lead to new therapeutics. This was a wonderful collaboration with @li_haolong and Felix Feng (rest in peace).
https://t.co/24bBKLdWus