Zack Brown

100% speedrunning the Critique of Pure Reason: | PhD candidate | Buffalo Poet | Bad (good?) friend | Nothing-Knower

[Zack Brown @LuminanceBloom]

Being and Time 100% Speedrun is under way! Join me every weekday on Twitch or catch Youtube versions at this playlist here: https://t.co/xxcHAVxGBx

[Zack Brown @LuminanceBloom]

it’s because this song came out when I was a kid so it feels ancient but songs that came out when I was a teenager don’t

[Zack Brown @LuminanceBloom]

it’s weird how time works because 25 years for this song feels more recent than it should be but songs from like 2008 being almost 20 years old blows my mind

[Zack Brown @LuminanceBloom]

the stupidest thing about this is it means the Sabres absolutely could have won the cup lol

[john @johnsemley3000]

it is so hard to root for Buffalo sports teams and not believe that outcomes are being decided by some external, cosmic force. and yet the outcomes themselves are proof that the universe is godless and without grace? quite the quandary!

[Pyres @nonchalantly_]

"formalism" is a useless term and heuristic because you still have to distinguish good and and bad form

[Zack Brown @LuminanceBloom]

it's true!! why would I lie to you!!! https://t.co/fli8fPQoz4

[Zack Brown @LuminanceBloom]

In the most famous short story in Canadian literature, Roch Carrier describes his childhood in Quebec—where he was bullied by his classmates for wearing a Buffalo Sabres sweater (rather than a Montreal sweater) to school! Only this game tonight can repair the wreckage of history!

[Zack Brown @LuminanceBloom]

Now that the Buffalo Sabres have won their first playoff game in 14 years, I am starting a daily thread of reasons that they should win the Stanley Cup this year

[Zack Brown @LuminanceBloom]

(7) In the most famous short story in Canadian literature, Roch Carrier describes his childhood in Quebec, where he was bullied by his classmates for wearing a Sabres sweater (rather than a Montreal sweater) to school! Only this game tonight can repair the wreckage of history!

[Zack Brown @LuminanceBloom]

Now that the Buffalo Sabres have won their first playoff game in 14 years, I am starting a daily thread of reasons that they should win the Stanley Cup this year

[Zack Brown @LuminanceBloom]

The first time the Sabres made the Stanley Cup finals in 1975, they were propelled by “The French Connection,” a legendary line of forwards all from Quebec. At the same time, Foucault, Derrida, and Michel Serres all held appointments at the University at Buffalo. Coincidence? NO!

[Zack Brown @LuminanceBloom]

clearly i do need to keep doing this 🥰

[Zack Brown @LuminanceBloom]

I forgot to keep up with this thread but we gotta get it going again lest the Sabs are eliminated today 😔😔😔

[Zack Brown @LuminanceBloom]

The first time the Sabres made the Stanley Cup finals in 1975, they were propelled by “The French Connection,” a legendary line of forwards all from Quebec. At the same time, Foucault, Derrida, and Michel Serres all held appointments at the University at Buffalo. Coincidence? NO!

[Zack Brown @LuminanceBloom]

game changing for hockey players

[Anish Moonka @anishmoonka]

You only get two sets of teeth. Then a protein called USAG-1 tells your jaw to stop making more. A Japanese team has been testing a drug to block it since October 2024. Phase 1 finished without serious side effects in February.

The trial began at Kyoto University Hospital. Thirty men signed up, ages 30 to 64, each missing at least one back tooth. They each got a single IV dose of TRG-035, an antibody made by Toregem Biopharma, a Kyoto University spinoff. The drug shuts off USAG-1. With that protein out of the way, your jaw’s growth signals start telling sleeping tooth cells to wake up.

It started with mice. In 2007, researchers found a strain born with extra teeth and traced the cause to a missing USAG-1 gene. The protein was the brake. By 2021, Dr. Katsu Takahashi’s lab in Osaka had used a USAG-1-blocking antibody to grow new teeth in ferrets born without their full set. The results landed in the journal Science Advances. They later got the same effect in dogs.

The next phase targets children aged 2 to 6 born missing six or more permanent teeth. The condition affects around 1 in 1,000 people. Japan’s Ministry of Health has already given TRG-035 a fast-track status reserved for rare conditions. Phase 3 trials run through 2029. Toregem wants the drug on the market by 2030, with adult tooth loss from injury or decay as the longer-term target.

Around 120 million Americans are missing at least one tooth. A single dental implant in the US runs $3,000 to $6,000, and full-mouth restoration can hit $60,000. The global dental implant market is more than $5 billion a year. Every dollar of it goes to titanium screws drilled into bone. Toregem is testing whether your jaw will grow new teeth on its own once USAG-1 is taken offline.

[Zack Brown @LuminanceBloom]

All baseball teams suck from behind the veil of ignorance

[golden taint @goldentaintIII]

Ranking mlb teams by their all time worst player

[Zack Brown @LuminanceBloom]

athletes love to talk in what I would call the royal third person

"guys are hanging out with each other; guys are supporting each other; guys are getting beers with each other after the game, and that’s why guys have been able to get pressure around the net" etc

[Zack Brown @LuminanceBloom]

you don’t even need to listen to know this band sucks ass

[Zack Brown @LuminanceBloom]

french team puts up a decent fight in the championship round but it gets revealed later that they were match-fixing with their german mentors anyway

[Zack Brown @LuminanceBloom]

german team clears this so hard it's not even close

[Zack Brown @LuminanceBloom]

@brianfauteux Definitely; I'm excited. I was hoping this would be the matchup even though I think TB would have been a safer opponent for us

[Zack Brown @LuminanceBloom]

https://t.co/aggXqhqv0k