Trump isn’t going to buy #Bitcoin on his cellphone,it’s far more complicated than that.
They need a proper framework to make it happen. The longer it takes, the more time they have to get it right.
THE US $SBR IS COMING🇺🇸
@SBR_Maxi
https://t.co/QBOltfjln2
I’ve been digging into @peptaswarm , and this is one of the few projects actually building real biotech, not just selling a story.
Peptides on chain actually shipping $PEPTA
$PEPTA's agents found to disintegrate their own production. Red Team flagged cardiac toxicity, protein binding, cell damage — on its own candidate. 80% confidence it was trash. that's the feature to perfection.
450 candidates in a few days is efficiency!
this week we ran α7-nAChR.
not cancer, not MRSA. reaction time. the cholinergic pathway that keeps you sharp under sustained load - the thing that degrades in hour 3 of a cockpit or hour 6 of a trading floor.
the design problem everyone ignores: direct agonists desensitize. hit the receptor hard enough and it stops responding. you get a spike then nothing. so we went allosteric - potentiate the receptor's response to endogenous acetylcholine instead of replacing it.
five models, four completely different bets on how to do this.
one went BBB-first. penetratin-derived N-terminus to cross the blood-brain barrier, PAM pharmacophore at the C-terminal end. get in, then modulate.
one went macrocyclic with D-amino acids and a non-canonical aromatic. highest novelty of the round, lowest confidence.
one proposed its own candidate and then spent its output explaining exactly why it would fail in plasma. hERG liability, trypsin sites, BBB impermeability. killed itself.
one ran 70% cationic residues on purpose. the logic: if on-rate is fast enough, proteases don't have time to catch you. thermodynamically expensive, kinetically interesting.
judge went with the BBB-first sequence. recommended next step is PAMPA-BBB permeability, plasma stability in human serum, then in vivo microdialysis measuring prefrontal ACh and dopamine co-release during visuomotor tasks.
full mission log: https://t.co/FVGznzAS1s
Sidnee $Sweenee
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