Lydia Rader PhD

Postdoc @IBG_CUBoulder | Genetic epidemiology of chronic pain & mental health

[Matt Rosenblatt @RosenblattMatt]

(10/14) Importantly, genome-wide genetic correlation only told part of the story

Using MiXeR, we found extensive shared polygenic architecture with many disorders—even when overall genetic correlation was small or absent

[Stanford Pain Medicine @StanfordPain]

New data reveal how migraine is more than just head pain:

-About 72% of patients reported pain beyond the head and neck
-More widespread pain was linked to higher pain intensity and less improvement over time
-Higher baseline fatigue was linked to worse symptoms at the start, but greater improvement in pain interference
-PTSD symptoms were not associated with outcomes in this group
-Overall improvements in pain and function were modest

Takeaway:
Assessment of chronic migraine should go beyond headache symptoms. Widespread pain and fatigue may shape how patients respond to treatment.

Source: https://t.co/r8YHN5tg8B

Authors: John A. Sturgeon, Noel Vest, Meredith Barad, Beth Darnall, Sean Mackey

[The Journal of Pain @TheJournal_Pain]

Original: Drs. @LydiaRader, @torwager, Friedman, & coll. used mixed-effects models to examine associations between polygenic scores and adolescent self-reported pain presence, intensity, recurrence, and multi-site pain.

FULL: https://t.co/Q6om9tvzZ8

[Lydia Rader PhD @LydiaRader]

@torwager @Na_Friedman

[Lydia Rader PhD @LydiaRader]

What if some adolescent pain complaints are early manifestations of lifelong chronic pain risk?

https://t.co/CR189eUoqf

[Lydia Rader PhD @LydiaRader]

The genetics of chronic pain may begin manifesting much earlier in development than typically recognized.

[Rajshekar Reddy @Reddy_XX]

Ivan had a spinal cord injury three years ago that left him quadriplegic.

Last week, he ordered dinner from his favorite restaurant by himself.

This level of control used to need brain surgery. Not anymore.

Introducing Click by @axionlabsinc.

[Lydia Rader PhD @LydiaRader]

@Reddy_XX @axionlabsinc So inspiring!

[IBG @IBG_CUBoulder]

📰🚨New paper led by IBG members @LydiaRader and Dan Gustavson reports findings that music engagement at age 12 predicts less alcohol/substance use 5–11 years later, with twin models pointing to protective shared environments rather than direct effects: https://t.co/lDThoaNr5G

[Lydia Rader PhD @LydiaRader]

Overall, music engagement seems to be protective against later substance use. The same kids who are drawn to music may also be at elevated genetic risk, potentially through increased sensation seeking, yet the environmental contexts surrounding music may be protective.

[Lydia Rader PhD @LydiaRader]

New paper! 🎶🎸
• Do adolescents who engage in music use less substances later?
• Are the links direct effects or due to shared genetic/environmental influences?
• Is music constructive for youth at high genetic risk for substance use?

https://t.co/taKMuWp4rz

[Lydia Rader PhD @LydiaRader]

🔹 The GxEs were non-significant, but trending in expected directions. Hence, those at high genetic risk for substance use/sensation seeking did not seem to especially benefit from music.

[IBG @IBG_CUBoulder]

New Nature Communications paper from IBG graduate student Jeremy Lawrence describes high genetic overlap across 73 physical illnesses (e.g., cancers, heart failure, pneumonia) and internalizing, substance use, and neurodevelopment disorders.🧬
https://t.co/KNf0lP3ley