Lysosome Articles

Daily updates on lysosome biology and lysosomal diseases.

[Lysosome Articles @LysosomeJC]

Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr682-phosphorylated APP βCTF

https://t.co/cT36SGPOJQ

[Lysosome Articles @LysosomeJC]

Physical training and high-protein diet improved muscle strength, parent-reported fatigue, and physical quality of life in children with Pompe disease.
https://t.co/sKbWhzE57z

[Lysosome Articles @LysosomeJC]

Improved imaging and preservation of lysosome dynamics using silver nanoparticle-enhanced fluorescence.
https://t.co/ASKSesKuyo

[Lysosome Articles @LysosomeJC]

The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells.
https://t.co/rgsghdjEHX

[Lysosome Articles @LysosomeJC]

Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
https://t.co/IONhUVgEJk

[Lysosome Articles @LysosomeJC]

Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells.
https://t.co/WyJ0sbkUix

[Lysosome Articles @LysosomeJC]

Association of Rare Variants in ARSA with Parkinson's Disease.
https://t.co/WN2UAXNfDJ

[Lysosome Articles @LysosomeJC]

An ATG12-ATG5-TECPR1 E3-like complex regulates unconventional LC3 lipidation at damaged lysosomes.
https://t.co/jtid9OJkoi

[Lysosome Articles @LysosomeJC]

Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration.
https://t.co/8cayabt0e5

[Lysosome Articles @LysosomeJC]

Novel phosphorylation of Rab29 that regulates its localization and lysosomal stress response in concert with LRRK2.
https://t.co/ppa0Fpxx0t

[Lysosome Articles @LysosomeJC]

The chloride antiporter CLCN7 is a modifier of lysosome dysfunction in FIG 4 and VAC14 mutants.
https://t.co/7CZyLmVvyk

[Lysosome Articles @LysosomeJC]

Genetic ablation of Saposin-D in Krabbe disease eliminates psychosine accumulation but does not significantly improve demyelination.
https://t.co/imP3ts4d9J

[Lysosome Articles @LysosomeJC]

Arf1-PI4KIIIβ positive vesicles regulate PI(3)P signaling to facilitate lysosomal tubule fission.
https://t.co/qomtHR6UE6

[Lysosome Articles @LysosomeJC]

Dynamic Measurement of Endosome-Lysosome Fusion in Neurons Using High-Content Imaging.
https://t.co/XCXyOvGE0z

[Lysosome Articles @LysosomeJC]

Efficacy and Safety of Avalglucosidase Alfa in Patients With Late-Onset Pompe Disease After 97 Weeks: A Phase 3 Randomized Clinical Trial.
https://t.co/9ccIm4s5GE

[Lysosome Articles @LysosomeJC]

Lysosomal calcium loading promotes spontaneous calcium release by potentiating ryanodine receptors.
https://t.co/jRSpa6fNzr

[Lysosome Articles @LysosomeJC]

Nanosensor-based monitoring of autophagy-associated lysosomal acidification in vivo.
https://t.co/HgLu8q1PfL

[Lysosome Articles @LysosomeJC]

Local translation in microglial processes is required for efficient phagocytosis.
https://t.co/YqSqZuBmfG

[Lysosome Articles @LysosomeJC]

C9ORF72 suppresses JAK-STAT mediated inflammation.
https://t.co/D5g0merh2N

[Lysosome Articles @LysosomeJC]

Enzyme replacement with transferrin receptor-targeted α-L-iduronidase rescues brain pathology in mucopolysaccharidosis I mice.
https://t.co/ezx2Qyz88p