NICE Guidelines (UK) for SCH in Pregnancy 🇬🇧
📌Treatment threshold is higher than ACOG/Canadian:
🔹Treat only if TSH ≥7 mIU/L, regardless of anti-TPO
🔹No treatment if TSH <7 and FT4 normal
Unless positive anti TPO
Exception: consider LT4 if history of infertility or miscarriage
3️⃣ Approach in General Adults
📌 Based on TSH level and patient context
🔹 TSH 4.5–10 mIU/L
Observe OR treat if:
•Symptomatic
•Positive anti-TPO
•Goiter
•Infertility
•CVD or RFs
•Pregnancy planning
🔹 TSH >10 mIU/L
Treatment is generally recommended even if asymptom
8️⃣ Anti-TPO Positive Women
🔸 Even if TSH is <4.0, anti-TPO + women at risk for progression
🔸 Close monitoring every 4–6 weeks during pregnancy
🔸 Consider LT4 if trying to conceive or history of miscarriage
🔟 Follow-up
•Monitor TSH every 6–8 weeks after starting or adjusting LT4
•In pregnancy: check every 4 weeks in 1st half, then 6 weeks
•Adjust doses as fetus grows or if TSH fluctuates
10. Postpartum Plan:
🍼 GDM usually resolves postpartum
🧪 Reassess with A1c or 75g OGTT at 6 weeks postpartum
🔁 Screen for T2DM every 1–3 years thereafter
✅ Encourage breastfeeding
✅ Lifestyle support to reduce future T2DM risk
75g Oral Glucose Tolerance Test (OGTT) after overnight fast.
📊 GDM = any 1 of the following:
•Fasting glucose ≥5.1 mmol/L
•1-hour glucose ≥10.0 mmol/L
•2-hour glucose ≥8.5 mmol/L
Based on IADPSG/WHO — adopted in Canada.
Diabetes in Pregnancy: A Practical Thread (Toronto Notes 2025)
For Internal Medicine Residents 🩺
Covers GDM, pregestational DM, meds, screening & postpartum care
🔥 Must read thread by @Eb_alabdali
An on-call case where language barrier almost hid a myxedema crisis until he used AI to break through and save the patient.
Brilliant blend of clinical reasoning and tech in action.
👇👇
On-call in the ER: When language barrier almost hid a diagnosis…
I was called to see a 45 y/o woman in the ED.
No medical history on file.
She had dry cough and loss of appetite.
She spoke only Sinhala — and no one around could understand her.
Here’s what happened next ⬇️