Miguel F. Segura

Científico y aprendiz de minimalista

[Gabriel Rufián @gabrielrufian]

Israel es un Estado genocida que ha asesinado a 15.000 niños, ha desplazado a 2.000.000 de personas, ha bombardeado a 4 países y acaba de matar al primer ministro de Yemen.

Todo cuanto se haga para visibilizarlo, denunciarlo y frenarlo está bien.

Te encaje a ti en tu causa política o simpatía personal. O no.

Sobre todo si es desde el sofá.

[Amics Joan Petit @AmicsJoanpetit]

🎉 Comença el compte enrere!
Falta 1 mes per la 25a Festa Torneig Joan Petit a Cassà de la Selva! 🏑 47 clubs 👧🧒 400 nens/es de 3 a 6 anys
❤️ Solidaritat, emoció i valors
📅 7 de juny, no t’ho perdis!
#JoanPetitCassà #FestaTorneig25Anys #amicsjoanpetit #totssomjoanpetit

[Gabriela Guillén @Guillen_CirPed]

🔝Un nuevo hito de @vallhebron como centro pediátrico quirúrgico de alta complejidad de referencia para toda España 👉🏼 PRIMER trasplante pediátrico simultáneo de corazón e hígado del estado https://t.co/RNswqwR2JT a través de @elperiodico #cirugíapediátrica #HOPE

[Jordi Évole @jordievole]

Tómese este monólogo cada 8 horas, contra intolerancias varias, principalmente la catalanofobia.
Que esto se haya emitido en la televisión pública española es la hostia. VISCA Marc Giró. Visca #LateXou y todo su equipo https://t.co/HoeA7mL2H5

[Gaël Roué @gaelroueBCN]

@CarrerasIJC @miranda_f_s @roue_s Grateful beyond words to the magnificent PhD committee—@BellosilloBea, @MF_Segura, and @JoseL_Sardina—for their thoughtful reviews and invaluable insights on the two groundbreaking studies led by Miranda on #CXCR4 targeting in #DLBCL and multiomics characterization of mMK+#MDS.

[Vall d'Hebron Institut de Recerca @VHIR_]

Gràcies a Adan Sáez, pastisser a @Xocosave, per l'impuls a la recerca del grup de Càncer i Malalties Hematològiques Infantils del #VHIR! 👏 Ha donat 7.500 € recaptats amb la venda d'un panettone solidari. @danaeboronat #RecercaPediàtricaVH

[Rafael Irizarry @rafalab]

Biologists, stop putting UMAP plots in your papers!

UMAP is a powerful tool for exploratory data analysis, but without a clear understanding of how it works, it can easily lead to confusion and misinterpretation.

Link to @simplystats blogpost below.

[Vall d'Hebron Institut de Recerca @VHIR_]

El 10/12 se celebró la 1a jornada presencial de trabajo del proyecto @SEHOP2-PENCIL, coordinado por @vallhebron, cuyo objetivo es facilitar el acceso de todos los menores con cáncer a la medicina personalizada, independientemente de su lugar de residencia. #RecercaPediàtricaVH

[Olga Piskareva @0lgaPiskareva]

We are thrilled with @NeuroblastomaUK Award to study mRNA vaccine 4 HR neuroblastoma & collaborate with leading experts @Prof_H_McCarthy @MF_Segura Prof Westermann @DKFZ Prof Gray @unisouthampton Dr Moreno @vallhebron. 🥳 @TissueEngDublin @RCSI_Research @RCSI_Irl @RCSIPharmBioMol

[Vall d’Hebron Institute of Oncology (VHIO) @VHIO]

Expressem el nostre sentit condol a la família i les amistats d’Eudald Morera, empresari i impulsor del festival
@vallviva.
Sempre el recordarem pel seu compromís i suport a la recerca del càncer a VHIO, @vallhebron i @VHIR_
https://t.co/yyQs8nqVUR.
Via @diaridegirona

[Vall d'Hebron @vallhebron]

Expressem el nostre sentit condol per la pèrdua d’Eudald Morera, empresari i impulsor del festival @vallviva, que cada estiu reuneix els artistes més compromesos per recaptar diners per a la recerca en càncer a #VallHebron @VHIR_ ⁦@VHIO https://t.co/TYGEEHCv6b

[Noa Gresiva @NoaGresiva]

Brutal Wayoming sobre lo ocurrido en Valencia. Es para verlo en bucle.

[Laura @Rodraedo]

Esto de @gabrielrufian
Más claro, imposible.
👇👇👇👇👇👇

[Patrycia Centeno @PoliticayModa]

90 años, enfermo de cáncer y sabiendo que le queda poquito, Pepe Mujica se dirige a votar porque “la democracia no es perfecta, pero sigue siendo el mejor sistema (…) Sólo mejorará cuando nosotros mejoremos moralmente. No hace falta adularla, pero sí cuidarla” ✨🫶🏻 #loveMujica

[Emilio Lecona @Emlecona]

La cara de satisfacción por cumplir lo que esperabas y por tener tanta gente apoyándote para llegar a la meta
#yoCorroPorLaCiencia

[Science News @SciencNews]

How To Choose a Good Scientific Problem (1/3)

@MolecularCell #PhD #PhDlife #academics #AcademicChatter #AcademicTwitter #Postdocs #Research #Science

[Pedro Torrijos @Pedro_Torrijos]

Cada vez que hay un huracán en USA, vemos casas de madera derribadas por el viento.
¿Pero por qué construyen así?

Pues porque si lo hubieran hecho de otra manera, no existirían los Estados Unidos y, probablemente, tampoco los rascacielos.

Os cuento en #LaBrasaTorrijos
🧵⤵️

[Andrew Akbashev @Andrew_Akbashev]

Victor Ambros was denied tenure at Harvard.
But he was not a usual PI.

The Harvard Crimson describes:

1⃣ He took an especially hands-on role in mentorship:

“Duan recalled the experience of arriving in the U.S. for his Ph.D. as a non-native English speaker. Ambros spent time personally mentoring Duan in how to write and give presentations in English, which Duan said proved “very helpful.”

Duan said Ambros also taught him how to believe in himself as a scientist.

“Victor is just an intensely curious person, and that curiosity is infectious. You can’t help but be really curious around him because he’s always asking interesting questions and being provoking.” - H. Scott Silverman.

2⃣ He did not step away from lab work to focus on the administrative work and funding, unlike many other professors.

“Victor is NOT a very typical PI because he has his own bench,” Duan said. “He wants to stay closer to the science. He would work side by side with all the other people who were actively doing the same.”

📍Why tenure was denied?

David Baltimore’s opinion (Caltech president, 1975 Nobel laureate):

“The denial of tenure was consistent with Harvard’s hiring junior faculty and then not giving them tenure. The fate of junior faculty at the University was to teach and conduct research — but ultimately be replaced by new junior faculty before they could rise through the ranks. It just underlines the foolishness of that approach to building a great department.”

After Harvard, Victor Ambros moved to Dartmouth and then the University of Massachusetts.

📍 My view:

Tenure track is rarely about with Nobel-level work.

At most universities, tenure requires metrics to be fulfilled. This also includes recommendation letters from peers that should be excellent.

As a result, most professors are VERY careful during tenure track (outside the US too). They avoid risky research and focus on metrics (more papers, more funding, more students, etc). Too much at stake.

The problem is -
Every university wants to have a Nobel laureate but uses a metrics-based system to filter people out.

Instead of encouraging their young faculty members to pursue risky & groundbreaking research, most departments urge them to focus on other things.

❗️ Basically:
Tenure = something feasible, doable, countable
Nobel Prize = once thought infeasible but achieved

I think this gap is what many young scientists are so upset about.

Metrics are great for business, but in science it should be used with great care.

#science #AcademicChatter #chemtwitter

[Centro de Biología Molecular Severo Ochoa @CBM_CSIC_UAM]

This week we have had the pleasure to host 100 researchers from all over at the I Workshop on Chromatin Alterations in Cancer Development. Thanks to the speakers, attendees and organisers @Emlecona & @AnaOrtegaMolin1, and here’s to many more to come!

[CCBD_VH Research Group @CCBD_VHResearch]

Last week at the #18JornadaCientificaVH, Dr. Josep Sánchez de Toledo and Dr. Lucas Moreno, head of our group, shared insights on 30 years of #progress in #childhood #cancer #research at @VHIR_. Exciting #advancements and a bright #future ahead!
#30anysfentVHIR #pediatriccancer