MSB Lab

[MSB Lab @MSBLabIITI]

A potential drug target to treat liver scars caused by alcohol https://t.co/ecNmWXk566

[MSB Lab @MSBLabIITI]

Pleased to share our latest work published in ASPET Discovery!

“Mechanistic insights into toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) in cancer”

https://t.co/uyrs7w3m35

In this work, we provide a comprehensive overview of the emerging role of TIRAP as a critical signaling hub connecting pattern-recognition receptor activation with chronic inflammation, tumor progression, and therapeutic resistance across diverse cancers.

I am grateful to the MSB Lab team and our collaborators for their dedication, hard work, and valuable contributions to this work.

We look forward to building on these insights to further understand innate immune signaling and its role in cancer progression and therapy response.

— MSBLabIITI

[MSB Lab @MSBLabIITI]

Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) in Hepatic Stellate Cells: Beyond Membrane and Cytoplasmic Presence.

For years, we’ve known TIRAP (also called MAL) as a protein working strictly at the cell membrane to handle immune signals. But our team just found something completely unexpected: it actually moves into the nucleus during alcohol-induced liver damage.

What we found:

Moves to the nucleus:
Alcohol and LPS exposure activate TIRAP, leading to its translocation into the nucleus of hepatic stellate cells.

Activates HSCs:
Nuclear TIRAP promotes HSC activation and contributes to ALD progression.

Drives liver scarring:
Inhibition of TIRAP significantly reduces α-SMA and collagen, two key markers of hepatic fibrosis.

https://t.co/rOBgnDJg6z

These findings highlight a promising new therapeutic target for chronic liver disease and fibrosis.

Congratulations to the entire team at IIT Indore, collaborators, and colleagues.

-MSBLabIITI

[MSB Lab @MSBLabIITI]

MSB Lab welcomes our new https://t.co/2ftczAb73e. project students!

Wishing Sadhana, Shurti, Vansh, Ashmal, and Arbaz a productive and rewarding thesis journey ahead!

— MSBLabIITI

[MSB Lab @MSBLabIITI]

Pleased to share our latest work published in Frontiers in Bioengineering and Biotechnology!

"Engineering nanoparticles for macrophage reprogramming in chronic inflammatory diseases: current advances, challenges, and future perspectives"

-MSBLabIITI

[MSB Lab @MSBLabIITI]

Happy to share that our paper is now published in Frontiers in Cell and Developmental Biology!

Excited to continue uncovering the immune mechanisms underlying liver disease and advancing our understanding of liver fibrosis.

🔗 https://t.co/sYKK77ayyb

– MSBLabIITI

[MSB Lab @MSBLabIITI]

Congratulations, Ms. Shreya, on successfully completing your internship at MSBLabIITI!

We wish you all the very best in your studies, career, and future endeavors.

Best wishes for a bright and successful future!

– MSBLabIITI

[MSB Lab @MSBLabIITI]

A warm welcome to Ms Tanisha, MS (Human Genetics) from University College London (UCL), who joins MSB Lab as a Project Intern.

We are delighted to have you with us and wish you an enriching and rewarding research experience ahead.

Welcome to the team, Tanisha!

– MSBLabIITI

[MSB Lab @MSBLabIITI]

Congratulations, Mr. Aayush, on successfully completing your project thesis at MSBLabIITI!

We wish you continued success in your academic and professional journey.

Best wishes for a bright future!

– MSBLabIITI

[MSB Lab @MSBLabIITI]

Congratulations, Mr. Javed, on successfully completing your Master's program! We are delighted to welcome you to the MSBLabIITI family as a Ph.D. student and wish you a rewarding research journey filled with success, exciting discoveries, and great achievements.

– MSBLab, IITI

[MSB Lab @MSBLabIITI]

Congratulations to our https://t.co/KjdGHcEbJV. project students on successfully completing their thesis at MSBLabIITI Indore!

We are incredibly proud of your achievements and wish you all the best in your future endeavors.

– MSBLabIITI

[MSB Lab @MSBLabIITI]

MSB Lab would like to congratulate Ms. Suha Sultana Shaik on the successful completion of her Summer Internship 2026.

-MSBLabIITI

[MSB Lab @MSBLabIITI]

A warm welcome to Ms. Faaiza Siddiqui, who joins MSB Lab as our PhD student.

We're excited to have you on board and wish you a wonderful research journey.

Welcome, Faaiza! 🎉

-MSBLabIITI

[MSB Lab @MSBLabIITI]

Welcome to MSB Lab, Parth! 🔬

A warm welcome to Mr. Parth Sharma as our new PhD student. Glad to have you with us, Parth!

Best wishes

-MSBLabIITI

[MSB Lab @MSBLabIITI]

MSB Lab is pleased to share that Prof. Mirza Baig recently visited Sapienza University of Rome, strengthening our collaboration with Prof. Aurelia Rughetti and her team.

We wish Prof. Baig continued success in fostering international research collaborations.

– MSBLabIITI

[MSB Lab @MSBLabIITI]

Macrophages in the crossfire of sepsis

Take a look at our recently published article.

Macrophages in the crossfire of sepsis- deciphering immunometabolic reprogramming, autophagy, and novel immunomodulatory therapeutic strategies

https://t.co/FYKBprpOBz

-MSBLabIITI

[MSB Lab @MSBLabIITI]

Take a look at our recently published article.

A Sulfonamide-Based Compound DRZ-V Enhances Wound Repair via Macrophage-Mediated Responses Associated with TIRAP–NF-κB Signaling

-MSBLabIITI

Pharmaceutical Research
10.1007/s11095-026-04131-2
📷
https://t.co/np0H1jzCGA

[MSB Lab @MSBLabIITI]

We are happy to share that Mr. Kundan Solanki has successfully defended his PhD thesis on Mechanisms and Therapeutic Targets in Atherosclerosis.

Congratulations on this achievement and best wishes for his future.👍

-MSBLabIITI

[MSB Lab @MSBLabIITI]

We are delighted to share that our patent has been officially granted.

This invention is part of our ongoing work in anti-inflammatory drug discovery, focused on targeting key molecular pathways involved in both acute and chronic inflammation.

-MSBLabIITI

[MSB Lab @MSBLabIITI]

Take a look at our recently published article.

"Modulating IL-1β-induced pro-atherogenic endothelial responses through drug repurposing"

Inflammopharmacology
10.1007/s10787-026-02229-y

-MSBLabIITI