MacMillan Group

Shining light on organic chemistry and chemical biology

[MacMillan Group @MacMillan_Lab]

Now out in Nature Communications: https://t.co/hwdHxKc7HR

Using µMap, we uncovered the engagement of ERα within PML nuclear bodies following treatment with the hormone therapy, fulvestrant.

Congrats to Chun, Zihan, Ciaran, and our BMS collaborators!

[MacMillan Group @MacMillan_Lab]

Now in @Nature: A novel approach to largely inaccessible dialkyl ether chemical space through heteroatom homolytic substitution (het-Sh2). Huge congrats to the team, Johannes (@GrosskopfJo), Johnny, Jackie, and @Merck collaborators. Give it a read!

https://t.co/6RIJ0mAGYg

[MacMillan Group @MacMillan_Lab]

Cheers to Eva Lin and Lauren Harstad for an awesome Third Year Seminar!

[MacMillan Group @MacMillan_Lab]

Congrats to Jennifer Nguyen and William Zhao for a brilliant Third Year Seminar talk!

[Princeton Chemistry @PrincetonChem]

The David MacMillan Lab @macmillan_lab advances a couple-close strategy to make “the impossible, possible.” Great work Jiaxin (Jay), Will, Johnny, Will, Noriyuki, Alice, Taylor, Chris, Marian, Dave!

Enjoy our story on the lab’s new research in Science: https://t.co/aHbaGFgCBD

[MacMillan Group @MacMillan_Lab]

Cheers to Taehyun (Tae) Kim, Min Sun (Esther) Kang, and Zihan (Blair) Dong for delivering an awesome Third Year Seminar!

[MacMillan Group @MacMillan_Lab]

Happy (early) birthday to Phil and Anna!

[MacMillan Group @MacMillan_Lab]

We will miss you, Yuki! We wish you the best of luck, and it was a pleasure working with you in the lab!

[MacMillan Group @MacMillan_Lab]

Huge congrats to Will, Inji, and Eli on passing their generals exams! 🎉👏 Major milestone achieved—so proud of our grad students! 🧪✨

[MacMillan Group @MacMillan_Lab]

We’re hiring a postdoc in collaboration with J&J! The position will be split between our lab and J&J’s Spring House site. We’re looking for someone with a strong chemistry background ideally with expertise in photochemistry and developing photocatalysts.

https://t.co/3WCQlFbtLI

[MacMillan Group @MacMillan_Lab]

Our recent JACS paper unveils a metallaphotoredox platform enabling N-alkylation with alcohols, acids, or halides — even in complex drugs & peptides! Opening the door to new C(sp³)-rich drug designs. Congrats, Johannes, Danielle, and Aimee!

https://t.co/yV0hz4fOqe

[MacMillan Group @MacMillan_Lab]

Our latest μMap platform in action on @ChemRxiv! In collaboration with BMS we efficiently deconvolute MoAs from a large phenotypic screen, uncovering BACH2 degraders that act via upstream kinases & harness LONP1. A powerful example of rapid MoA resolution

https://t.co/f1chJ4w8Da

[MacMillan Group @MacMillan_Lab]

Old tissue, new tricks??
We introduce μMap-FFPE—a high-resolution protein photoproximity labeling platform for archived FFPE tissue. Check out this paper for your spatial proteomics needs and to learn more about CD20 in clinical tissue samples.

📃: https://t.co/zaOnjlXm7q

[Princeton Chemistry @PrincetonChem]

With thanks to these esteemed early-career researchers Steve, Sijbren, Alex, Kristina, and Erik who presented at yesterday’s Princeton Catalysis Initiative Symposium opener. Well done, all.

[Princeton Chemistry @PrincetonChem]

‘Tis the season! Here, Noah Bissonnette of the @MacMillan_Lab during his dissertation defense, and being introduced by adviser David MacMillan.

Best of luck to all graduate students defending this spring! You are our future.

[MacMillan Group @MacMillan_Lab]

Alcohols + aryl acids = C(sp3)–C(sp2) bonds! In collaboration with @LongLabCal & Merck Boston, we combine NHC-deoxygenation & Ni-catalyzed decarbonylation to link overlooked building blocks. Congrats Eva, Johnny, Edna, Stephanie, Kurtis, Cesar & Ryan!

https://t.co/RgfT2QXeRm

[Princeton Chemistry @PrincetonChem]

Thrilled to announce that Brandon Bloomer of the @MacMillan_Lab has been named a 2025 @BeckmanFnd Postdoctoral Fellow in the chemical sciences, one of just 14 across the country.

Congratulations, Brandon! Announcement here: https://t.co/VKl6JRulcz

[MacMillan Group @MacMillan_Lab]

Check out our newest work in Chem to achieve 3-functionalization of BCPs to access diverse aryl bioisosteres. Congrats Kat!

Give it a read here: https://t.co/qk4RdozgYW

[MacMillan Group @MacMillan_Lab]

Want to selectively couple two radicals?... You're in luck!

Check out our newest work in Nature where we use dynamic orbital selection to unlock alkylation of native aryl C–H bonds.

Congrats to @GrosskopfJo, Charlene, Robert, and Alex!

Read more at: https://t.co/6DoDJhVVk4

[Christopher Kelly @ckellzchem]

Spring into some great seminars from @POCC_Chem ! Next week's installment is @PrincetonChem very own @dmac68 for our Allan Day award lecture. Prof, MacMillan will be discussing research from @MacMillan_Lab including organocatalysis, photoredox catalysis, and microenvironment mapping. Join us on Thurs 3/27 at 6:30 PM for food/drinks with the talk kicking off at 7:30 at @PennChemistry !!!