Agnieszka Pierzyńska-Mach

Imaging Scientist at @LeBIOP @epflSV @EPFL.
Previously: @MSCActions fellow at @IITalk @DiasproLab.
Also: singing soprano, farming and cooking too much.

[Agnieszka Pierzyńska-Mach @MachPierzynska]

We discovered new nuclear bodies!✨🔬Our latest article in @J_Cell_Sci demonstrates how DEK's focal assemblies regularly occur at heterochromatin replication sites exclusively in the late S-phase! Great collaboration with @ferrandoelisa, @AD1959 & Ferdinand Kappes!
@IITalk
(1/4)

[Agnieszka Pierzyńska-Mach @MachPierzynska]

Happy Halloween! 🙃

[Elon Musk @elonmusk]

Good morning

[Vicidomini Lab @VicidominiLab]

PhD Opportunity in Advanced Microscopy. If you're passionate about building innovative instruments and thriving in a hands-on lab environment, join our lab @IITalk. DM for info. Please RT.
#PhDPosition #fluorescence #photonresolvedmicroscopy #STEM
https://t.co/vC5SoxSAt8

[Lorenzo Scipioni @LorenzoScipion3]

Finally home after and awesome (and intense!!) #FOM2024, it's been a blast to catch up with old friends (and new) in the city of my PhD! Looking forward to more meetings like this now that we'll be soon in the same continent! :D

[Agnieszka Pierzyńska-Mach @MachPierzynska]

The #FOM2024 just finished! Congratulations to the organisers @diasprolab for a fantastic conference! From captivating lectures to invaluable networking, it's been a great time for discussion and research inspiration.

[Single Molecule Localization Microscopy Symposium @SMLM_Symposium]

🔬✨ #SMLMS2024 update: thrilled to have the amazing @miCHRIScopy and @rita_strack joining us as invited speakers for the symposium. Stay tuned for more updates, we're working on a plan for the social evening that will be 😍. Don't miss out https://t.co/4K00Td1pzv

[Agnieszka Pierzyńska-Mach @MachPierzynska]

So excited to be back! Both in Genova and #FOM2024! Ready to soak up knowledge and connect with great scientists! 🔬✨

[Agnieszka Pierzyńska-Mach @MachPierzynska]

Good news indeed!✨

[European Research Council (ERC) @ERC_Research]

📣 Good news!

As negotiations between the 🇪🇺 EU and 🇨🇭 Switzerland have been officially launched today, researchers based in Switzerland can now once again apply for ERC grants.

Read more 👉 https://t.co/8mi6DAx9D0

[Ricardo Henriques @HenriquesLab]

Registration for #SMLMS2024 is now open! An amazing lineup of speakers and beautiful settings ☀️🌊🏄‍♀️🔬. Help us spread the word!

Looking forward to seeing you in Lisbon
https://t.co/liijebL5Wz

[Agnieszka Pierzyńska-Mach @MachPierzynska]

@NCN_PL @wieczorekdarek @MNiSW_GOV__PL bardzo dobra wiadomosc! 💪

[Agnieszka Pierzyńska-Mach @MachPierzynska]

Love is in the... cell ! ❤️🔬👩‍🔬
(Lamin A + actin + DNA)
#ValentinesDay

@IITalk
@DiasproLab

[Giorgio Tortarolo @GTortarolo]

🙌Yes !

Video research highlight for our recent work on #fluorescence #lifetime #imagescanningmicroscopy - with the SPAD array detector from @genoainstrument !

✨Grateful to @SPIEtweets for this !

@VicidominiLab @ZuninoAle @IITalk

https://t.co/z1Qax3ZfeM

[Agnieszka Pierzyńska-Mach @MachPierzynska]

What an impressive work done by @GTortarolo and @ZuninoAle at @VicidominiLab @IITalk ! ✨
Grateful and proud of playing a small role in this awesome paper about the fluorescence lifetime Image Scanning Microscopy with a SPAD array detector! 🔬

[Giorgio Tortarolo @GTortarolo]

✅ Fluorescence lifetime imaging
✅ Multicolour
✅ Super-resolution
... and everything all at once✨

(Almost) everything is possible with the SPAD Array Detector!

New paper from @ZuninoAle and me, with my friends at @VicidominiLab and @genoainstrument!

https://t.co/iyAgruyEqC

[Agnieszka Pierzyńska-Mach @MachPierzynska]

Excited to share I've joined BIOP at @EPFL as an Imaging Scientist! 🔬
Ready to tackle biological questions with the cutting-edge microscopy techniques! 👩‍🔬
Many thanks to @SeitzArne for this exciting career move and my mentor at @DiasproLab for all the growth opportunities. ✨

[Agnieszka Pierzyńska-Mach @MachPierzynska]

All hands on DEK! 🌟Our study on the formation of DEK bodies has been recognized with a Research Highlight in @J_Cell_Sci!
👏Big thanks to the amazing team at @IITalk, @UniKonstanz, @ferrandoelisa, @DiasproLab, @AD1959 and Ferdinand Kappes!
Check it out 👉 https://t.co/2mVM0ntbw1

[Agnieszka Pierzyńska-Mach @MachPierzynska]

Exciting news!✨@J_Cell_Sci featured me in their First-Person Interview, where I revealed my eureka moments, cherished mentors, and the motivation driving my scientific journey.🖊️Check the behind-the-scenes of my research! @IITalk @MSCActions
#imaging #epigenetics #nuclearbodies

[J Cell Science @J_Cell_Sci]

Read more about this research in our ‘First person’ interview with Agnieszka Pierzynska-Mach: https://t.co/rotwguXVcc

[J Cell Science @J_Cell_Sci]

@MachPierzynska @IITalk, Christina Czada, Ferdinand Kappes, @ferrandoelisa, et al. discover that DEK oncoprotein forms SUMO-dependent nuclear bodies at active sites of constitutive heterochromatin replication.
Highlight: https://t.co/5jFNJ3iHb3
Article: https://t.co/d7kDudKsyG

[Agnieszka Pierzyńska-Mach @MachPierzynska]

This work combines and refines our previous data on DEK as a factor essential for heterochromatin integrity and facilitating replication under stress and delineates an avenue of further study for unraveling the contribution of DEK to cancer development. Have a good reading! (4/4)

[Agnieszka Pierzyńska-Mach @MachPierzynska]

We discovered new nuclear bodies!✨🔬Our latest article in @J_Cell_Sci demonstrates how DEK's focal assemblies regularly occur at heterochromatin replication sites exclusively in the late S-phase! Great collaboration with @ferrandoelisa, @AD1959 & Ferdinand Kappes!
@IITalk
(1/4)

[Agnieszka Pierzyńska-Mach @MachPierzynska]

Based on our co-immunoprecipitation study, we established that DEK is a SUMO target and that SUMOylation is required to form DEK bodies. We propose that SUMO is a novel player in the network of DEK modifiers involved in regulating its function during DNA replication. (3/4)