Maerkl Lab

Synthetic Biology, Microfluidics and Diagnostics. Institute of Bioengineering - School of Engineering - Swiss Federal Institute of Technology @EPFL_en

[Maerkl Lab @MaerklLab]

Cells, who needs them? Fun to be in @nature.com’s technology feature with @MichaelCJewett , @thenoireauxlab, @HNiederho, Wilson Wong, @LucksLab, Evan Karousis, Yan Zhang, Emily Chen & @cynbio01 🧪
https://t.co/yJvdjfzi3l

[Maerkl Lab @MaerklLab]

We combined cell-free protein synthesis + microfluidics to rapidly map how SARS-CoV-2 mutations affect antibody binding — 518 RBD variants, ~31,700 affinity measurements, 3 binding-energy landscapes spanning WT to Omicron.

[Maerkl Lab @MaerklLab]

Jiami and Laura's paper is out now! In collaboration with the Reddy lab at ETHZ!

https://t.co/jLYQ7od3SF

[Maerkl Lab @MaerklLab]

Pao-Wan and co's paper is published now as well !

"A T7 RNAP regulatory toolbox for cell-free network engineering and biosensing applications"

https://t.co/HjZBeO4WLK

[Maerkl Lab @MaerklLab]

Saeed's paper is now published:

"PURE makes PURE: reconstitution of the PURE cell-free system from self-synthesized proteins"

https://t.co/5VtXKX5NGG

[Maerkl Lab @MaerklLab]

Maria's paper on characterizing trans-properties of transcription factors and how they affect gene expression is out now!

https://t.co/qszuyUOVk4

[Maerkl Lab @MaerklLab]

Saeed's latest paper is now out on bioRxiv:

"PURE makes PURE: reconstitution of the PURE cell-free system from self-synthesized non-ribosomal proteins"

https://t.co/tjP9axgprx

[Maerkl Lab @MaerklLab]

Check out Amogh's latest review:

"Microfluidics meets cell-free systems: from molecular engineering to synthetic cells"

now published in Current Opinion in Biotechnology.

https://t.co/MP1GSxQr8N

[Maerkl Lab @MaerklLab]

Laura and Jiami's paper is out now on BioRxiv! Nice collaboration with the Reddy lab at ETHZ:

"High-throughput cell-free profiling of SARS-CoV-2 RBD variants enables rapid and quantitative in vitro affinity landscape mapping."

https://t.co/s5HE3XOYGV

[Maerkl Lab @MaerklLab]

The Maerkl Lab is now on Bluesky (better late than never as they say...)!
https://t.co/S63wCkv8KP

[Maerkl Lab @MaerklLab]

Fanjun and Amogh's paper is now published:

"Continuous in situ synthesis of a complete set of tRNAs sustains steady-state translation in a recombinant cell-free system"

https://t.co/WGFCZiA2Vc

[Maerkl Lab @MaerklLab]

Pao-Wan, Saeed and Matthis' paper is out now on BioRxiv:

"A T7 RNAP regulatory toolbox for cell-free network engineering and biosensing applications"

https://t.co/f7MCiZM6o9

[Maerkl Lab @MaerklLab]

Fanjun and Amogh's paper is out now on BioRxiv:

"Continuous in situ synthesis of a complete set of tRNAs sustains steady-state translation in a recombinant cell-free system."

https://t.co/OnCGJCUOuf

[Maerkl Lab @MaerklLab]

Laura and Laura's paper is out now in ACS Synthetic Biology.

"Long-Term Protein Synthesis with PURE in a Mesoscale Dialysis System"

https://t.co/wfQhPvp4Zd

[Maerkl Lab @MaerklLab]

Pao-Wan's review on cell-free regulatory components is out now!

Regulatory Components for Bacterial Cell-Free Systems Engineering | ACS Synthetic Biology https://t.co/z4Z0N8X3JW

[Maerkl Lab @MaerklLab]

Laura (@SuNMIL_EPFL) and Laura's paper on running the PURE system for weeks using a simple mesoscale dialysis system is now on bioRxiv!!

"Long-term protein synthesis with PURE in a mesoscale dialysis system"
https://t.co/AOPM1wl68e

[Maerkl Lab @MaerklLab]

The Maerkl Lab is hiring one or two graduate students to work in the area of cell-free synthetic biology, specifically synthetic cell engineering! Deadline for our EDBB doctoral program is Nov 1st ...

See below for more information:
https://t.co/tWNJBzbzNJ

[Maerkl Lab @MaerklLab]

Ragu's paper is now officially out in ACS SynBio:

Towards Self-regeneration: Exploring the Limits of Protein Synthesis in the Protein Synthesis Using Recombinant Elements (PURE) Cell-free Transcription–Translation System | ACS Synthetic Biology https://t.co/GjO3M1WLAz

[Maerkl Lab @MaerklLab]

Laura's paper from the Stellacci lab (@frstella) is out now:
Nature-Inspired Recycling of a Protein Mixture into a Green Fluorescent Protein-based hydrogel - now published in RSC Sustainability
https://t.co/oLMxdY5tlE

[Maerkl Lab @MaerklLab]

Amogh's comprehensive review of microfluidic approaches and applications in cell-free synthetic biology is out now!

#microfluidics #cellfreesynbio #synbio #syntheticbiology

https://t.co/QQ3EMNJc6e