Rob Mani

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Mastering others is strength, mastering yourself makes you fearless.
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[Rob Mani @ManRam930]

$CLPT is the backbone of precision brain medicine. With field specialists in the OR & recurring revenue from every neurosurgical gene delivery, CLPT is the logistics layer for a neuro-intervention market about to explode. FDA-cleared therapies are rising & $CLPT owns the route 🚀

[Rob Mani @ManRam930]

$CLPT moving into Focused Ultrasound! $CLPT just entered into a 10-year partnership with Sungkyunkwan University in South Korea after a successful preclinical trial showing IV delivery of large-molecule tracers across the BBB using their prototype systems. Strong progress! 💪

[Rob Mani @ManRam930]

One of the biggest takeaways for me was capacity expansion. It has overlooked upside because the new $CLPT Advanced Laboratories facility is operating at just 20% utilization and hasn’t even taken over the full first floor of its three-story building. This shows the company is intentionally putting in place far more infrastructure than it needs for current volumes, positioning it for significant future growth.

[Rob Mani @ManRam930]

Strong Q1 2026 $CLPT results! Record $12.1M revenue (+43% YoY), 25% organic device growth, 175+ activated centers, Gross margin expanded 64%, FDA-cleared Velocity Alpha Drill now in use, Canadian approval, and first APAC commercial case. On track for $52–56M full-year guidance 🔥

[mike @mike98572986]

$qure $clpt

Let’s goooooooooo

[Rob Mani @ManRam930]

$CLPT Exciting regulatory progress for $QURE AMT-130! Successful UK MHRA pre-submission meeting clears path for MAA filing in Q3 2026 + FDA Type B meeting in Q2 2026. $CLPT's delivery platform powering UniQure’s AMT-130 for Huntington's disease patients. Hope on the horizon! 🚀

[Peter Mantas @peter_mantas]

I flew to Baltimore with a thesis and I left with something harder to quantify. This is by far the most important (and moving) piece I've written — on HD, on $QURE, and on what the FDA has done to people who deserve better.

Share if you can.

Link below.

[Rob Mani @ManRam930]

$CLPT scores fresh FDA clearance! The Velocity Alpha MR High Speed Surgical Drill is now cleared and already in clinical use. Paired with SmartFrame, it can cut multi-trajectory procedure times by an hour or more – further strengthening $CLPT's drug delivery ecosystem 🎯

[Rob Mani @ManRam930]

$CLPT delivering real hope in epilepsy! Neurona fresh updated data on NRTX-1001: 89% median disabling seizure reduction sustained long-term in unilateral MTLE, clean safety, & stable cognition across 31 patients. $CLPT's precision navigation powering regenerative cell therapy 🔥

[Rob Mani @ManRam930]

Huge milestone for $CLPT! Health Canada approved $CLPT's Neuro Navigation System (MRI + iCT). Combined with SmartFlow, this brings US-level workflow standardization to Canadian centers by cutting trial complexity, lowering variability, and accelerating cell & gene therapy development toward global scale and 20,000 procedures per year 🌎

[Rob Mani @ManRam930]

Today marks a major leap forward for $CLPT. UCB’s acquisition of Neurona brings serious firepower to multiple neural cell therapy programs in epilepsy and beyond. As development accelerates, $CLPT's proven delivery technology will be used more than ever to get these cells exactly where they need to go in the brain. The market is underestimating how foundational this is for $CLPT 🔥

[Rob Mani @ManRam930]

Massive win for $CLPT! UCB just acquired Neurona Therapeutics for up to $1.15B to accelerate regenerative cell therapy for drug-resistant epilepsy. Every dose of NRTX-1001 is delivered via $CLPT. This is the kind of validation that moves the needle hard. Full speed ahead 🚀

[mike @mike98572986]

$clpt

Neurona getting bought out = game changing moment, the 2 epilepsy programs are golden, and Alzheimer’s third program is going to get money thrown at it. Market is sleeping on what this truly means. One of the most important days in clearpoint history.

[Rob Mani @ManRam930]

Strong institutional signal for $CLPT! Hedge fund ownership hit all-time highs ending 2025: total shares held crossed 11M+ and the number of hedge fund holders also peaked at record levels. Clear acceleration from 2023-YTD shows smart money building conviction in the neuro ecosystem, IRRAS integration, and cell/gene therapy upside (despite short-term guidance noise). Very bullish setup! 📈

[Rob Mani @ManRam930]

Fair point on lowered guidance and no hard breakeven timeline - However, IRRAS integration (closed Nov '25) did drive higher op ex (+21% FY, including severance/professional fees), one-time liability paydowns (approx. $8M non-recurring), and Europe strategy reset, all of which tightened the near-term outlook. Things only looking up from here! Especially with IRRAS taking off. Remember, Q4 only saw approx. $1.2M partial IRRAS revenue (not full run-rate), so 2026 ramps that in meaningfully.

[Rob Mani @ManRam930]

$CLPT just delivered its STRONGEST quarter ever! Q4 2025 revenue +33% YoY to $10.4M, full-year $37M, gross margin 62%, and cash now $45.9M (+128% YoY). IRRAS is already contributing, all 4 growth pillars set for double-digit growth in 2026, 60+ biopharma partners, and 10+ in FDA fast-track. CEO set conservative 2026 guidance of $52–56M with ZERO meaningful revenue from FDA rare disease approvals (ex. $QURE) amid recent FDA hurdles. Any green light? Pure upside! 2026 is the launchpad for $CLPT with clear runway to $200M+ as the essential neuro ecosystem for cell & gene therapy 🚀

[Rob Mani @ManRam930]

@mike98572986 Well said!

[Rob Mani @ManRam930]

@TB2426638837 Great PM me!

[mike @mike98572986]

$clpt $qure

Justice has prevailed

Thank you Scientist Andrew, you will truly go down as one of greatest Americans of all time

We thank you for your service.

[Peter Mantas @peter_mantas]

My letter to the @SenateAging, @SenRickScott, @SenGillibrand on the FDA's recent FDA's handling of AMT-130 for Huntington's disease.

The same day the FDA called it a 'failed product', the UK Government officially called it a breakthrough.

The HD community deserves better.