Manna Lab

Cytoskeleton and Cell Division Laboratory @tvmiiser
Understanding Mammalian Cell Division: Centrosome Biology and Spindle-Kinetochore Attachment

[Manna Lab @MannaLab1]

I am delighted to share the exciting news of new publication from our lab https://t.co/iDiNob96u9 . Congratulations to @Swarnendu_1997, Qi Gao, and Prof. Dr Elmar Schiebel for this remarkable publication.

[Manna Lab @MannaLab1]

Excited to share our latest paper in @JBiolChem! 🌟 @anandushma et al. identify FBXW7 as a critical regulator of centriole duplication, degrading the Plk4-phosphorylated STIL-SAS6 complex.
Great effort by the whole team! 👏
https://t.co/UTyAv2mdt0

[Manna Lab @MannaLab1]

@msvichu2007 @bio_iisertvm @tvmiiser Thanks @msvichu2007

[Manna Lab @MannaLab1]

🎉 We’re delighted that our PI, Prof. Tapas Manna (School of Biology), has been elected as a **Fellow of the Indian National Science Academy (INSA), New Delhi!** 👏
Big congratulations to Prof. Manna on this achievement — and of course we celebrated with cake! 🎂✨

[Manna Lab @MannaLab1]

@Bhagya_Lakshmi_ @bio_iisertvm @tvmiiser Thanks @Bhagya_Lakshmi_

[Manna Lab @MannaLab1]

@NathSomsubhra @bio_iisertvm @tvmiiser Thank you @NathSomsubhra

[Manna Lab @MannaLab1]

@poonam_thakur6 @Pradip_Pb21 @bio_iisertvm @tvmiiser Thank you @poonam_thakur6

[Shweta Tyagi @ShwetaTyagiCDFD]

Very excited to welcome and hear from the esteemed speakers in 'Microtubule Network' meeting at CDFD 🎉 🎉 with @GunjanM43894285

#microtubules #centromeres
#centrosome #mitosis
@DBT_CDFD @KaustuvSanyal @vmdraviam @Sachin_mitosis @almut_kelber @c_swadhin @MannaLab1 @PS_lab

[Manna Lab @MannaLab1]

Prof. Tapas K. Manna and PhD student Swarnendu Mukhopadhyay presented their research at the Indo-German Meeting on Cytoskeleton Biology in Health and Diseases held at IISc (June 3–5, 2025).
Their talks highlighted new insights into centriole duplication and biogenesis.
#MannaLab

[Sandhya Koushika @WormlockHolmes]

Aneuploidy induction mechanisms via the CENP-E kinesin, a chromosome transporter, that is associated with cancer. CENP-E also reqd to maintain interpolar microtubules. Tapas Manna @tvmiiser in #M2T22025

[Manna Lab @MannaLab1]

Excited to share that @Swarnendu_1997 and @Delvinpauly won the Best Poster Prizes at the FS-Bio Symposium held at IISER Thiruvananthapuram from Feb 7-9!

[School of Biology, IISER-Thiruvananthapuram @bio_iisertvm]

Congratulations to the winners of the best poster prize: Delvin, Swarnendu, Hritik, Jeena, Special mention posters: Santosh, Tiyas, and Parnika. Best Flash Talks: Anandita and Kavitha.

[Manna Lab @MannaLab1]

Ushma Anand presented her research at ASCB EMBO Cell Bio 2024 (Dec 14-18, San Diego), supported by an EMBO travel grant. Her poster and teaser talk in the “Everything Microtubules & Cell Division” session highlighted FBXW7’s role in regulating STIL and centriole duplication.

[Manna Lab @MannaLab1]

Manna lab, during the poster session at 6th International Chromosome Stability meeting, JNCASR, Bengaluru, India

[Manna Lab @MannaLab1]

Had an amazing time celebrating Onam in the lab yesterday! 🌸🌿 The vibrant Pookalam, delicious sadya, and great company made it unforgettable. #Onam2024 #LabCelebrations #FestiveVibes #CCD

[Manna Lab @MannaLab1]

It's the end of another academic year! 🥂 Cheers to @Bhagya_Lakshmi_, @LiasusanGeorge, @ShebaCheeran, and @msvichu2007 on graduating! 🎓 Your contributions to the lab was invaluable. Best wishes for your future endeavors! 🎉🌟

[Manna Lab @MannaLab1]

A huge congratulations to Dr. Bhagya Lakshmi @Bhagya_Lakshmi_ for successfully defending her PhD thesis! 🎉 It was great to have her amidst us doing cool science. Wishing her all the best as she steps into an exciting new chapter at @barisic_lab 🌟

[Manna Lab @MannaLab1]

👏🎉 Congratulations Dr Vishnu M Nair on successfully defending your thesis on the role of E3 ubiquitin ligase, FBXW7, in mitotic checkpoint regulation! It was a truly great Journey throughout. #TKMLab

[Manna Lab @MannaLab1]

1/4 kinetochores which in turn ensures optimum dynein mediated stripping of CENP-E thus leading to its stabilization at the aligned kinetochores.

[Manna Lab @MannaLab1]

Kudos to @Bhagya_Lakshmi_ , all the authors and thanks to collaborators @BenDavidLab, Dr. Raja Paul, Dr. Sarit Agasti for the work published in EMBO reports. The paper sheds light on the crucial role of CKAP5 in stabilizing CENPE at the kinetochore. https://t.co/aC17996g3w

[Manna Lab @MannaLab1]

Co-depletion of dynein adaptor Spindly along with CKAP5 showed a significant rescue in kinetochore levels of CENP-E. Altogether, our results suggest a mechanism by which CKAP5 regulates stability of kinetochore attached microtubules and maintains optimum PP1 levels at the.....

[Manna Lab @MannaLab1]

CKAP5 depletion leads to increased stability of kinetochore attached microtubules and an associated increase in recruitment of protein phosphatase 1 (PP1) to the kinetochores.