Manuel Leonardo Merz

Postdoctoral Fellow in #ChemicalBiology @ChoudharyLab @broadinstitute | 🇨🇭 based in 🇺🇸

[Manuel Leonardo Merz @ManuelLMerz]

Hot off the press 🔥

In our paper published today in @nchembio, we tackled the challenge of developing orally bioavailable peptides💊

➡️You can read the full article here (open access🔓): https://t.co/8XX5mGK8fA

A brief 🧵

1/5

[Alexander L. Nielsen @alexanderln91]

Very pleased to share one of my postdoctoral works from the Heinis lab. Now published in @angew_chem #openaccess #macrocycles
https://t.co/9Doa451TdA

[Manuel Leonardo Merz @ManuelLMerz]

🌟 Excited to share some thrilling news! 🌟

I'll be speaking at the upcoming Next Gen Peptide Formulation & Delivery Summit, where I'll be talking about our efforts in developing orally bioavailable cyclic peptides.💡

Follow this link to find out more: https://t.co/CONxpiBTnx🚀

[Alexander L. Nielsen @alexanderln91]

Latest paper from the Heinis lab.
Solid-phase peptide synthesis in 4 × 384 well-plates to prepare 1,536 peptides per run! Out in J. Pept. Sci!
Big congrats to co-first authors Mischa and @EdJWill!
@EPFL_CHEM_Tweet
https://t.co/8Zrkpb1eMV

[Manuel Leonardo Merz @ManuelLMerz]

Last but not least:

A short research briefing can be found here: https://t.co/x003dMkinV

5/5

Thanks for staying until the end 👋

[Manuel Leonardo Merz @ManuelLMerz]

What's next❓

We hope to apply this strategy to other disease targets in the future and to further unlock the therapeutic potential of peptides. 🔓💊

4/5

[Manuel Leonardo Merz @ManuelLMerz]

What did we do❓

We developed a method for generating cyclic peptide libraries & identified potent, selective inhibitors that are orally bioavailable in rats.

Most importantly, we were able to improve affinity and membrane permeability simultaneously in functional screens.

3/5

[Manuel Leonardo Merz @ManuelLMerz]

Hot off the press 🔥

In our paper published today in @nchembio, we tackled the challenge of developing orally bioavailable peptides💊

➡️You can read the full article here (open access🔓): https://t.co/8XX5mGK8fA

A brief 🧵

1/5

[Manuel Leonardo Merz @ManuelLMerz]

First of all:

Huge thanks to everyone from the #HeinisLab & @EPFL_en / @EPFL_CHEM_Tweet involved in this project for the great collaboration (@BoLi_Pep, @alexanderln91 & many others)

2/5

[Kaycie Butler | SciComm tips 📝 @ButlerKaycie]

How to successfully write a grant proposal.

I have worked on >50 grants over the last few years and host workshops about how to write your own.

These are my master tips.

A 🧵

@openacademics
@YTacademics

#scicomm #Academittwitter #academicchatter
1/4

[Kaycie Butler | SciComm tips 📝 @ButlerKaycie]

🧵A thread to set your GRANT WRITING MINDSET!
I review >10 GRANT PROPOSALS/yr, and find consistent mistakes that can be fixed with a quick MINDSET shift:
How to think about a proposal
Who reviews it
The review process
@OpenAcademics @PhD_Balance @PhDfriendSana
#Academicchatter

[Ariel Furst @afurst1]

So excited to share the first work entirely from our group! Congrats @FurstLab @rariella1 @ReynoldsErinE Thanks @ACSCentSci @CarolynBertozzi @christhechang!
https://t.co/GX2QYMyUoZ

[Manuel Leonardo Merz @ManuelLMerz]

How many of those have you written? 😅📝 @ButlerKaycie

[Manuel Leonardo Merz @ManuelLMerz]

Can highly recommend this program!

[SNE ChemBio @SNE_ChemBio]

Why choose the Master in Chemical Biology @unige_en?
What are the career prospects?
Why study in Geneva 🇨🇭?
How is the degree structured?

Prof. Loewith gives answers to these questions!

📽️Watch the video:
https://t.co/YpnxhlY2PL

#studyabroad #studyinswitzerland #unige

[Manuel Leonardo Merz @ManuelLMerz]

@KatharinaJungo congrats 🎉

[Harvard Microbial Sciences Initiative (MSI) @HarvardMSI]

For a great explanation of MFCs and a deeper look into some of the work one optimizing this technology, check out this talk from the annual MSI symposium by Dr. Ariel Furst @afurst1

https://t.co/p9Je7c5Wwu

[FurstLab @FurstLab]

First paper from the Furst Lab published today in ACS infectious diseases! Congrats Amruta and Ariel! https://t.co/ePFDxj0lY4