Maria C. Cuellar-Gutierrez

Reumatóloga
Hospital del Salvador, Santiago, Chile

[Mayo Clinic Nephrology @MayoClinicNeph]

Evaluating Chronicity Scores for Outcomes in Patients With Lupus Nephritis

@KIReports @SethiRenalPath

https://t.co/QbLtKp2srN

[Alí Duarte, MD @AliDuarteMD]

Grateful to the legendary Sanjeev Sethi for partnering with our team.

[Alí Duarte, MD @AliDuarteMD]

Bottom line: MCCS and NIH-CI are comparable and add prognostic signal beyond clinical data—with IF/TA doing most of the heavy lifting—and performance was consistent in Class V LN. MCCS may offer a practical edge by aligning chronicity grading across glomerular diseases.

[Alí Duarte, MD @AliDuarteMD]

In lupus nephritis (LN), “activity” gets the spotlight—but chronic scarring often decides the long game. So: which chronicity score best predicts outcomes—NIH Chronicity Index (NIH-CI) or the Mayo Clinic Chronicity Score (MCCS)?
https://t.co/eyt9txJqQr

[Maria C. Cuellar-Gutierrez @MariaCuellarMD]

Why should it replace the current NIH chronicity score?

- It is universal, tested in other glomerulopathies, not just lupus nephritis.
- It includes chronic damage to the vascular compartment (not just the glomerulus, interstitium, and tubules). Namely, arteriosclerosis.

[Sanjeev Sethi @SethiRenalPath]

I scored > 300 lupus nephritis biopsies for chronicity indices with Maria Gutierrez/Chile.

Bx scoring was simple: minimal, mild, moderate, severe.

The chronicity score correlates very well with outcomes/prognosis.

Score should be included in Bx report.

https://t.co/IIC763OFOn

[Maria C. Cuellar-Gutierrez @MariaCuellarMD]

It was a pleasure working with you, Dr. Sethi.
And yes, it is definitely a score that should be used in lupus nephritis biopsy reports.

[Sanjeev Sethi @SethiRenalPath]

I scored > 300 lupus nephritis biopsies for chronicity indices with Maria Gutierrez/Chile.

Bx scoring was simple: minimal, mild, moderate, severe.

The chronicity score correlates very well with outcomes/prognosis.

Score should be included in Bx report.

https://t.co/IIC763OFOn

[Sanjeev Sethi @SethiRenalPath]

I scored > 300 lupus nephritis biopsies for chronicity indices with Maria Gutierrez/Chile.

Bx scoring was simple: minimal, mild, moderate, severe.

The chronicity score correlates very well with outcomes/prognosis.

Score should be included in Bx report.

https://t.co/IIC763OFOn

[Zhivana Boyadzhieva @ZhivanaB]

In 2020 Beck et al. described the #VEXAS syndrome.

✨We are now excited to share our latest paper - a first systematic review of the literature on treatment strategies for VEXAS published in @RheumJnl📚

https://t.co/nV8ydsRaWC