Marqusee Lab

The Marqusee Lab @UCBerkeley uses #biophysics to study #proteinfolding in basic and cellular contexts. Account is student/postdoc run. All tweets in kcal/mol.

[Marqusee Lab @MarquseeLab]

Check out Naomi's paper examining domain coupling in mGlu receptors on bioRxiv! A fun collaboration with the @IsacoffLab and also featuring great work from our undergraduate researcher Sam! https://t.co/XFFMuKFP6J

[Marqusee Lab @MarquseeLab]

Check it out and let us know what you think! We are really excited by the combination of HDX-MS with eVLPs as it provides an opportunity to more easily study viral fusion proteins and other membrane proteins in native-like environments with HDX-MS.
7/7

[Marqusee Lab @MarquseeLab]

Check out Sophie's new preprint on bioRxiv in collaboration with Magnus Hoffmann's lab where we conduct HDX-MS on SARS-CoV-2 spike proteins displayed on eVLPs to understand the dynamics of natural and engineered variants. 1/7 https://t.co/L40Iswgwbm

[Marqusee Lab @MarquseeLab]

D614G shifts the equilibrium to favor the prefusion conformation while the S2' site stays disordered. This study provides, to our knowledge, the first molecular explanation for the dual evolutionary advantages of furin cleavage and D614G.
6/7

[Antoine Koehl @antoinekoehl]

Super cool work by twitterless Naomi and crew looking at domain coupling in mGlu receptors. @MarquseeLab @IsacoffLab

Domain coupling in activation of a family C GPCR https://t.co/wGRh3OjX2j

[Kresten Lindorff-Larsen @LindorffLarsen]

Big congratulations to PhD student Thea K Schulze from our PRISM centre on being awarded the elite research travel grant by the Minister for Higher Education and Science, Christina Egelund, to support a stay in the @MarquseeLab at Berkeley to study protein variant effects 💪🧬💻

[Marqusee Lab @MarquseeLab]

.@NRDall's paper is up on bioRxiv! Using high-throughput in vivo studies and biophysical in vitro assays (CD and HDX/MS), we show how circular permutation affects the expression of HaloTag in different cell environments, and how CP impacts protein stability and folding pathways

[bioRxiv Biophysics @biorxiv_biophys]

The importance of the location of the N-terminus in successful protein folding in vivo and in vitro https://t.co/Fr9YM6n9op #biorxiv_biophys

[Rosalie Lawrence @ScienceyRosalie]

It’s out! Via hydrogen deuterium exchange, biochemistry, and cryo-EM, we (Walter lab, @MarquseeLab et al) discovered the allosteric mechanism controlling activity of the core Integrated Stress Response (ISR) regulator eIF2B. 1/10 https://t.co/WFG1uDKXX6

[Evan O’Brien @evan_s_obrien]

Happy to be a part of such a cool story! Structural & dynamic characterization of mGluR intermediate states. Congratulations to Kaavya, @haoqing_wang and all authors. Another productive collaboration with @IsacoffLab & @MarquseeLab!

[Marqusee Lab @MarquseeLab]

Amir will present his work on cotranslational folding of the SARS CoV-2 RBD at poster board 15AB. Check out his abstract (#328) and give him a visit!

[Marqusee Lab @MarquseeLab]

Susan and @amir_bitran are in Boston for the Protein Society! Catch Susan's plenary talk on Thursday morning, and check out Amir's poster on Saturday evening.

[Marqusee Lab @MarquseeLab]

This was a fun collaboration with Mike Harms, @MattSternke, and @superdougb

[Marqusee Lab @MarquseeLab]

See Charlotte's new manuscript on bioRxiv

[bioRxiv Biophysics @biorxiv_biophys]

The importance of input sequence set to consensus-derived proteins and their relationship to reconstructed ancestral proteins https://t.co/BQsNBBjqrY #biorxiv_biophys

[Marqusee Lab @MarquseeLab]

Congratulations to our grad student Darren Kahan on being awarded the @advlightsource Doctoral Fellowship in Residence! He will be working with Dr. Corie Ralston’s lab at the @molecularfndry

[bioRxiv Biophysics @biorxiv_biophys]

Secondary Structure Detection Through Direct Nanopore RNA Sequencing https://t.co/2XNklSUVBS #biorxiv_biophys

[UC Berkeley @UCBerkeley]

Chemist Susan Marqusee takes leading role at National Science Foundation

https://t.co/U0hatekRKn