Mathieu Lupien

Senior scientist @Princess Margaret Cancer Centre, Prof @UofT. BHAG: Conquer cancer by treating it as a disease of the chromatin. Also on Bluesky

[Mathieu Lupien @MatLupien]

Upcoming cancer epigenetics conference in Paris (Oct 13-16, 2026). Consider registering: https://t.co/VyyIVSrJEA

[Mathieu Lupien @MatLupien]

Excited to share our @natgenet.nature.com study showing that epigenetically rewired transposable elements control AML leukemia stem cell properties and patient outcome.

Grateful to the team & collaborators. https://t.co/3XO9vlbLUT

[Mathieu Lupien @MatLupien]

Excited to share our Nature Genetics Research Briefing on how the repetitive genome helps shape leukemia stemness.
We found that transposable elements sustain stem-like states in AML and predict patient outcomes.
https://t.co/VneAltovj1

[Mathieu Lupien @MatLupien]

Excited to share our Nature Genetics Research Briefing on how the repetitive genome helps shape leukemia stemness.
We found that transposable elements sustain stem-like states in AML and predict patient outcomes.
https://t.co/VneAltovj1

[Mathieu Lupien @MatLupien]

Excited to share our @natgenet.nature.com study showing that epigenetically rewired transposable elements control AML leukemia stem cell properties and patient outcome.

Grateful to the team & collaborators. https://t.co/3XO9vlbLUT

[Princess Margaret Cancer Centre Research @PMResearch_UHN]

Our new study found that ancient DNA sequences in our genome, called transposable elements, can act as control hubs for leukemia stem cells, fueling therapy resistance and relapse in AML.
Led by @MatLupien & John Dick @UHN @pmcancercentre.
@NatureGenetics: https://t.co/4UAlmJqIl1

[Princess Margaret Cancer Centre Research @PMResearch_UHN]

New study introduces MOLEA, an AI platform that designs lipid nanoparticles for precision RNA delivery and therapeutic gene editing. @NatureBiotech #RNAtherapeutics

Read more: https://t.co/t58kcajqB0

[Mark Carney @MarkJCarney]

The first astronaut in history to speak French while en route to the moon — Canada’s very own @astro_jeremy 🇨🇦

[Denis Wirtz @deniswirtz]

Federal funding for US biomedical research is moribund.

Since October 1 2025, NIH is -80% in new grants and -70% in values (total dollars).

Labs are closing down and researchers are leaving science.

To what end?

[Mathieu Lupien @MatLupien]

Pleased to share our new @NatureCancer paper: We harmonized cfMeDIP-seq across 11 cancer types, integrating methylation & fragmentation to boost detection. https://t.co/BK2TRUs8co

[Nature Cancer @NatureCancer]

🌟New Resource article

Read about the pancancer landscape of cancer-specific cell-free DNA methylation and fragmentomic features from plasma samples from 1,294 patients

✒️Yong Zeng, @MatLupien, @PughLab, Housheng Hansen He & colleagues

https://t.co/niJ57sU9N2

[Princess Margaret Cancer Centre Research @PMResearch_UHN]

Researchers @UHN @pmcancercentre analyzed 1,294 blood samples from 11 cancer types to build a comprehensive atlas of DNA methylation patterns, advancing pan-cancer detection and monitoring using liquid biopsy: https://t.co/Zyz50tJ5Ra
@UHN_Research @MatLupien @hansenhe7 @PughLab

[Mathieu Lupien @MatLupien]

Massive team-science effort across @PMCancerCentre/@UHN, @UofT, @OICR and collaborators (incl. @TrevorPugh & Hansen He labs; lead author Yong Zeng). https://t.co/BK2TRUs8co

[Mathieu Lupien @MatLupien]

Pleased to share our new @NatureCancer paper: We harmonized cfMeDIP-seq across 11 cancer types, integrating methylation & fragmentation to boost detection. https://t.co/BK2TRUs8co

[Mathieu Lupien @MatLupien]

This resource strengthens the foundation for liquid biopsy monitoring to enable better, earlier, less invasive care. https://t.co/BK2TRUs8co

[Kira Furlano @KiraKornienko1]

Proud to share our newest publication, made possible by an exceptional and highly collaborative team @MatLupien @tina_kesha

https://t.co/uYGbTmkTu5

[Kira Furlano @KiraKornienko1]

Our new study found that, when prostate cancer cells spread, they adopt an “inflammatory-like” state and mimic immune cells, suggesting new ways to control cancer progression.
Co-led by @MatLupien @UHN @pmcancercentre with @DKFZ:

https://t.co/uYGbTmkTu5

[Princess Margaret Cancer Centre Research @PMResearch_UHN]

Our new study found that, when prostate cancer cells spread, they adopt an “inflammatory-like” state and mimic immune cells, suggesting new ways to control cancer progression.
Co-led by @MatLupien @UHN @pmcancercentre with @DKFZ:
https://t.co/lcHTyeCCHx

[Mathieu Lupien @MatLupien]

A jewel of a presentation on the history of chromatin. Always a pleasure to go back in time with those who helped shape it. I am grateful for the insights and stories shared by Drs. Ada and Donald Olins.
https://t.co/d92wjrljRs

[Mathieu Lupien @MatLupien]

Less than a month to go until the GRC on Hormone-Dependent Cancers! Looking forward to reconnecting with the community and sharing our latest on epigenomics of ecDNAs in tumor evolution. Hope to see you then. https://t.co/V70ymVsL7r