Jim Carrey's profound reminder:
"We get up, open our eyes, and the show begins... But a couple times a day, stop & go: This is just as real as those thoughts. I am bigger than these thoughts. I am bigger than this body."
"Every cell is God. When you do good, you are the heart of God. Baking bread? That's a Eucharist."
1:24 clip — beautiful perspective shift
When do you pause & remember you're bigger than the story?
Inflation means your bills got promoted and you didn’t.
The landlord got a raise.
The grocery store got a raise.
You got a “be grateful you have a job.”
Toys "R" Us and Chuck E. Cheese were both bought by private equity, sold for parts, and bankrupted. The reason why the country you grew up in no longer exists is unfettered greed by the ultra wealthy
I need every European, Canadian, & Australian think piece on “Do Americans uNdERsTanD…” to KEEP THAT SHIT IN THE DRAFTS.
There are more guns than people in this country.
Our police and military regularly and with impunity, fire on civilians.
Let’s stop glorifying burnt-out, and dysregulated nervous systems, and instead start promoting balance and rest without calling people lazy. XO, Dr. Jen
A new shot literally regrows knee cartilage.
Researchers at Stanford Medicine have identified a novel strategy to regenerate articular cartilage in knees and potentially prevent or treat osteoarthritis (OA).
The method targets 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an age-related enzyme—or "gerozyme"—that accumulates in aging tissues and drives degeneration.
In aged mice, small-molecule inhibitors of 15-PGDH, delivered systemically or via intra-articular injection, promoted cartilage thickening and regeneration of functional hyaline articular cartilage.
This occurred without recruiting stem or progenitor cells; instead, existing chondrocytes underwent transcriptional reprogramming to a youthful state, with reduced populations of inflammatory and hypertrophic/degradative cells and expanded matrix-producing articular chondrocytes.
The inhibitors also reversed natural age-related cartilage thinning, improved joint function, and—when administered after simulated ACL injuries—strongly mitigated post-traumatic OA progression and associated pain.
Human OA cartilage explants from total knee replacements responded similarly in vitro, showing decreased degradation markers and evidence of new articular cartilage formation.
Given that an oral 15-PGDH inhibitor has already completed Phase 1 safety trials for age-related muscle atrophy, the findings open a path toward disease-modifying, regenerative therapies that could delay or obviate the need for joint replacement surgery.
[Agarwal, P., Su, S., Ancel, S., et al. (2025). Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration. Science. DOI: 10.1126/science.adx6649]
Penei Sewell: "This year alone, it wasn't my best ball. It was far from that."
"It starts with me up front. I believe that I'm gonna set the tone. I'm gonna make plays that typically, o-linemen don't make... Going into the offseason, that'll be on my mind," the Lions tackle said.
Penei Sewell: "This year alone, it wasn't my best ball. It was far from that."
"It starts with me up front. I believe that I'm gonna set the tone. I'm gonna make plays that typically, o-linemen don't make... Going into the offseason, that'll be on my mind," the Lions tackle said.
Dr. Gabor Maté reframes ADHD with profound compassion:
In stressed families, a highly sensitive child absorbs the tension → tunes out as a survival coping mechanism.
These kids often have deep empathy, warm hearts, and hidden talents — but crave emotional security above all.
Not "fix the behavior" — make them feel truly safe and understood.
48-sec clip hits the heart
Parents/anyone touched by ADHD — does this resonate?
Tate Ratledge’s 80.1 PFF pass-block grade since Week 14 ranks eighth among all offensive guards.
Over that span, his 70.3 overall PFF grade ranks 19th out of 79 guards.