Matt Margolis

Data Scientist at Guardant Health. Opinions are my own

[Matt Margolis @Matt_Margolis]

@Alan_Couzens Mammography has a PPV of ~5%. Newer blood based cancer sceeening tests have a PPV of ~50% and the entire benefit risk calculation changes.

[Matt Margolis @Matt_Margolis]

@RoupenMD where can you post your own API key? Wasn't able to find that, and ran into a 400 error

[Matt Margolis @Matt_Margolis]

@GIMedOnc @realbowtiedoc @ShaalanBeg @ShrutiPatelMD @cancerassassin1 Where do I sign up

[Matt Margolis @Matt_Margolis]

@sachsubra @OpenAI @SweetspotGov any way to include access to free (and old!) govt databases (SEER*stat mainly) as a free service?

[JCO Precision Oncology @JCOPO_ASCO]

Prognostic Significance of Blood-Based Multicancer Detection in Circulating Tumor DNA: Five-Year Outcomes Analysis.

Read the full article. https://t.co/IpFjtrLnlD
#MedEd

[Matt Margolis @Matt_Margolis]

@andrewwhite01 Awesome to hear! I'm actualy unable to load the analysis. I get several errors that pop up. Regardless, awesome to hear, and even better for patients.

[Matt Margolis @Matt_Margolis]

@AartGoossens Would love this

[GRAIL @GrailBio]

Five-year CCGA3 outcomes in @JCOPO_ASCO show that cancers with a cancer signal detected result using a blood-based multi-cancer early detection (#MCED) test had survival consistent with matched SEER populations, including early-stage disease.

The MCED test was likely to find clinically significant cancers without contributing to overdiagnosis.

Read the abstract: https://t.co/G2AoPSnsEa

The Galleri test does not detect a signal for all cancers, and false positive and false negative results can occur. Diagnostic testing is needed to confirm cancer.

[Matt Margolis @Matt_Margolis]

@GIMedOnc We should look at both NHS-G and PATHFINDER2 as studies that are going to shape how screening paradigms change in the US and what clinical utility it has. Overall, screening (at this moment) is limited by biology, not technology - as we already have the technology in MRD setting.

[Matt Margolis @Matt_Margolis]

@GIMedOnc Trials like NHS-G take years to run and the science changes over that time period. We also don't know how COVID played a factor, especially in the NHS and their referral system.

[Matt Margolis @Matt_Margolis]

Our 5-year outcomes analysis of blood-based multicancer early detection is out in @JCO_PrecOnc.

Key takeaway: MCED test finds clinically significant cancers without contributing to overdiagnosis.

https://t.co/WdJsTZwqfh

[Matt Margolis @Matt_Margolis]

@cwhogg Made 2 MCPs for NHANES and BRFSS that may be of interest:
https://t.co/Fw0kQE0UDM

[Matt Margolis @Matt_Margolis]

Just shipped nhanes-mcp, an MCP server that gives
@ClaudeAI direct access to NHANES public health
data.

Open source below:
https://t.co/HdDvax3C4M

#PublicHealth #DataScience #AI

[Matt Margolis @Matt_Margolis]

@andrewwhite01 @andrewwhite01 would be great to see if Kosmos could recreate and confirm our hypothesis in our paper, identifying a nonvel subgroup of adenoid cystic carcinoma for potential targeted treatment.

https://t.co/dP88BaaYof

[Matt Margolis @Matt_Margolis]

@GIMedOnc Would love to chat more

[Matt Margolis @Matt_Margolis]

@j_g_allen How often do you recommend cleaning them? Or not using altogether?

[Matt Margolis @Matt_Margolis]

@doctorinigo @BarbaDelCid We’re all kras mutations identical in all mice? Presumably there would be different responses depending on mechanism? Eg: g12 vs q61

[Matt Margolis @Matt_Margolis]

@Brady_H @Ketoneiq Hey @Brady_H do you normally take ketones immediately after a long session and then carbs+protein? curious if that would negate the effect of the ketones

[Matt Margolis @Matt_Margolis]

@EdisonSci this is super impressive! Great work and exemplifies the core principle of reproducibility in science!

I am curiuos why you think some of the N don't match up exactly on the prevalence bar graph?