ALEX TAVARTKILADZE

Alexandre TAVARTKILADZE., Medical Oncologist, Professor of Tbilisi State Medical University, Medical Director of Institute for Personalized Medicine of Georgia

[ALEX TAVARTKILADZE @McalexandreGE]

A question that has occupied much of our scientific life:

Where does a metastatic cell become metastatic?

After 7 years of work, 614 participants, and analysis across 21 solid tumor types, we propose that the answer may lie within the central lymphatic system.

The cisterna chyli contained 12–15× more circulating tumor cells than blood and was enriched for EMT, stemness, proliferation, and invasion programs.

Not proof.

Not a conclusion.

But perhaps the beginning of a new way of thinking about metastasis.

Now in pre-review at Translational Oncology.

#Metastasis #CancerResearch #LiquidBiopsy #PrecisionMedicine #Oncology

https://t.co/6uP7rd55yM

[ALEX TAVARTKILADZE @McalexandreGE]

Can circadian biology influence treatment response in metastatic prostate cancer?

In our newly published case series, all patients demonstrated AR-V7 clearance, while an exceptional responder achieved:

✓ 96% PSA reduction
✓ Complete inflammatory biomarker normalization
✓ Restoration of nocturnal melatonin rhythm
✓ >30% radiographic regression
#ProstateCancer #Melatonin #Chronotherapy #Oncology

https://t.co/zLiV7IKgSV

[ALEX TAVARTKILADZE @McalexandreGE]

What if aging is not only about time?

Our study found that loss of nocturnal melatonin signaling converges with microbiome disruption, urolithin A deficiency, and brain clearance abnormalities.

Introducing the Microbiome–Glymphatic–Melatonin (MGM) axis.

#Aging #Melatonin #Microbiome #BrainHealth #Longevity

https://t.co/54MrCKkOe5

[ALEX TAVARTKILADZE @McalexandreGE]

Presented at #ASCO2026

In a 3-year cohort of 171 breast cancer patients, we found subtype-specific melatonin receptor expression on CTCs, linked with inflammatory and metabolic biomarkers.

#BreastCancer #LiquidBiopsy #CancerMetabolism

https://t.co/DMCs4UbQrQ

[ALEX TAVARTKILADZE @McalexandreGE]

Presented at #ASCO2026
Advanced lung adenocarcinoma demonstrated a shift from oxidative flexibility to glycolytic entrapment in a cohort of 150 treatment-naïve patients.

#LungCancer #CancerMetabo

https://t.co/kEQlmmeInI

[ALEX TAVARTKILADZE @McalexandreGE]

What if arrhythmias, epilepsy, cancer and cognitive decline share the same gut–melatonin disruption? Our 577-patient study says they do—and we found melatonin receptors on bacteria for the first time. Read it in @ABORSI_IJMS https://t.co/3GsS5YMrUp

[ALEX TAVARTKILADZE @McalexandreGE]

🧬 Our latest study explores the melatonin-microbiome axis and its impact on cognition and immune health. This axis reveals insights into the biochemical and pharmacological pathways affecting learning and memory.🌱 #Neuroscience #Microbiome #Melatonin
https://t.co/OdpSQtMTCT

[ALEX TAVARTKILADZE @McalexandreGE]

📢 New findings on AminoSineTriComplex show promise in fighting cancer! A breakthrough in cancer therapy! 💪 #Cancer #Oncology
https://t.co/PiCyT34Xrx

[ALEX TAVARTKILADZE @McalexandreGE]

My research is available on @ResearchGate: https://t.co/X5HErXU0bi

[Michelle Monje 🟦 @michelle_monje]

More bread therapy 🥖

[The New York Times @nytimes]

The job of pharmacy benefit managers is to reduce drug costs. Instead, they steer patients toward pricier drugs, charge steep markups on what would otherwise be inexpensive medicines and extract billions in hidden fees, The New York Times found. https://t.co/cqsX8IBiSl

[ALEX TAVARTKILADZE @McalexandreGE]

🕰️ Chronotherapy: A Game-Changer in Hodgkin’s Lymphoma Treatment! 🌟

chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://t.co/sv4l2OMZ5T

[Paolo Tarantino @PTarantinoMD]

Both @Annals_Oncology and @ESMO_Open confirm their prestige and high scientific impact. Consider submitting your science to the journals of ESMO! @myESMO

[ESMO - Eur. Oncology @myESMO]

ESMO journals have maintained strong IFs this year: @Annals_Oncology has attained its highest IF to date: 56.7.
The IF for @ESMO_Open is 7.1. ESMO continues to deliver high-quality medical science to the oncology community.
📌https://t.co/XMiKNhgan6

[Cardio Arena @CadioArena]

If you drink warm water lemon 🍋 and ginger, every morning this is what will happen to your body....

[ALEX TAVARTKILADZE @McalexandreGE]

#NewProfilePic

[ALEX TAVARTKILADZE @McalexandreGE]

Melatonin in Cancer Control

https://t.co/Pp0nSAXhbW

[𝗡𝗶𝗵𝗮𝗿 𝗗𝗲𝘀𝗮𝗶 MD, DM @nihardesai7]

30/♂️/ with right cervical lymphadenopathy!!

Excision biopsy 👇🏼 Time for some 🍿

Diagnosis?
Management?

#MedTwitter

[Cardio Arena @CadioArena]

Fruits As Natural Medicine...