Medical Advances

Science Advances in Medicine.
#MedEd #MedTwitter #Technology #Science #Research #News

[Medical Advances @MedicalAdv]

A comprehensive analysis of biological clocks across the human body reveals that both insufficient and excessive sleep are associated with accelerated aging in nearly every organ system.

[Science News @SciencNews]

Both short sleep (fewer than 6 hours) and long sleep (greater than 8 hours) correlate with faster biological aging. @Nature

[Nutrition Science @NutrioSci]

The Innovation Nutrition: An international journal of nutrition science

Open Access
https://t.co/oERdu3HnfN

[Nutrition Science @NutrioSci]

INAUGURATION  
The Innovation Nutrition: An international journal of nutrition science

Open Access
https://t.co/r0o0BB34ld

[Nutrition Science @NutrioSci]

Fasting-mimicking diet offers new ways for crohn’s diseases management

Open Access
https://t.co/TtW5xfaf2M

[Nutrition Science @NutrioSci]

Revisiting computational immunogenicity prediction for novel food ingredients

Open Access
https://t.co/gvMiJtIit0

[Nutrition Science @NutrioSci]

The challenge of weight management: Looking beyond short-term solutions

Open Access
https://t.co/PLw4C145jv

[Science News @SciencNews]

Time-restricted feeding extends healthspan in both sexes and lifespan in male @NatureAging

[Top Science @isciverse]

Why we need a good mood before bed

[Top Science @isciverse]

Guidelines for the diagnosis and management of childhood immunoglobulin A vasculitis

[Top Biomedical Science @imedverse]

Clinical practice guidelines for rituximab treatment in children with steroid-sensitive nephrotic syndrome

[Top Biomedical Science @imedverse]

Clinical practice guidelines for acute infectious diarrhea in children in China

[Top Science @isciverse]

Tumor Metabolism: The Central Integrating Node of the 2026 Cancer Hallmarks

Open Access
https://t.co/9S0puMINir

In January 2026, Douglas Hanahan updated the "Cancer Hallmarks" framework. Our recent commentary in The Innovation Nutrition argues that tumor metabolism is no longer just a classic hallmark, but the "universal language" linking all dimensions of cancer biology. 

By positioning metabolic reprogramming at the center, we bridge FOUR critical dimensions: 
1. Core Hallmarks: Metabolism fuels proliferation and facilitates immune evasion via lactate-mediated acidification. 
2. Enabling Characteristics: It acts as a master conductor of epigenetic changes and is the "behind-the-scenes driver" of phenotypic plasticity. 
3. Microenvironmental Cells: The TME functions as a metabolic ecosystem where cancer cells and stromal cells (like CAFs) engage in "metabolic collaboration". 
4. Systemic Interactions: We highlight the emerging roles of neural regulation, the gut microbiome, and systemic conditions like cachexia in tumor progression. 

This multidimensional perspective provides a theoretical foundation for "Hallmark-guided personalized therapy".

By co-targeting metabolic nodes alongside other hallmarks, we can overcome therapy resistance and move toward true precision oncology.

#Cancer #CancerResearch #metabolism #Hallmark #Science #ASCO26 #TumorEnvironment #metastasis #news #TME #oncology #CAFs

[Science News @SciencNews]

Male G-spot

[Top Science @isciverse]

G-spot found in penis

A long-overlooked area of the penis has been found to have the highest concentration of nerve endings and sensory structures in the organ, suggesting that it is the “male G-spot”

[Top Biomedical Science @imedverse]

Ageing promotes metastasis via activation of the integrated stress response. @nature #ASCO26

[Science News @SciencNews]

40% of European Gas Stoves Leak Benzene, Even When Turned Off

[Science News @SciencNews]

DZD6008: A Fourth-Generation EGFR TKI Overcomes Resistance Following Third-Generation EGFR TKI Failure. @ASCO #ASCO26

DZD6008 demonstrated strong and durable anti-tumor activity in patients relapsed from third-generation EGFR TKI with a favorable safety profile.

[Dizal Pharmaceutical @Dizal_Global]

Our #ASCO26 highlights: Oral data for DZD6008 demonstrating strong and durable anti-tumor activity and excellent BBB penetration following third-generation EGFR TKIs.
https://t.co/6MNLwgL614

#NSCLC #oncology #EGFR

[Top Biomedical Science @imedverse]

DZD6008, a fourth-generation EGFR TKI, showed encouraging activity in heavily pretreated EGFR C797X+ NSCLC.

• ORR 41.7% across dose levels
• Tumor shrinkage in 75% of patients
• ORR reached 60.0% at the 60 mg RP2D

#ASCO26 #NSCLC #EGFR #lcsm

[Top Biomedical Science @imedverse]

@OncoAlert ZEGFROVY® (sunvozertinib) monotherapy demonstrated superior anti-tumor efficacy, compared to platinum-doublet chemotherapy, in untreated NSCLC patients with EGFR exon 20 insertion mutations (exon20ins).