Mel Cook

[Anish Moonka @anishmoonka]

In 1935, two American doctors examined seven women's ovaries and saw small lumps. They called them cysts and named the disease after them. They were wrong. It took 91 years to fix.

What we called PCOS is now Polyendocrine Metabolic Ovarian Syndrome (PMOS), announced today in The Lancet by an international panel of doctors and patients. The renaming followed more than a decade of consensus work and 22,000 patient and clinician survey responses.

The lumps Stein and Leventhal saw were never cysts. Modern imaging shows they were follicles, the tiny sacs inside the ovary that grow and release an egg each month, frozen partway through by a hormonal imbalance. PMOS is a multi-system disorder centered in the endocrine system, the body's network of glands that produces hormones like insulin (controls blood sugar), cortisol (the stress hormone), and thyroid hormones (set the body's metabolism). The ovary trouble flows downstream from there.

The naming choice is not academic. When doctors hear "ovary" in a diagnosis, they look at the ovary. "Metabolic" and "endocrine" send them to the whole body.

PMOS affects roughly 1 in 8 women worldwide, more than 170 million people. The WHO estimates 70% have never been diagnosed. Among those who do, 1 in 3 wait more than 2 years, and nearly half see 3 or more doctors first. The CDC reports more than half of women with PMOS develop type 2 diabetes by age 40, a risk 5 to 10 times higher than women without the condition. Around 37% have clinically significant depression, compared with 14% in women without it. Anxiety runs at 42% versus 8.5%.

A label born from a 1935 look at seven ovaries is finally going away. The new diagnostic guidelines roll out fully in 2028. By then, a woman walking into a clinic with these symptoms should hear questions about her blood sugar and her mood alongside her cycle. Those are the parts of the disease the old name hid for 91 years.

[Mel Cook @MelCook17]

@ScotRail You can only purchase it as an additional ticket when paying for a full price adult!

[Mel Cook @MelCook17]

@ScotRail Can you please reconsider allowing ‘kids for a quid’ as an available online option?
This is the only time I purposely need to wait to purchase tickets on board, but this is not something clearly identified as an exclusion reason that I can see.

[Mel Cook @MelCook17]

@ReduxGB @ScotRail Great to know, but I would prefer all exclusions to be clearly documented before I risk boarding. Otherwise, I fear any debate over a fine/charge may be at a collector discretion 🤷‍♀️

[This Is My Glasgow @is_glasgow]

Spotted on Kew Terrace today, this has to be the most Glaswegian sign I've seen in a long time. If you woke up after a night out recently in bed with a hangover and more gnomes than usual, please return them to their rightful home.

#glasgow #keepglasgowweird #returnthegnomes

[Sesame Street @sesamestreet]

We like you just the way you are. 💚

[Susa 𓇢𓆸 @prinkasusa]

My coworker used to take the long way home every night. Two extra bus stops, more walking, more money, more time. One day I asked her why she didn’t just take the shortcut alley behind our building.
She laughed and said, “Oh, because a guy followed me there once and told me he could ‘do whatever he wanted’ and no one would hear me scream.”
So now, every night, she calls a male friend and pretends she’s on the phone with her “boyfriend.” Sometimes she even laughs loudly and says things like, “Yeah, I’ll see you in five minutes, babe,” even when she’s completely alone.
Not because she wants attention.
Not because she’s dramatic.
Because sounding “taken” and “protected” is safer than sounding like a woman by herself.
Men cannot even begin to understand the calculations women make every day just to get home alive.

[Sesame Street @sesamestreet]

Just a reminder that you are doing your best, and that’s more than enough. It’s okay to take it one day at a time.

[𝓑ᥫ᭡ @quesadaaa_]

I don’t want to be rich so I can buy a Rolex or a Chanel bag. I want to be rich so I can take my parents on holiday. So I can go to the gym randomly at 2 pm on a Wednesday. So I can cook every meal at home with fresh ingredients. So I can walk through nature in a place where I feel safe. So I can treat a friend to coffee without worrying if it tips me over budget. That’s the rich life I want to cultivate, not the one that was sold to me.

[blue @bluewmist]

i have no desire to be rich so i can buy a rolex or a lamborghini.

i want to be rich so i can control my time and go to the gym at 3pm on a monday.

sit at a cafe and relax for an hour on a rainy afternoon.

so i can cook meals at home with fresh ingredients.

spend on my family and friends without worrying about a budget.

that's my idea of a rich life, not the fake consumerist idea shoved down my throat.

[James Treadwell @James_Treadwell]

Please everyone help. I am trying to do a Christmas miracle and make someone happy. Yesterday (21/12/25) in @Bullring we found this lost platinum wedding band. It is name and date engraved, and has more detail. I want to reunite it with its rightful owner. Retweets might help.

[IRN-BRU @irnbru]

🎶 You think this tale is done
Not when you nick my IRN-BRUUUUUU 🎶
#Snowman #IRNBRU

[Mel Cook @MelCook17]

@NewMonklandG Aww well done NMPS

[Mel Cook @MelCook17]

@NewMonklandG Well done 🥰

[Chorley FC @chorleyfc]

We’ve had a number of questions over the last few weeks asking whether Chorley FC will be opening again on Christmas Day…

and after talking with the team at the @ChorleyFCCF, the answer became very clear.

Last year we heard from so many people who said that if we hadn’t opened our doors, they would have spent the day alone. That’s something we just couldn’t turn our backs on.

So yes, we’re opening again this Christmas Day, from noon until 4pm.

If you want somewhere to be, somewhere warm, friendly and full of a bit of Christmas spirit, you’ll be more than welcome at Victory Park. We’ll make sure you’ve got something to eat, a warm drink, and good company.

We’ve got you, Chorley. 🖤🤍

[Elena Song 🤯 @elenasongsong]

My mom goes to elderly university for free in China. It is probably the best thing they have done for elderly. She likes it so much. You can take any subject you like, no exam, no certificate, just learning for fun. She’s now learning gardening, music, philosophy, and some geopolitics. There are farmers travelling all the way to the school everyday to learn. This is 1000x better than stupid elderly home which basically kill elderly quickly rather than care.

[The Royal Family @RoyalFamily]

At the going down of the sun and in the morning, We will remember them.

[Sue Johnston @SJohnstonUK]

Let’s get this out there far & wide. We NEED #Brookside back on our screens. As its own show or bring the Brookie cast into #Hollyoaks. Retweet if you agree ❤️

[karen thompson @karenfthompson]

Twits of a certain age..

Who remembers the Sunday evening horror ...
hair wash night with one of these & a bottle of Vosene.
Once the rubber attachments had stopped flying off the taps,
your mum would alternatively inflict third degree burns and hypothermia, aiming the nozzle indiscriminately over the top of your head, washing copious amounts of shampoo into your eyes.
All whilst yelling at you to keep still …
Kids today don't know they're born 😂

[MR DT @MrDtAFC]

Gooners. I need your help. My brother travelled to Paris last night via a supporters coach for tonight's game.

About 10am, he was on the phone to his daughter as his wife was not answering the phone. She had to break the news to him that her Mum (his wife) had died some time this morning.

This is where I need your help. An Arsenal fan who was with their group heard what had happened. He got my brother on a Eurostar home and insisted on paying for it. Whilst my brother was grieving, someone was there to help him. I need to know who it was. I need to repay him, or at least thank him. As a family, we are grieving, but knowing someone has done this warms your heart.

If he wants to remain anonymous, that's fine. He didn't do it for publicity. We want to know who it was and thank him. You have no idea what you have done for my brother.

If anyone can help, please let me know