Ray Peat on the proper mindset:
"[The] excitedly expectant state of consciousness of a child on Christmas morning is a model of the way the mind should function throughout life."
#mindset
A few comments on this:
The second study I posted used enterically coated aspirin. That might be the reason for the damage.
The dosage of the first study was high around 3g (HED), so that could be a reason.
They do not specify if the aspirin was enterically coated, so I've contacted the study authors on that matter.
A reasonable alternative might be sodium salicylate, which has actually been shown to treat gut damage.
Aspirin causes intestinal damage?
Interesting study showing that short-term administration of aspirin causes intestinal damage through an alteration of bile acids and downregulation of the bile acid receptor FXR. Unfortunately, the effect doesn’t seem to dissipate over time like the stomach damage induced by aspirin; the intestinal damage was still present after 14 days of aspirin administration.
I’m not sure why that damage occurred, because it seems to have increased the more benign bile acids like TUDCA and downregulated the primary bile acids, as far as I can tell.
“In the aspirin-induced intestinal injury model, conjugated bile acids (T-β-MCA, TCA, TUDCA, TDCA, and TLCA) were significantly increased, while CA and CDCA were distinctly decreased.”
“…ASA decreased FXR expression in the ileum.”
PMID: 38542397
Now that I think about it, my cholestasis issues may have gotten worse around the time I started taking aspirin daily… weird.
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Here’s another study: 80% of the people in the aspirin group had intestinal damage, while only 20% in the control group did.
“After 2 weeks of treatment, the percentages of subjects with small bowel pathology were 80% in the Aspirin group compared with 20% in the Control group (p = 0.023).”
PMID: 19246922
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The question is: how significant is this damage?
I've attached two interesting editorials highlighting the intestinal damage. But it still doesn’t seem clear how pathological that damage really is.
The fact that people taking aspirin have a strongly reduced risk of getting colon cancer, makes this seem less concerning.
Aspirin causes intestinal damage?
Interesting study showing that short-term administration of aspirin causes intestinal damage through an alteration of bile acids and downregulation of the bile acid receptor FXR. Unfortunately, the effect doesn’t seem to dissipate over time like the stomach damage induced by aspirin; the intestinal damage was still present after 14 days of aspirin administration.
I’m not sure why that damage occurred, because it seems to have increased the more benign bile acids like TUDCA and downregulated the primary bile acids, as far as I can tell.
“In the aspirin-induced intestinal injury model, conjugated bile acids (T-β-MCA, TCA, TUDCA, TDCA, and TLCA) were significantly increased, while CA and CDCA were distinctly decreased.”
“…ASA decreased FXR expression in the ileum.”
PMID: 38542397
Now that I think about it, my cholestasis issues may have gotten worse around the time I started taking aspirin daily… weird.
_______
Here’s another study: 80% of the people in the aspirin group had intestinal damage, while only 20% in the control group did.
“After 2 weeks of treatment, the percentages of subjects with small bowel pathology were 80% in the Aspirin group compared with 20% in the Control group (p = 0.023).”
PMID: 19246922
______
The question is: how significant is this damage?
I've attached two interesting editorials highlighting the intestinal damage. But it still doesn’t seem clear how pathological that damage really is.
The fact that people taking aspirin have a strongly reduced risk of getting colon cancer, makes this seem less concerning.
@BasedInHealth I also stopped using it for now. I noticed that it seems to make me irritable after I take it (even with food etc.)
I think mineral-salicylate bonds could be better. Sodium salicylate, magnesium salicylate etc.
@DA_ResearchLabs I don't think the colon damage is related to prostaglandins, that's the stomach damage.
The colon damage seems to be related to an alteration of bile acids that are being produced.
Low PUFA and low iron can make you a lot less susceptible to sunburn. You don't need sunscreen.
So you can get all the benefits of sunlight while not aging your skin.
No free lunch, they say ...?
The more time you spend in the sun, the longer you live. ☀️
The sun is a good example of:"You can have your cake and eat it,too"
https://t.co/gfm36xlyaf
Use red light after sun exposure for maximal benefits.
"Around 1972, someone reported that sunlight shining on dark hair induces free radicals, and that these free radicals persist for hours in darkness. But exposure to red light 'quenches' the free radicals within seconds."
- Ray Peat
The same thing happens on the skin btw.
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Sources:
https://t.co/hCDJPPZiSL
https://t.co/qxKlvEt8Dt