Metabolic M

Everybody deserves good Health

[Metabolic M @Metabolicmonstr]

"To see a World in a Grain of Sand
And a Heaven in a Wild Flower
Hold Infinity in the palm of your hand
And Eternity in an hour..."
— William Blake

[Metabolic M @Metabolicmonstr]

Ray Peat on the proper mindset:

"[The] excitedly expectant state of consciousness of a child on Christmas morning is a model of the way the mind should function throughout life."

#mindset

[Metabolic M @Metabolicmonstr]

@lowmegatron Great find. Do you know how much protein they consumed?

[Metabolic M @Metabolicmonstr]

@JungianPeater The thing is that we don't know if the gut damage on 1g or 500mg was non existent.

[Metabolic M @Metabolicmonstr]

A few comments on this:

The second study I posted used enterically coated aspirin. That might be the reason for the damage.

The dosage of the first study was high around 3g (HED), so that could be a reason.
They do not specify if the aspirin was enterically coated, so I've contacted the study authors on that matter.

A reasonable alternative might be sodium salicylate, which has actually been shown to treat gut damage.

[Metabolic M @Metabolicmonstr]

Aspirin causes intestinal damage?

Interesting study showing that short-term administration of aspirin causes intestinal damage through an alteration of bile acids and downregulation of the bile acid receptor FXR. Unfortunately, the effect doesn’t seem to dissipate over time like the stomach damage induced by aspirin; the intestinal damage was still present after 14 days of aspirin administration.

I’m not sure why that damage occurred, because it seems to have increased the more benign bile acids like TUDCA and downregulated the primary bile acids, as far as I can tell.

“In the aspirin-induced intestinal injury model, conjugated bile acids (T-β-MCA, TCA, TUDCA, TDCA, and TLCA) were significantly increased, while CA and CDCA were distinctly decreased.”

“…ASA decreased FXR expression in the ileum.”
PMID: 38542397

Now that I think about it, my cholestasis issues may have gotten worse around the time I started taking aspirin daily… weird.

_______

Here’s another study: 80% of the people in the aspirin group had intestinal damage, while only 20% in the control group did.

“After 2 weeks of treatment, the percentages of subjects with small bowel pathology were 80% in the Aspirin group compared with 20% in the Control group (p = 0.023).”
PMID: 19246922
______

The question is: how significant is this damage?

I've attached two interesting editorials highlighting the intestinal damage. But it still doesn’t seem clear how pathological that damage really is.
The fact that people taking aspirin have a strongly reduced risk of getting colon cancer, makes this seem less concerning.

[Metabolic M @Metabolicmonstr]

@t0lstoiy What did you notice ?

[Metabolic M @Metabolicmonstr]

This is OG Ballmaxxing btw

[Metabolic M @Metabolicmonstr]

@bfoodavailable Not a single mention of lanolin on balls either 😞

[Metabolic M @Metabolicmonstr]

@JanDit7 I know I literally said this .

[Metabolic M @Metabolicmonstr]

Aspirin causes intestinal damage?

Interesting study showing that short-term administration of aspirin causes intestinal damage through an alteration of bile acids and downregulation of the bile acid receptor FXR. Unfortunately, the effect doesn’t seem to dissipate over time like the stomach damage induced by aspirin; the intestinal damage was still present after 14 days of aspirin administration.

I’m not sure why that damage occurred, because it seems to have increased the more benign bile acids like TUDCA and downregulated the primary bile acids, as far as I can tell.

“In the aspirin-induced intestinal injury model, conjugated bile acids (T-β-MCA, TCA, TUDCA, TDCA, and TLCA) were significantly increased, while CA and CDCA were distinctly decreased.”

“…ASA decreased FXR expression in the ileum.”
PMID: 38542397

Now that I think about it, my cholestasis issues may have gotten worse around the time I started taking aspirin daily… weird.

_______

Here’s another study: 80% of the people in the aspirin group had intestinal damage, while only 20% in the control group did.

“After 2 weeks of treatment, the percentages of subjects with small bowel pathology were 80% in the Aspirin group compared with 20% in the Control group (p = 0.023).”
PMID: 19246922
______

The question is: how significant is this damage?

I've attached two interesting editorials highlighting the intestinal damage. But it still doesn’t seem clear how pathological that damage really is.
The fact that people taking aspirin have a strongly reduced risk of getting colon cancer, makes this seem less concerning.

[Metabolic M @Metabolicmonstr]

@BasedInHealth I also stopped using it for now. I noticed that it seems to make me irritable after I take it (even with food etc.)

I think mineral-salicylate bonds could be better. Sodium salicylate, magnesium salicylate etc.

[Metabolic M @Metabolicmonstr]

@DA_ResearchLabs Oh sorry small bowel I mean.
But still seems to be related to bile acids.

[Metabolic M @Metabolicmonstr]

@DA_ResearchLabs I don't think the colon damage is related to prostaglandins, that's the stomach damage.

The colon damage seems to be related to an alteration of bile acids that are being produced.

[Metabolic M @Metabolicmonstr]

https://t.co/qfrXMGVjRS

[Metabolic M @Metabolicmonstr]

@mesutietoetie So true! A few years ago you could at least get frozen fries fried in Palm oil but now everything's sunflower oil ...

[Metabolic M @Metabolicmonstr]

@GannonGains Is the metabolic increase medicated by stress hormones ?

[Metabolic M @Metabolicmonstr]

@MyProtocols The reduction in DHT is wild. It was in female rats btw.

[Metabolic M @Metabolicmonstr]

@metabolicwave It sounds fake but it isn't.

https://t.co/gSAEIOHoLk

[El @el7_77]

One source: https://t.co/NiupDFYk9c

[Metabolic M @Metabolicmonstr]

Yesterday I met a friend and she put on two different types of sunscreen at 7PM in the evening. 👽

[Metabolic M @Metabolicmonstr]

Iron causes skin aging and sun burn.

PMID: 10359784; 41537057

[Metabolic M @Metabolicmonstr]

Low PUFA and low iron can make you a lot less susceptible to sunburn. You don't need sunscreen.
So you can get all the benefits of sunlight while not aging your skin.
No free lunch, they say ...?

[Metabolic M @Metabolicmonstr]

Spending time in the sun is correlated with lower all cause mortality
https://t.co/Ajznw0tbBE

[Metabolic M @Metabolicmonstr]

The more time you spend in the sun, the longer you live. ☀️

The sun is a good example of:"You can have your cake and eat it,too"
https://t.co/gfm36xlyaf

[Metabolic M @Metabolicmonstr]

Red light after sun exposure
https://t.co/pgr21Nkibp

[Metabolic M @Metabolicmonstr]

Use red light after sun exposure for maximal benefits.

"Around 1972, someone reported that sunlight shining on dark hair induces free radicals, and that these free radicals persist for hours in darkness. But exposure to red light 'quenches' the free radicals within seconds."
- Ray Peat

The same thing happens on the skin btw.
___

Sources:
https://t.co/hCDJPPZiSL

https://t.co/qxKlvEt8Dt