🚨Just published in Clinical Epigenetics!
1 in 3 women ≤30 with triple-negative breast cancer (TNBC) carry a hidden BRCA1 epimutation — missed by genetic tests.
🧬 Detected with MethylDetect™ MS-HRM.
👉 https://t.co/l1Mpys3cBA
#BRCA1#Epigenetics#TNBC#MethylDetect
Constitutional BRCA1 Epimutations: A Key for Understanding Basal‐Like Breast and High‐Grade Serous Ovarian Cancer - Lønning - 2024 - Human Mutation - Wiley Online Library https://t.co/YvygdvIYqQ
#brca1#methylation detectable in blood is a potential breast and ovarian cancer risk factor, see also: #EpiMelthBRCA1 kit https://t.co/SerJsaXmrp
https://t.co/qwkcEfEfdY
Silencing of the MGMT gene by promoter methylation results in decreased MGMT protein expression and thereby reduced DNA repair activity. This will potentially increase the sensitivity of the tumor cell to chemotherapy.
Just published a method for automated analysis of #methylation#epigenetics data #PCR#diagnostics
Methylation levels assessment with Methylation-Sensitive High-Resolution Melting (MS-HRM) https://t.co/LyM5ps4llA