Michal Paluba

Physiology | Neuroscience | PhD candidate @CharlesUniPRG | @science_charles | @NovotnyLab

[Novotny Lab @NovotnyLab]

Great success of Alp Yigit Özdemir from
@NovotnyLab with his article in Cellular & Molecular Biology Letters of @BioMedCentral with JIF: 9.2 ! Congratulations 👏👏👏 #Neuroscience @science_charles @CharlesUniPRG ➡️https://t.co/towTTZWdJH

[ジェシカ Jessica Gerrity @jessintokyo]

Happy Friday everyone!
皆さん素敵な金曜日を🫶
Have a wonderful day❤️
📍飛鳥山公園
📸 Hiro
#秩父銘仙 #着物 #kimono
#武士の作法 #IndependenceDay #4thofJuly #photography #Japan #アンティーク

[Novotny Lab @NovotnyLab]

Great success of Pinky Sultana and her co-investigators @MichalPaluba and Alp Yigit Özdemir from @NovotnyLab for receving a GAUK grant for their project: "Investigation of oxidative stress- or amyloid-β-induced senescence in a 3D astrocyte model" 👏 #GAUK #neuroscience #astrocyte

[ジェシカ Jessica Gerrity @jessintokyo]

おはようございます✨
Happy Saturday
秩父銘仙着物 x 紫陽花 x 和傘
先日撮影からの一枚
I love hydrangeas💜
飛鳥山公園の紫陽花が美しかった💜
素敵な週末を🫶
#kimono #銘仙 #photography #canon
#アンティーク着物 #伝統工芸品 #伝統工芸 #伝統文化 #TGIF #FlowerFriday

[Novotny Lab @NovotnyLab]

Role of TRH receptor activation in gene transcription, identifying key phosphosignaling pathways in GH1 cells, highlighting β-arrestin2's crucial role in TRH-R signal transduction by @ZDrastichova from @NovotnyLab.
➡️https://t.co/dUlV6fiZqy
#neuroscience #TRHreceptor #taltirelin

[Novotny Lab @NovotnyLab]

Congratulations to @EliskaPritulova for receiving GAUK grant with her project "Study of epigenetic regulation in the rat brain affected by chronic methadone administration and withdrawal" and also to her co-investigators @DanielaNov75805, @hronova20441 from @NovotnyLab. 👍 #GAUK

[Novotny Lab @NovotnyLab]

Amyloid β, linked to Alzheimer's disease, is influenced by cholesterol levels, which affect its production and the activity of related proteins. By Vladimir Rudajev from @NovotnyLab | #amyloidbeta #alzheimer #neuroscience | @science_charles @UniKarlova
https://t.co/qE9kCL0Xdh

[Novotny Lab @NovotnyLab]

Great achievement of @withdebanjan from @NovotnyLab in GAUK with his project: "BTK inhibitor ibrutinib in the treatment of neuroinflammation and neurodegeneration".
Congratulations! 👏👏👏
#neuroscience #microglia #ibrutinib #btkinhibitor #glia

[Novotny Lab @NovotnyLab]

Interesting article about Role of Capsaicin in Inflammation from Vendula Nagy Marková,@OndrejHonc and Barbora Melkes from @NovotnyLab, with cooperation with @Krulova_Lab. #novotnylab #immunology #inflammation #TRPV1 #macrophage #J774 #BMDMS | @science_charles

[Novotny Lab @NovotnyLab]

Our talented student @withdebanjan from @NovotnyLab and @TheParcPrague represented us at the conference - Květinův Den held in Prague, Czech Republic. This motivational event, aimed at young pharmacologists and toxicologists, offered a fantastic platform for exchanging knowledge.

[Novotny Lab @NovotnyLab]

Methadone enhances temozolomide's effectiveness against glioblastoma cells independently of opioid receptors, by affecting mitochondrial potential, oxidative stress, intracellular Ca2+, ATP levels, DNA integrity, and PARP-1 activity
@OndrejHonc #novotnylab
https://t.co/8Zcz18mHpY

[Novotny Lab @NovotnyLab]

Great review about Rab11 and Its Role in Neurodegenerative Diseases from our PhD candidate Pinky Sultana.
Published in @ASNeurochem.
➡️https://t.co/BYURET9KzR

[Novotny Lab @NovotnyLab]

We found the changes in redox state and protein expression in selected parts of the rat brain induced by a 4 week administration of morphine. Published in Open Life Sciences by @degruyter_brill. #neuroscience #morphine #novotnylab
➡️https://t.co/Rqnwgjcd6w

[Novotny Lab @NovotnyLab]

Opioid receptor agonists (DAMGO, DADLE, U-50488) exhibit antioxidant and anti-inflammatory effects in LPS-activated microglial cells, enhancing mitochondrial function and reducing ROS via the Nrf2/HO-1 pathway. By @akashmit97👍 #neuroscience #novotnylab
➡️https://t.co/YnwgleLqtk

[Novotny Lab @NovotnyLab]

Our research focuses on the molecular mechanisms of receptor signaling, particularly trimeric G protein-coupled receptors. We investigate their roles in various physiological contexts, using diverse methods to understand and potentially address related pathological conditions.