ADMIRE CD II, a global phase 3 randomized trial, found no significant difference between darvadstrocel and placebo for combined remission in patients with #CrohnsDisease and complex perianal fistulas. Furthermore, no new safety signals were identified.
🔗 https://t.co/63Fl6wfIbe
💧 Cirrhosis + ascites + normal Na?
👉 No free water restriction — only salt restriction is needed.
Fluid restriction only if Na <125 mmol/L.
Otherwise, it worsens nutrition & QoL.
(AASLD 2021, EASL 2018)
#Cirrhosis#MedTwitter
Upper GI involvement in Crohn’s disease🧵
1. Upper GI involvement in CD: 3–16%.
2. Adults: Routine UGIE is not recommended, except when upper GI symptoms are present.
3. Children <17 years: Routine UGIE is recommended at diagnosis to screen for upper GI involvement.
#IBD#CD
8/ Clinical Pearl 💡
Always combine LS with clinical (CDAI/HBI), biomarkers (CRP, fecal calprotectin), and imaging (MRE/CTE) before treatment changes.
Have you ever used LS?
Lewis Score in Crohn’s disease (CD) with Capsule Endoscopy 🧵
Capsule endoscopy allows direct visualization of small bowel mucosa in IBD.
But how do we quantify inflammation? 🔍
➡️ Lewis Score (LS) is the most widely used index.
#MedTwitter#Gastrotwitter#GastroX#IBD
Takeaway 📝
Vienna: first, simple
Montreal: Adult, standard
Paris: pediatric, most detailed
BSG IBD guidelines 2025 recommends using Montreal for adults and Paris for children.