Midwest Startups

Navigating the ever-growing Midwest startup ecosystem. Visit our site for job listings, startup + VC news, newsletter and our talent network. Powered by @M25vc.

[Midwest Startups @MidwestStartups]

🚨 The #BestofMidwest2025 Startup City Rankings are here!

We analyzed 25 weighted variables across 50+ cities to see which ecosystems are thriving—and which have some work to do. 🧵

[Midwest Startups @MidwestStartups]

Chicago-based @SNAKVC announced a $50M FI.

They will back early-stage vertical B2B marketplaces digitizing industries like construction, logistics and industrial—sectors still operating on analog workflows that are ready for technology-driven platforms.
https://t.co/l1gFhR22ul

[Midwest Startups @MidwestStartups]

📣 Entravia
📍 Minneapolis, MN
🗂️ HR / PEO
💰 Pre-seed round led by @M25vc with participation from Cambrian
https://t.co/znko2O6LFp

[Midwest Startups @MidwestStartups]

Chicago-based Ariel Project Level announced a $250M fund.

Launched by Ariel Investments, the fund aims to capitalize on the continued growth of women’s sports across fandom, viewership and media coverage.
https://t.co/DyCYdW8ezQ

[Midwest Startups @MidwestStartups]

What's new on the #MidwestStartups job board?

✉️ Customer Enablement Specialist - @useworkshop
🏡 Senior Loan Officer - @KIN
🚗 Marketing Operations Analyst - @SuperDispatch

Find more of the latest opportunities here:
https://t.co/31kPGmiZhq

[Midwest Startups @MidwestStartups]

📣 @WhenInsurance
📍 Chicago, IL
🛡️ Insurtech
💰 $10.2M Series A co-led by @ManchStoryGrp and @7wireventures
https://t.co/kiAtK3Ny7D

[Midwest Startups @MidwestStartups]

📣 @opendate_app
📍 Indianapolis, IN
📆 Event Management
💰 $14M Series A led by @highalpha .
https://t.co/K74VANwmLl

[Midwest Startups @MidwestStartups]

Chicago-based @treatmyocd has acquired Rebound Health for an undisclosed amount:
https://t.co/cfiq46h460

[Midwest Startups @MidwestStartups]

Columbia, MO-based @EquipmentShare has IPO'd.

Their Class A common stock has begun trading on the Nasdaq Global Select Market under the ticker symbol “EQPT.”
https://t.co/BrGvM5n7K6

[Midwest Startups @MidwestStartups]

📣 Zarminali Pediatrics
📍 Chicago, IL
🩺 HealthTech
💰 $110M Series A led by Healthier Capital
https://t.co/SQDGWNaReL

[Midwest Startups @MidwestStartups]

📣 Trailhead Biosystems
📍 Cleveland, OH
🔬 BioTech
💰 $20M in additional funding led by MAK Capital
https://t.co/yUeInYux8p

[Midwest Startups @MidwestStartups]

Chicago-based @obieinsurance has been acquired by The Baldwin Group for an undisclosed amount:
https://t.co/LRlAljH7GP

[Midwest Startups @MidwestStartups]

It's newsletter week! 📰

Looking for funding announcements, upcoming tech events and a few of the latest job opportunities from across the Midwest? Join the #MidwestStartups mailing list!

Get subscribed: https://t.co/SKG6Y4WaTt

[Midwest Startups @MidwestStartups]

What's new on the #MidwestStartups job board this week?
https://t.co/31kPGmiZhq

✉️ Director of Marketing - @useworkshop
🧑‍⚕️ Director, Account Management - @steadymd
🏡 Staff Software Engineer - @KIN

[Midwest Startups @MidwestStartups]

📣 Onsetto
📍 Minneapolis, MN
📈 FinTech
💰 $2.2M Seed led by EJF Capital
https://t.co/HWWMdTW52A

[Midwest Startups @MidwestStartups]

📣 @BioReact_US
📍 Indianapolis, IN
🔬 BioTech
💰 $1.07M Pre-Seed led by @NewStackVC
https://t.co/ByhVJdih4H

[Midwest Startups @MidwestStartups]

📣 @CHAMPtitles
📍 Cleveland, OH
⚙️ Software / Transportation
💰 $55M round led by @WRBerkleyCorp, @p72vc and ORIX Corporation USA
https://t.co/RlDLkAtY6I

[Midwest Startups @MidwestStartups]

If one of your resolutions is staying plugged into the Midwest startup scene, we’ve got you covered. Funding, VC updates, jobs and events every other Thursday.
https://t.co/SKG6Y4WaTt

[Midwest Startups @MidwestStartups]

Looking for a new role in 2026? Join the #MidwestStartups talent network and find roles from 90+ Midwest-based companies.
https://t.co/lLNJnZIruw

[Midwest Startups @MidwestStartups]

A few of the latest roles from the #MidwestStartups job board:
https://t.co/31kPGmiZhq

✉️ Accounting Manager - @useworkshop
📊 AI Audit Specialist - Stealth
👐 Recruiter - @Carefeed_

[Midwest Startups @MidwestStartups]

📣 Alphyn Biologics, Inc.
📍 Cincinnati, OH + Annapolis, MD
🔬 Life Sciences
💰 $25M Series B led by @QueenCityAngels
https://t.co/zAjquzciko